Ameliorative effect and underlying mechanism of the Xiaxue Kaiqiao formula on age-related dementia in Samp8 mice DOI
Lu Dai, Xiao‐Xu Wang, Meng Li

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 155801 - 155801

Опубликована: Июнь 12, 2024

Язык: Английский

Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory DOI Creative Commons
Suhel Tamboli, Sanjay Singh,

Dimitry Topolnik

и другие.

Cell Reports, Год журнала: 2024, Номер 43(4), С. 114115 - 114115

Опубликована: Апрель 1, 2024

In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, specific behavioral conditions that lead to disinhibition remain uncertain. To investigate relevance of VIP-IN activity, we employed wireless technologies allowing us monitor and manipulate their function freely behaving mice. Our findings reveal that, during spatial exploration new environments, VIP-INs hippocampal region become highly active, facilitating rapid encoding novel information. Remarkably, both pyramidal neurons (PNs) exhibit increased activity when encountering changes environment, including context- object-related alterations. Concurrently, somatostatin- parvalbumin-expressing inhibitory populations show an inverse relationship with PN revealing occurs on timescale seconds. Thus, VIP-IN-mediated may constitute crucial element novelty acquisition recognition memory.

Язык: Английский

Процитировано

13

Remapping revisited: how the hippocampus represents different spaces DOI
André A. Fenton

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(6), С. 428 - 448

Опубликована: Май 7, 2024

Язык: Английский

Процитировано

11

Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review DOI Open Access
Maryam Golmohammadi,

Mohammadreza Mahmoudian,

Ekhlas Khammas Hasan

и другие.

Fundamental and Clinical Pharmacology, Год журнала: 2023, Номер 38(2), С. 225 - 237

Опубликована: Сен. 27, 2023

Abstract Background Despite several hundred clinical trials of drugs that initially showed promise, there has been limited improvement in Alzheimer's disease (AD). This may be attributed to the existence at least 25 abnormal cellular pathways underlie disease. It is improbable for a single drug address all or most these pathways, thus even show promise when administered alone are unlikely produce significant results. According previous studies, eight drugs, namely, dantrolene, erythropoietin, lithium, memantine, minocycline, piracetam, riluzole, and silymarin, have found target multiple involved development AD. Among riluzole currently indicated treatment medical conditions both adult patients children gained increased attention from scientists due its potential excitotoxic hypothesis neurodegenerative diseases. Objective The aim this study was investigate effects on AD based molecular mechanisms. Methods literature search utilized Scopus, ScienceDirect, PubMed, Google Scholar databases identify relevant articles. Results Riluzole exerts through diverse including inhibition voltage‐dependent sodium calcium channels, blocking AMPA NMDA receptors inhibiting release glutamic acid stimulation EAAT1‐EAAT2. Conclusion In review article, we aimed neuroprotective properties glutamate modulator, AD, which could benefit with

Язык: Английский

Процитировано

13

Editorial overview: Neurobiology of learning and plasticity DOI
Thomas J. McHugh,

Mu‐ming Poo

Current Opinion in Neurobiology, Год журнала: 2023, Номер 81, С. 102734 - 102734

Опубликована: Июнь 4, 2023

Язык: Английский

Процитировано

12

Astrocytes as Drivers and Disruptors of Behavior: New Advances in Basic Mechanisms and Therapeutic Targeting DOI Creative Commons
Daniel Barnett, Kirsten Bohmbach,

Valentin Grelot

и другие.

Journal of Neuroscience, Год журнала: 2023, Номер 43(45), С. 7463 - 7471

Опубликована: Ноя. 8, 2023

Astrocytes are emerging as key regulators of cognitive function and behavior. This review highlights some the latest advances in understanding astrocyte roles different behavioral domains across lifespan disease. We address specific molecular circuit mechanisms by which astrocytes modulate behavior, discuss their functional diversity versatility, highlight astrocyte-targeted treatment strategies that might alleviate dysfunction pathologic conditions. Converging evidence model systems manipulations is revealing regulate processes a precise context-dependent manner. Improved these astrocytic functions may generate new therapeutic for various conditions with impairments.

Язык: Английский

Процитировано

11

Reward Expectation Reduces Representational Drift in the Hippocampus DOI Creative Commons
Seetha Krishnan, Mark Sheffield

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 22, 2023

Spatial memory in the hippocampus involves dynamic neural patterns that change over days, termed representational drift. While drift may aid updating, excessive could impede retrieval. Memory retrieval is influenced by reward expectation during encoding, so we hypothesized diminished would exacerbate We found high limited drift, with CA1 representations on one day gradually re-emerging successive trials following day. Conversely, absence of resulted increased as gradual re-emergence previous day's representation did not occur. At single cell level, lowering caused an immediate increase proportion place-fields low trial-to-trial reliability. These place fields were less likely to be reinstated day, underlying this condition. In conclusion, heightened improves encoding and maintaining reliable are across thereby minimizing

Язык: Английский

Процитировано

10

Neurodynamic behavior of hippocampal CA1 neuron model driven by external current stimulation DOI
Guizhi Xu, Huan Liu, Youxi Wu

и другие.

Chinese Journal of Physics, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

The Role of Glutamatergic Neurons in Changes of Synaptic Plasticity Induced by THz Waves DOI Creative Commons

Lequan Song,

Ji Dong, Wenjing Cheng

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 532 - 532

Опубликована: Апрель 4, 2025

Background: Terahertz (THz) waves, lying between millimeter waves and infrared light, may interact with biomolecules due to their unique energy characteristics. However, whether THz are neurally regulated remains controversial, the underlying mechanism is elusive. Methods: Mouse brain slices were exposed 1.94 for 1 h. Synaptic plasticity was evaluated via transmission electron microscopy (TEM), long-term potentiation (LTP), neuronal class III β-tubulin (Tuj1) synaptophysin (SYN) expression. Immunofluorescence (IF) electrophysiology used identify neurons sensitive waves. The calcium activity of excitatory neurons, glutamate receptor currents, neuron marker expression also assessed using imaging, a patch clamp, Western blotting (WB). Optogenetics chemogenetics determine role in synaptic impairment after wave exposure. NMDA 2B (GluN2B) overexpressed ventral hippocampal CA1 (vCA1) by lentivirus clarify GluN2B wave-induced impairment. Results: Exposure increased postsynaptic density (PSD) thickness reduced field potential (fEPSP) slope Tuj1 SYN diminished vCA1 glutamatergic excitability, neural electrical activity, transporter function. N-methyl-D-aspartate (NMDAR) current amplitudes NMDAR subunit Activating through optogenetics mitigated overexpression improved expression, ultrastructure, fEPSP slope. Conclusions: decreased plasticity, vCA1. Glutamatergic activation alleviated impairment; thus, neuromodulation could be promising therapeutic strategy mitigate adverse effects radiation.

Язык: Английский

Процитировано

0

Hippocampal-subfield macro- and microstructural changes in cerebral small vessel disease with mild cognitive impairment DOI
Binglan Li,

Bang Zeng,

Peng Zeng

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер 384, С. 12 - 22

Опубликована: Май 6, 2025

Язык: Английский

Процитировано

0

Dorsal raphe nucleus–hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice DOI Creative Commons
Meiqin Chen, Chenlu Wang,

Yinan Lin

и другие.

Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)

Опубликована: Июль 24, 2024

Abstract Background Depressive symptoms often occur in patients with Alzheimer's disease (AD) and exacerbate the pathogenesis of AD. However, neural circuit mechanisms underlying AD-associated depression remain unclear. The serotonergic system plays crucial roles both AD depression. Methods We used a combination vivo trans-synaptic circuit-dissecting anatomical approaches, chemogenetic manipulations, optogenetic pharmacological methods, behavioral testing, electrophysiological recording to investigate dorsal raphe nucleus mouse model. Results found that activity serotonin neurons (DRN 5-HT ) their projections hippocampal CA1 (dCA1) terminals -dCA1 CaMKII decreased brains early 5×FAD mice. Chemogenetic or activation DRN attenuated depressive cognitive impairments mice through receptor 1B (5-HT R) 4 R). Pharmacological R by regulating improve synaptic plasticity. Conclusions These findings provide new mechanistic connection between potential pharmaceutical prevention targets for

Язык: Английский

Процитировано

2