bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Март 26, 2024
Neural circuits are characterized by genetically and functionally diverse cell types. A mechanistic understanding of circuit function is predicated on linking the genetic physiological properties individual neurons. However, it remains highly challenging to map transcriptional heterogeneous neuronal subtypes in mammalian cortical
Язык: Английский
Cell Reports, Год журнала: 2024, Номер 43(4), С. 114115 - 114115
Опубликована: Апрель 1, 2024
In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, specific behavioral conditions that lead to disinhibition remain uncertain. To investigate relevance of VIP-IN activity, we employed wireless technologies allowing us monitor and manipulate their function freely behaving mice. Our findings reveal that, during spatial exploration new environments, VIP-INs hippocampal region become highly active, facilitating rapid encoding novel information. Remarkably, both pyramidal neurons (PNs) exhibit increased activity when encountering changes environment, including context- object-related alterations. Concurrently, somatostatin- parvalbumin-expressing inhibitory populations show an inverse relationship with PN revealing occurs on timescale seconds. Thus, VIP-IN-mediated may constitute crucial element novelty acquisition recognition memory.
Язык: Английский
Процитировано
13
Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(6), С. 428 - 448
Опубликована: Май 7, 2024
Язык: Английский
Процитировано
12
Fundamental and Clinical Pharmacology, Год журнала: 2023, Номер 38(2), С. 225 - 237
Опубликована: Сен. 27, 2023
Abstract Background Despite several hundred clinical trials of drugs that initially showed promise, there has been limited improvement in Alzheimer's disease (AD). This may be attributed to the existence at least 25 abnormal cellular pathways underlie disease. It is improbable for a single drug address all or most these pathways, thus even show promise when administered alone are unlikely produce significant results. According previous studies, eight drugs, namely, dantrolene, erythropoietin, lithium, memantine, minocycline, piracetam, riluzole, and silymarin, have found target multiple involved development AD. Among riluzole currently indicated treatment medical conditions both adult patients children gained increased attention from scientists due its potential excitotoxic hypothesis neurodegenerative diseases. Objective The aim this study was investigate effects on AD based molecular mechanisms. Methods literature search utilized Scopus, ScienceDirect, PubMed, Google Scholar databases identify relevant articles. Results Riluzole exerts through diverse including inhibition voltage‐dependent sodium calcium channels, blocking AMPA NMDA receptors inhibiting release glutamic acid stimulation EAAT1‐EAAT2. Conclusion In review article, we aimed neuroprotective properties glutamate modulator, AD, which could benefit with
Язык: Английский
Процитировано
13
Current Opinion in Neurobiology, Год журнала: 2023, Номер 81, С. 102734 - 102734
Опубликована: Июнь 4, 2023
Язык: Английский
Процитировано
12
Journal of Neuroscience, Год журнала: 2023, Номер 43(45), С. 7463 - 7471
Опубликована: Ноя. 8, 2023
Astrocytes are emerging as key regulators of cognitive function and behavior. This review highlights some the latest advances in understanding astrocyte roles different behavioral domains across lifespan disease. We address specific molecular circuit mechanisms by which astrocytes modulate behavior, discuss their functional diversity versatility, highlight astrocyte-targeted treatment strategies that might alleviate dysfunction pathologic conditions. Converging evidence model systems manipulations is revealing regulate processes a precise context-dependent manner. Improved these astrocytic functions may generate new therapeutic for various conditions with impairments.
Язык: Английский
Процитировано
12
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Дек. 22, 2023
Spatial memory in the hippocampus involves dynamic neural patterns that change over days, termed representational drift. While drift may aid updating, excessive could impede retrieval. Memory retrieval is influenced by reward expectation during encoding, so we hypothesized diminished would exacerbate We found high limited drift, with CA1 representations on one day gradually re-emerging successive trials following day. Conversely, absence of resulted increased as gradual re-emergence previous day's representation did not occur. At single cell level, lowering caused an immediate increase proportion place-fields low trial-to-trial reliability. These place fields were less likely to be reinstated day, underlying this condition. In conclusion, heightened improves encoding and maintaining reliable are across thereby minimizing
Язык: Английский
Процитировано
10
Chinese Journal of Physics, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(4), С. 532 - 532
Опубликована: Апрель 4, 2025
Background: Terahertz (THz) waves, lying between millimeter waves and infrared light, may interact with biomolecules due to their unique energy characteristics. However, whether THz are neurally regulated remains controversial, the underlying mechanism is elusive. Methods: Mouse brain slices were exposed 1.94 for 1 h. Synaptic plasticity was evaluated via transmission electron microscopy (TEM), long-term potentiation (LTP), neuronal class III β-tubulin (Tuj1) synaptophysin (SYN) expression. Immunofluorescence (IF) electrophysiology used identify neurons sensitive waves. The calcium activity of excitatory neurons, glutamate receptor currents, neuron marker expression also assessed using imaging, a patch clamp, Western blotting (WB). Optogenetics chemogenetics determine role in synaptic impairment after wave exposure. NMDA 2B (GluN2B) overexpressed ventral hippocampal CA1 (vCA1) by lentivirus clarify GluN2B wave-induced impairment. Results: Exposure increased postsynaptic density (PSD) thickness reduced field potential (fEPSP) slope Tuj1 SYN diminished vCA1 glutamatergic excitability, neural electrical activity, transporter function. N-methyl-D-aspartate (NMDAR) current amplitudes NMDAR subunit Activating through optogenetics mitigated overexpression improved expression, ultrastructure, fEPSP slope. Conclusions: decreased plasticity, vCA1. Glutamatergic activation alleviated impairment; thus, neuromodulation could be promising therapeutic strategy mitigate adverse effects radiation.
Язык: Английский
Процитировано
0
Journal of Affective Disorders, Год журнала: 2025, Номер 384, С. 12 - 22
Опубликована: Май 6, 2025
Язык: Английский
Процитировано
0
Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)
Опубликована: Июль 24, 2024
Abstract Background Depressive symptoms often occur in patients with Alzheimer's disease (AD) and exacerbate the pathogenesis of AD. However, neural circuit mechanisms underlying AD-associated depression remain unclear. The serotonergic system plays crucial roles both AD depression. Methods We used a combination vivo trans-synaptic circuit-dissecting anatomical approaches, chemogenetic manipulations, optogenetic pharmacological methods, behavioral testing, electrophysiological recording to investigate dorsal raphe nucleus mouse model. Results found that activity serotonin neurons (DRN 5-HT ) their projections hippocampal CA1 (dCA1) terminals -dCA1 CaMKII decreased brains early 5×FAD mice. Chemogenetic or activation DRN attenuated depressive cognitive impairments mice through receptor 1B (5-HT R) 4 R). Pharmacological R by regulating improve synaptic plasticity. Conclusions These findings provide new mechanistic connection between potential pharmaceutical prevention targets for
Язык: Английский
Процитировано
3