Neuropeptide Modulation Enables Biphasic Internetwork Coordination via a Dual-Network Neuron DOI Creative Commons
Barathan Gnanabharathi, Savanna-Rae H. Fahoum, Dawn M. Blitz

и другие.

eNeuro, Год журнала: 2024, Номер 11(6), С. ENEURO.0121 - 24.2024

Опубликована: Июнь 1, 2024

Linked rhythmic behaviors, such as respiration/locomotion or swallowing/chewing, often require coordination for proper function. Despite its prevalence, the cellular mechanisms controlling of underlying neural networks remain undetermined in most systems. We use stomatogastric nervous system crab Cancer borealis to investigate internetwork coordination, due small, well-characterized feeding-related (gastric mill [chewing, ∼0.1 Hz]; pyloric [filtering food, ∼1 Hz]). Here, we between these during Gly 1 -SIFamide neuropeptide modulatory state. activates a unique triphasic gastric rhythm which typically pyloric-only LPG neuron generates dual pyloric-plus mill-timed oscillations. Additionally, exhibits shorter cycles rhythm-timed bursts, and longer IC, IC plus LG bursts. Photoinactivation revealed that is necessary shorten cycle period, likely through rectified electrical coupling pacemaker neurons. Hyperpolarizing current injections demonstrated although bursting enables only bursts are prolong period. Surprisingly, photoinactivation also eliminated prolonged cycles, without changing firing frequency burst duration, suggesting via synaptic inhibition LPG, indirectly slows pacemakers coupling. Thus, same dual-network directly conveys excitation from endogenous funnels enable one network alternately decrease increase period related network.

Язык: Английский

Head kinematic variability is minimal near preferred cadence and independent of the vestibular control of locomotion DOI Creative Commons
Liam H. Foulger, Calvin Kuo, Romeo Chua

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 28, 2025

Язык: Английский

Процитировано

0
Neuropeptide Modulation Enables Biphasic Inter-network Coordination via a Dual-Network Neuron DOI Creative Commons
Barathan Gnanabharathi, Savanna-Rae H. Fahoum, Dawn M. Blitz

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 20, 2024

Abstract Linked rhythmic behaviors, such as respiration/locomotion or swallowing/chewing often require coordination for proper function. Despite its prevalence, the cellular mechanisms controlling of underlying neural networks remain undetermined in most systems. We use stomatogastric nervous system crab Cancer borealis to investigate inter-network coordination, due small, well characterized feeding-related (gastric mill [chewing, ∼0.1 Hz]; pyloric [filtering food, ∼1 Hz]). Here, we between these during Gly 1 -SIFamide neuropeptide modulatory state. activates a unique triphasic gastric rhythm which typically pyloric-only LPG neuron generates dual pyloric- plus mill-timed oscillations. Additionally, exhibits shorter cycles rhythm-timed bursts, and longer IC, IC LG bursts. Photoinactivation revealed that is necessary shorten cycle period, likely through rectified electrical coupling pacemaker neurons. Hyperpolarizing current injections demonstrated although bursting enables only bursts are prolong period. Surprisingly, photoinactivation also eliminated prolonged cycles, without changing firing frequency burst duration, suggesting via synaptic inhibition LPG, indirectly slows pacemakers coupling. Thus, same dual-network directly conveys excitation from endogenous funnels enable one network alternately decrease increase period related network. Significance Statement Related behaviors frequently exhibit yet coordinating not determined investigated two well-characterized crustacean feeding-associated neuropeptide-elicited find fast/slow shortens fast slow, intrinsically generated pacemakers, despite rectification favoring opposite direction. another slow-network phase, chemical funneled synapse. reinforces diminishes actions, enabling distinct frequencies faster across different phases slower rhythm.

Язык: Английский

Процитировано

2
Steering From the Rear: Coordination of Central Pattern Generators Underlying Navigation by Ascending Interneurons DOI Creative Commons
Julius Jonaitis, Karen L Hibbard,

Kaity McCafferty Layte

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 17, 2024

ABSTRACT Understanding how animals coordinate movements to achieve goals is a fundamental pursuit in neuroscience. Here we explore neurons that reside posterior lower-order regions of locomotor system project anterior higher-order influence steering and navigation. We characterized the anatomy functional role population ascending interneurons ventral nerve cord Drosophila larvae. Through electron microscopy reconstructions light microscopy, determined cholinergic 19f cells receive input primarily from premotor synapse upon diverse array postsynaptic targets within segments including other cells. Calcium imaging activity isolated central nervous (CNS) preparations relation motor revealed are recruited into most larval programmes. lags behind neuron as population, encode spatio-temporal patterns CNS. Optogenetic manipulations cell CNS they pattern generators underlying exploratory headsweeps forward locomotion context location specific manner. In behaving animals, activating suppressed slowed locomotion, while inhibition potentiated headsweeps, slowing movement. Inhibiting ultimately affected ability larvae remain vicinity an odor source during olfactory navigation task. Overall, our findings provide insights monitor shape interactions amongst rhythm complex navigational tasks.

Язык: Английский

Процитировано

2
Neuropeptide Modulation Enables Biphasic Internetwork Coordination via a Dual-Network Neuron DOI Creative Commons
Barathan Gnanabharathi, Savanna-Rae H. Fahoum, Dawn M. Blitz

и другие.

eNeuro, Год журнала: 2024, Номер 11(6), С. ENEURO.0121 - 24.2024

Опубликована: Июнь 1, 2024

Linked rhythmic behaviors, such as respiration/locomotion or swallowing/chewing, often require coordination for proper function. Despite its prevalence, the cellular mechanisms controlling of underlying neural networks remain undetermined in most systems. We use stomatogastric nervous system crab Cancer borealis to investigate internetwork coordination, due small, well-characterized feeding-related (gastric mill [chewing, ∼0.1 Hz]; pyloric [filtering food, ∼1 Hz]). Here, we between these during Gly 1 -SIFamide neuropeptide modulatory state. activates a unique triphasic gastric rhythm which typically pyloric-only LPG neuron generates dual pyloric-plus mill-timed oscillations. Additionally, exhibits shorter cycles rhythm-timed bursts, and longer IC, IC plus LG bursts. Photoinactivation revealed that is necessary shorten cycle period, likely through rectified electrical coupling pacemaker neurons. Hyperpolarizing current injections demonstrated although bursting enables only bursts are prolong period. Surprisingly, photoinactivation also eliminated prolonged cycles, without changing firing frequency burst duration, suggesting via synaptic inhibition LPG, indirectly slows pacemakers coupling. Thus, same dual-network directly conveys excitation from endogenous funnels enable one network alternately decrease increase period related network.

Язык: Английский

Процитировано

0