An approximate line attractor in the hypothalamus encodes an aggressive state

Cell, Год журнала: 2023, Номер 186(1), С. 178 - 193.e15

Опубликована: Янв. 1, 2023

The hypothalamus regulates innate social behaviors, including mating and aggression. These behaviors can be evoked by optogenetic stimulation of specific neuronal subpopulations within MPOA VMHvl, respectively. Here, we perform dynamical systems modeling population activity in these nuclei during behaviors. In unsupervised analysis identified a dominant dimension neural with large time constant (>50 s), generating an approximate line attractor state space. Progression the trajectory along this was correlated escalation agonistic behavior, suggesting that it may encode scalable aggressiveness. Consistent this, individual differences magnitude integration were strongly contrast, attractors not observed mating; instead, neurons fast dynamics tuned to actions. Thus, different hypothalamic employ distinct codes represent similar

Язык: Английский

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Drawing as a versatile cognitive tool

Nature Reviews Psychology, Год журнала: 2023, Номер 2(9), С. 556 - 568

Опубликована: Июль 17, 2023

Язык: Английский

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Characterizing the structure of mouse behavior using Motion Sequencing

Nature Protocols, Год журнала: 2024, Номер 19(11), С. 3242 - 3291

Опубликована: Июнь 26, 2024

Язык: Английский

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Emotions and individual differences shape foraging under threat

Опубликована: Май 4, 2023

A common behaviour in natural environments is foraging for rewards. However, this often the presence of predators. Therefore, one most fundamental decisions humans, as other animals, how to apportion time between reward-motivated pursuit and threat-motivated checking behaviour. To understand what affects people strike balance, we developed a novel ecologically inspired task looked at both within-participant dynamics (moods) between-participant individual differences (questionnaires about real-life behaviours) two large internet samples (n=374 n=702) cross-sectional design. For dynamics, found that regulate task-evoked stress homeostatically by changing (increasing hiding). Individual differences, even superficially related traits (apathy-anhedonia anxiety-compulsive checking) reliably mapped onto unique behaviours. Worse performance, due maladaptive checking, was linked gender (women checked excessively) specific anxiety-related traits: somatic anxiety (reduced self-reported worry) compulsivity (self-reported disorganized checking). While anhedonia decreased engagement, apathy, strikingly, improved overall performance reducing excessive checking. In summary, provide multifaceted paradigm assessment threat naturalistic which sensitive moods they change throughout clinical dimensions. Thus, it could serve an objective measurement tool future studies interested threat, vigilance or behaviour-emotion interactions contexts requiring reward-seeking threat-avoidance.

Язык: Английский

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A neuronal substrate for translating nutrient state and resource density estimations into foraging decisions

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 19, 2023

Foraging animals must balance the costs of exploring their surroundings with potential benefits finding nutritional resources. Each time an animal encounters a food source it decide whether to initiate feeding or continue searching for potentially better options. Experimental evidence and patch foraging models predict that this decision depends on both state density available resources in environment. How brain integrates such internal external states adapt so-called exploration-exploitation trade-off remains poorly understood. We use video-based tracking show Drosophila regulates engage patches based travel between patches, latter being measure To uncover neuronal basis process, we performed neurogenetic silencing screen more than 400 genetic driver lines sparse expression patterns fly brain. identified population neurons central complex acts as key regulator patch. manipulating activity these alters probability engage, is modulated by protein animal, perturbs ability adjust decisions fly’s patches. Taken together, our results reveal substrate information control specific decision, therefore provide important step towards mechanistic explanation cognitive computations resolve cost-benefit trade-offs.

Язык: Английский

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Leveraging big data to uncover the eco-evolutionary factors shaping behavioural development

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2023, Номер 290(1992)

Опубликована: Фев. 1, 2023

Mapping the eco-evolutionary factors shaping development of animals’ behavioural phenotypes remains a great challenge. Recent advances in ‘big data’ research—the high-resolution tracking individuals and harnessing that data with powerful analytical tools—have vastly improved our ability to measure model developing phenotypes. Applied study ontogeny, unfolding whole repertoires can be mapped unprecedented detail relative ease. This overcomes long-standing experimental bottlenecks heralds surge studies more finely define explore behavioural–experiential trajectories across development. In this review, we first provide brief guide state-of-the-art approaches allow collection analysis We then outline how such used address key issues regarding ecological evolutionary development: developmental feedbacks between behaviour underlying states, early life effects transitions, information integration

Язык: Английский

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Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors

Cell Reports, Год журнала: 2025, Номер 44(2), С. 115239 - 115239

Опубликована: Фев. 1, 2025

Язык: Английский

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Emotions and individual differences shape human foraging under threat

Nature Mental Health, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Abstract A common behavior in natural environments is foraging for rewards. However, this often the presence of predators. Therefore, one most fundamental decisions humans, as other animals, how to apportion time between reward-motivated pursuit and threat-motivated checking behavior. To understand what affects people strike balance, we developed an ecologically inspired task looked at both within-participant dynamics (moods) between-participant individual differences (questionnaires about real-life behaviors) two large internet samples ( n = 374 702) a cross-sectional design. For dynamics, found that regulate task-evoked stress homeostatically by changing (increasing hiding). Individual differences, even superficially related traits (apathy–anhedonia anxiety–compulsive checking) reliably mapped onto unique behaviors. Worse performance, due maladaptive checking, was linked gender (women checked excessively) specific anxiety-related traits: somatic anxiety (reduced self-reported worry) compulsivity (self-reported disorganized checking). While anhedonia decreased engagement, apathy, strikingly, improved overall performance reducing excessive checking. In summary, provide multifaceted paradigm assessment threat naturalistic sensitive moods they change throughout clinical dimensions. Thus, it could serve objective measurement tool future studies interested threat, vigilance or behavior–emotion interactions contexts requiring reward seeking avoidance.

Язык: Английский

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Pile driving sound induces short-term behavioral changes in black sea bass (Centropristis striata): A field study

The Journal of the Acoustical Society of America, Год журнала: 2025, Номер 157(4), С. 2350 - 2364

Опубликована: Апрель 1, 2025

Offshore wind represents a renewable energy alternative as countries seek to limit the climate-altering effects of fossil fuels. The global investment in has generated substantial concern, turbine construction emits high-intensity sounds and associated impacts on marine fauna remain largely unknown. This situ experimental study quantified behavioral changes commercially important black sea bass (Centropristis striata) nearshore pile driving using video observation. Behavior caged was characterized at near far sites before during repeated bouts two contrasting techniques: impact vibratory hammering (VH), over consecutive days. At hammer onset, animals both reduced swimming midwater, switching bottom-associated freezing behaviors consistent with heightened alertness. Yet they returned pre-exposure states VH later sequences, even close highest peak-to-peak sound pressure levels (203-213 dB re 1μPa). Behavioral were more persistent site, but neither distance elicited significant second day exposure. results indicate that behavior may be initially altered by sound, these are short-lived do not continue through multiple exposures or

Язык: Английский

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Seminatural environments for rodent behavioral testing: a representative design improving animal welfare and enhancing replicability

Frontiers in Behavioral Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Июнь 22, 2023

The low replicability of scientific studies has become an important issue. One possible cause is representativeness the experimental design employed. Already in 1950’s, Egon Brunswick pointed out that setups ideally should be based on a random sample stimuli from subjects’ natural environment or at least include basic features environment. Only designs satisfying this criterion, representative Brunswikian terminology, can produce results generalizable beyond procedure used and to situations outside laboratory. Such external validity crucial preclinical drug studies, for example, general. Popular rodent research non-human animals, like tail suspension test Geller-Seifter procedure, do not correspond contexts likely encountered animals’ habitat. Consequently, obtained kind procedures generalized neither other nor Furthermore, many traditional are incompatible with current notions animal welfare. An approximation social physical context provided laboratory, form seminatural In addition satisfy demands design, such environments offer far higher level welfare than typical small cages. This perspective article will briefly discuss principles generalizability results, virtues coincidence enhanced quality by design.

Язык: Английский

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