Frontiers in Psychology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 27, 2025
In
at-risk
societies,
the
population
of
post-traumatic
stress
disorder
(PTSD)
incidence
is
gradually
expanding
from
veterans
to
general
public.
face
high
PTSD,
exercise
therapy,
as
an
economical
and
maneuverable
treatment,
has
not
received
attention
it
deserves.
this
paper,
literature
on
PTSD
symptom
improvement
through
comb-climbing
interventions
found
that
performing
long-term
can
achieve
significant
in
symptoms
by
modulating
central
nervous
system,
autonomic
immune
system
at
physiological
level.
Aerobic
(running,
walking)
beneficial
system;
anaerobic
positively
affects
including
resistance
or
strength
endurance
training;
yoga,
which
focuses
flexibility
balance
training,
a
positive
effect
system.
Future
research
should
explore
neutral
negative
effects
mechanisms
interventions.
Expand
more
empirical
studies
special
occupational
populations.
And
implement
longitudinal
intervention
with
patients
gain
in-depth
understanding
effects.
AJP Endocrinology and Metabolism,
Год журнала:
2020,
Номер
319(1), С. E48 - E66
Опубликована: Апрель 21, 2020
Although
glucocorticoid
resistance
contributes
to
increased
inflammation,
individuals
with
posttraumatic
stress
disorder
(PTSD)
exhibit
receptor
(GR)
sensitivity
along
inflammation.
It
is
not
clear
how
inflammation
coexists
a
hyperresponsive
hypothalamic-pituitary-adrenal
(HPA)
axis.
To
understand
this
better,
we
developed
and
analyzed
an
integrated
mathematical
model
for
the
HPA
axis
immune
system.
We
performed
simulations
dexamethasone
(DEX)
suppression
test
IC50-dexamethasone
cytokine
by
varying
parameters.
The
analysis
suggests
that
increasing
steepness
of
dose-response
curve
GR
activity
may
reduce
anti-inflammatory
effects
GRs
at
ambient
levels,
thereby
proinflammatory
response.
adaptive
response
cytokine-mediated
stimulatory
on
reduced
due
dominance
GR-mediated
negative
feedback
verify
these
hypotheses,
clinical
data
neuroendocrine
variables
cytokines
obtained
from
war-zone
veterans
without
PTSD.
observed
significant
group
differences
cortisol
ACTH
tests,
TNFα
IL6,
high-sensitivity
C-reactive
protein,
promoter
methylation
gene,
IC50-DEX
lysozyme
suppression.
Causal
inference
modeling
revealed
associations
between
post-DEX
decline,
human
gene
exon
1F
(NR3C1-1F),
IC50-DEX,
cytokines.
noted
mediation
NR3C1-1F
inflammatory
through
changes
in
sensitivity.
Our
findings
suggest
contribute
inflammation;
therefore,
interventions
restore
normalize
European Journal of Neuroscience,
Год журнала:
2021,
Номер
55(9-10), С. 2253 - 2296
Опубликована: Июнь 25, 2021
Childhood
trauma
(CT)
is
well
established
as
a
potent
risk
factor
for
the
development
of
mental
disorders.
However,
potential
adverse
early
experiences
to
exert
chronic
and
profound
effects
on
physical
health,
including
aberrant
metabolic
phenotypes,
has
only
been
more
recently
explored.
Among
these
consequences
syndrome
(MetS),
which
characterised
by
at
least
three
five
related
cardiometabolic
traits:
hypertension,
insulin
resistance/hyperglycaemia,
raised
triglycerides,
low
high-density
lipoprotein
central
obesity.
The
deleterious
CT
health
outcomes
may
be
partially
attributable
dysregulation
hypothalamic-pituitary-adrenal
(HPA)
axis,
coordinates
response
stress,
consequent
fostering
pro-inflammatory
environment.
Epigenetic
tags,
such
DNA
methylation,
are
sensitive
environmental
influences
provide
means
whereby
can
biologically
embedded
persist
into
adulthood
affect
well-being.
methylome
regulates
transcription
genes
involved
in
stress
response,
metabolism
inflammation.
This
narrative
review
examines
evidence
methylation
MetS
order
identify
shared
neuroendocrine
immune
correlates
that
mediate
increased
following
exposure.
Our
specifically
highlights
differential
FKBP5,
gene
encodes
FK506-binding
protein
51
pleiotropic
responding,
inflammation
energy
metabolism,
candidate
understand
molecular
aetiology
underlying
CT-associated
risk.
Translational Psychiatry,
Год журнала:
2022,
Номер
12(1)
Опубликована: Апрель 14, 2022
Alterations
of
the
hypothalamus
pituitary-axis
on
one
hand
and
heightened
rates
somatic
diseases
mortality
other
are
consistently
found
for
PTSD
MDD
patients.
A
possible
link
between
these
factors
might
be
immune
system,
in
particular
pro-
anti-inflammatory
cytokines.
'low-grade
inflammation'
patients
was
found,
whereas
influence
acute
stress
role
cytokines
rarely
examined.
In
this
study,
17
female
participated
Trier
social
test
while
serum
cytokine
levels
(IL-6,
IL-10)
were
assessed.
Cytokine
compared
with
depressive
(n
=
18)
healthy
controls
18).
Group
differences
assessed
using
a
3
(group)
x
8
(time:
-15,
-1,
+1,
+10,
+20,
+30,
+45,
+60
min)
ANCOVA
repeated
measures
baseline
values
as
covariates.
There
no
group
difference
regarding
IL-6
(p
0.920)
but
showed
significantly
higher
IL-10
<
0.001,
d
0.16)
0.38).
Under
stress,
did
not
show
widely
elevated
an
increase
IL-10.
Therefore,
seems
to
promote
imbalance
indicate
hyperreactive
response.
This
should
considered
future
studies
further
understand
system
response
diseases.
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 507 - 507
Опубликована: Фев. 18, 2025
Post-traumatic
stress
disorder
(PTSD),
a
mental
caused
by
exposure
to
traumatic
stress,
affects
5-10%
of
the
world's
population.
There
is
some
evidence
that
PTSD
associated
with
accelerated
cellular
aging,
leading
an
increased
risk
medical
and
neurodegenerative
comorbidities.
Alterations
in
telomere
length
(TL)
telomerase
enzyme
activity
have
been
proposed
as
biomarkers
this
process.
This
hypothesis
was
seemingly
confirmed
preliminary
research,
but
more
recent
studies
yielded
mixed
results.
The
current
narrative
review
conducted
provide
critical
synthesis
existing
research
on
PTSD.
Data
from
26
clinical
suggest
TL
highly
variable
may
be
influenced
methodological,
demographic,
trauma-related,
psychosocial
factors.
no
for
altered
In
contrast,
animal
suggests
does
lead
shortening.
Overall,
it
likely
not,
itself,
reliable
biomarker
aging
Other
markers
senescence,
such
epigenetic
changes,
prove
specific
measuring
process
patients
