Protein and Peptide Letters,
Год журнала:
2023,
Номер
30(8), С. 626 - 639
Опубликована: Июль 7, 2023
Bioactive
peptides
obtained
from
natural
resources
are
useful
due
to
their
ability
prevent
the
risk
of
dreadful
conditions
such
as
hypertension,
cancers,
obesity
and
cardiovascular
diseases.
Proteins
food,
plants,
animals
dairy
products
chemically
or
enzymatically
hydrolyzed
fermented
in
presence
microbes
produce
bioactive
peptides.
antioxidant,
antihypertensive,
anti-inflammatory,
antiproliferative,
antibacterial,
anticancer,
antimicrobial
some
them
also
show
multiple
bioactivities.
Also,
offer
much
potential
nutraceuticals
functional
food
components.
This
paper
reviews
recent
progress
(2020-2022)
on
derived
animals,
products.
Emphasis
is
given
production,
purification,
use
for
health
promotions
medicinal
applications.
Foods,
Год журнала:
2025,
Номер
14(7), С. 1256 - 1256
Опубликована: Апрель 3, 2025
Our
previous
research
has
shown
that
SDOs
derived
from
yellow
silk
cocoons
have
hypotensive
effects
on
rats
in
chronic
toxicity
testing.
This
study
investigated
the
potential
preventative
and
therapeutic
benefits
of
hypertensive
induced
by
L-NAME.
The
experiment
involved
nine
rat
groups:
(1)
normal
control,
(2)
+
200
mg
kg-1
BW
SDOs,
(3)
(HT)
(4)
HT
50
(5)
100
(6)
(7)
enalapril
(Ena),
(8)
soy
protein
isolate
(SPI),
(9)
bovine
serum
albumin
(BSA).
In
approach,
received
40
L-NAME
with
studied
substances
during
four-week
investigation.
given
at
doses
demonstrated
a
significant
decrease
systolic
blood
pressure
(SBP)
without
affecting
heart
rate
(HR).
studies,
increased
SBP
experimental
groups
over
first
four
weeks,
resulting
mean
values
above
150
mmHg.
Administering
SPI
significantly
reduced
SBP.
However,
exhibited
closer
to
group.
functional
vascular
tests,
dose
had
highest
relaxation
lowest
contraction
percentages,
like
control
groups.
found
may
inhibit
manage
hypertension
both
healthy
safeguarding
endothelial
cells.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
63(27), С. 8823 - 8838
Опубликована: Апрель 28, 2022
Soybean
functional
peptides
(SFPs)
are
obtained
via
the
hydrolysis
of
soybean
protein
into
polypeptides,
oligopeptides,
and
a
small
amount
amino
acids.
They
have
nutritional
value
variety
properties,
including
regulating
blood
lipids,
lowering
pressure,
anti-diabetes,
anti-oxidant,
preventing
COVID-19,
etc.
SFPs
potential
application
prospects
in
food
processing,
development,
clinical
medicine,
infant
milk
powder,
special
medical
formulations,
among
others.
However,
bitter
containing
relatively
more
hydrophobic
acids
can
be
formed
during
production
SFPs,
seriously
restricting
SFPs.
High-quality
confirmatory
human
trials
needed
to
determine
effective
doses,
risks,
mechanisms
action,
especially
as
dietary
supplements
formulations.
Therefore,
physiological
activities
risks
polypeptides
summarized,
existing
debitterness
technologies
their
applicability
reviewed.
The
technical
challenges
research
areas
addressed
optimizing
debittering
process
parameters
improving
discussed,
integrating
various
obtain
higher
quality
peptides,
which
will
facilitate
further
exploration
mechanism,
metabolic
pathway,
tolerance,
bioavailability,
hazards
This
review
help
promote
development
industry.
Foods,
Год журнала:
2022,
Номер
11(22), С. 3626 - 3626
Опубликована: Ноя. 13, 2022
Inhibition
of
dipeptidyl
peptidase-4
(DPP-4)
is
an
effective
way
to
control
blood
glucose
in
diabetic
patients.
Tenebrio
(T.)
molitor
edible
insect
containing
abundant
protein.
T.
protein-derived
peptides
can
suppress
the
DPP-4
activity.
However,
amino
acid
sequence
and
binding
mechanism
these
inhibitory
remain
unclear.
This
study
used
flavourzyme
for
protein
hydrolysis,
identified
released
with
effect,
investigated
interactions
DPP-4.
The
results
showed
that
efficiently
hydrolyzed
protein,
as
demonstrated
by
high
degree
disappearance
bands
SDS-PAGE,
changes
structure.
4-h
hydrolysates
a
good
effect
on
(IC50
value
1.64
mg/mL).
fragment
1000-3000
Da
accounted
10.39%
total
peptides,
but
strongest
LPDQWDWR
APPDGGFWEWGD
were
from
this
fraction,
their
IC50
values
against
0.15
1.03
mg/mL,
respectively.
Molecular
docking
two
interacted
active
site
via
hydrogen
bonding,
hydrophobic
interactions,
salt
bridge
formation,
π-cation
π-π
stacking.
Our
findings
indicated
could
be
natural
inhibitors.
Food & medicine homology.,
Год журнала:
2024,
Номер
1(2), С. 9420023 - 9420023
Опубликована: Авг. 15, 2024
Soybean
protease
hydrolysate
(SPH)
contains
abundant
antihypertensive
peptides,
yet
the
sequence
defining
vital
peptides
is
unclear.
Peptiomics
sequencing
analyzed
in
enzymatic
products
from
soybean
protein
alkaline
and
flavor
proteases.
Database
queries
simulations
screened
key
peptide
monomers,
assessing
angiotensin-converting
enzyme
(ACE)
inhibitory
activities
in
vitro.
Peptidomics
identified
6,980
short
SPH,
predominantly
hydrophobic
at
N-terminal.
Sixty-eight
were
target
assessed
for
allergenicity,
toxicity,
physicochemical
properties.
Pentapeptide
WGPRL
tetrapeptide
WLRL
exhibited
optimal
ACE
inhibition,
deemed
non-competitive.
ADMET
characteristics
indicated
good
water
solubility
human
intestinal
absorption,
suggesting
potential
as
drugs
or
functional
food
ingredients.
The
impact
of
a
novel
on
Ang
II-induced
vascular
smooth
muscle
cell
dysfunction
was
explored.
significantly
inhibited
over-proliferation
migration.
These
findings
that
potent
SPH
enriched
with
pentapeptide
has
effective
components
food.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Ноя. 24, 2022
Angiotensin-converting
enzyme
I
(ACE
I)
is
a
zinc-containing
metallopeptidase
involved
in
the
renin-angiotensin
system
(RAAS)
that
helps
regulation
of
hypertension
and
maintains
fluid
balance
otherwise,
which
results
cardiovascular
diseases
(CVDs).
One
leading
reasons
global
deaths
due
to
CVDs.
RAAS
also
plays
central
role
maintaining
homeostasis
CV
system.
The
commercial
drugs
available
treat
CVDs
possess
several
fatal
side
effects.
Hence,
phytochemicals
like
peptides
having
plant-based
origin
should
be
explored
utilized
as
alternative
therapies.
Soybean
an
important
leguminous
crop
simultaneously
possesses
medicinal
properties.
extracts
are
used
many
drug
formulations
for
treating
diabetes
other
disorders
ailments.
Soy
proteins
its
edible
products
such
tofu
have
shown
potential
inhibitory
activity
against
ACE.
Thus,
this
review
briefly
describes
various
soy
can
inhibit
ACE
thereby
providing
new
scope
identification
candidates
help
design
safer
natural
treatments
