Journal of Neural Transmission, Год журнала: 2021, Номер 128(9), С. 1301 - 1310
Опубликована: Май 14, 2021
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5238 - 5238
Опубликована: Март 9, 2023
Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling condition resulting in reduced quality of life increased economic burden. The is directly related to exposure traumatic event, e.g., real or threatened injury, death, sexual assault. Extensive research has been done on the neurobiological alterations underlying its phenotypes, revealing brain circuit disruption, neurotransmitter dysregulation, hypothalamic–pituitary–adrenal (HPA) axis dysfunction. Psychotherapy remains first-line treatment option for PTSD given good efficacy, although pharmacotherapy also be used as stand-alone combination with psychotherapy. In order reduce prevalence burden disorder, multilevel models prevention have developed detect early possible morbidity those established diseases. Despite clinical grounds diagnosis, attention increasing discovery reliable biomarkers that predict susceptibility, aid monitor treatment. Several potential linked pathophysiological changes PTSD, encouraging further identify actionable targets. This review highlights current literature regarding pathophysiology, disease development models, modalities, preventive from public health perspective, discusses state biomarker research.
Язык: Английский
Процитировано
51
Translational Psychiatry, Год журнала: 2021, Номер 11(1)
Опубликована: Июль 10, 2021
Abstract In neuroscience, the term ‘Stress’ has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in face exposure stress, more common reaction stress is resilience, indicating that resilience rule and stress-related pathology exception. This critical neural mechanisms associated with psychopathology are expected differ significantly from those resilience. Research labels terminology affect research directions, conclusions drawn results, way we think about topic, while choice often influenced by biases hidden assumptions. It therefore important adopt differentiates between conditions, leading different outcomes. Here, propose conceptually associate ‘stress’/‘stressful experience’ ‘stress resilience’, restricting use ‘trauma’ only reference exposures lead pathology. We acknowledge there as yet no ideal ways for addressing murkiness border stressful traumatic experiences. ignoring these differences hampers our ability elucidate trauma-related pathologies on one hand, other. Accordingly, discuss how translate such conceptual into practice.
Язык: Английский
Процитировано
56
Nature Neuroscience, Год журнала: 2022, Номер 25(11), С. 1434 - 1445
Опубликована: Окт. 20, 2022
Abstract Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to which genetic and environmental risk factors contribute individual clinical outcomes is unknown. Here, we compared transcriptional responses hydrocortisone exposure in human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons peripheral blood mononuclear cells (PBMCs) from combat veterans with PTSD ( n = 19 hiPSC 20 PBMC donors) controls donors). In only, observed diagnosis-specific glucocorticoid-induced changes gene expression corresponding PTSD-specific transcriptomic patterns found postmortem brains. We glucocorticoid hypersensitivity neurons, identified genes that this PTSD-dependent response. find evidence of a coregulated network transcription mediates hyper-responsivity PTSD. These findings suggest represent platform for examining molecular mechanisms underlying PTSD, identifying biomarkers response, conducting drug screening identify new therapeutics.
Язык: Английский
Процитировано
41
Autonomic Neuroscience, Год журнала: 2024, Номер 252, С. 103159 - 103159
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
8
Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 147, С. 105101 - 105101
Опубликована: Фев. 17, 2023
Язык: Английский
Процитировано
18
Brain Behavior & Immunity - Health, Год журнала: 2024, Номер 41, С. 100849 - 100849
Опубликована: Авг. 23, 2024
Язык: Английский
Процитировано
7
Journal of Psychiatric Research, Год журнала: 2020, Номер 130, С. 112 - 119
Опубликована: Авг. 2, 2020
Язык: Английский
Процитировано
42
Advances in experimental medicine and biology, Год журнала: 2023, Номер unknown, С. 225 - 262
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
14
Translational Psychiatry, Год журнала: 2024, Номер 14(1)
Опубликована: Янв. 10, 2024
Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or stress and potential novel psychological various brain, somatic, psychiatric disorders. No studies have yet analyzed ccf-mtDNA levels in post-traumatic disorder (PTSD), despite evidence dysfunction this condition. In the current study, we compared plasma combat trauma-exposed male veterans with PTSD (n = 111) those who did not develop 121) also investigated relationship between ccf mt-DNA glucocorticoid sensitivity. unadjusted analyses, differ significantly non-PTSD groups (t 1.312, p 0.191, Cohen's d 0.172). sensitivity analysis excluding participants diabetes using antidepressant medication controlling for age, group had lower than (F(1, 179) 5.971, 0.016, partial η
Язык: Английский
Процитировано
5
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 158, С. 105566 - 105566
Опубликована: Фев. 2, 2024
Язык: Английский
Процитировано
5