The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Март 4, 2024

Neurodegenerative diseases refer to a battery of medical conditions that affect the survival and function neurons in brain, which are mainly presented with progressive loss cognitive and/or motor function. Acupuncture showed benign effects improving neurological deficits, especially on movement impairment. Here, we reviewed therapeutic mechanisms acupuncture at neural circuit level cognition disorders, summarizing influence dopaminergic system, glutamatergic γ-amino butyric acid-ergic (GABAergic) serotonergic cholinergic glial cells synaptic levels. These findings can provide targets for clinical treatment perspectives further studies.

Язык: Английский

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Adenosine signaling in glia modulates metabolic state-dependent behavior inDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 8, 2024

Summary An animal’s metabolic state strongly influences its behavior. Hungry animals prioritize food seeking and feeding behaviors, while sated suppress these behaviors to engage in other activities. Additionally, neuronal activity synaptic transmission are among the most energy expensive processes. Yet neurons do not uptake nutrients from circulation. Instead, glia fulfill this highly evolutionary conserved function. Recent studies have shown that can modulate However, how different subtypes sense behavior is incompletely understood. Here, we unravel two types of glia-mediated modulation state-dependent In food-deprived flies, astrocyte-like perineurial promote foraging feeding, respectively, cortex behaviors. We further show adenosine receptor intracellular calcium levels subtypes, which ultimately controls This study reveals a new mechanism animal accordingly.

Язык: Английский

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Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses

Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown

Опубликована: Дек. 6, 2024

Язык: Английский

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Role of trigeminal ganglion satellite glial cells in masseter muscle pain hypersensitivity

Journal of Oral Biosciences, Год журнала: 2024, Номер unknown, С. 100596 - 100596

Опубликована: Дек. 1, 2024

Язык: Английский

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