RNA and condensates: Disease implications and therapeutic opportunities
Cell chemical biology,
Год журнала:
2024,
Номер
31(9), С. 1593 - 1609
Опубликована: Сен. 1, 2024
Язык: Английский
Stress Granules in Atherosclerosis: Insights and Therapeutic Opportunities
Sahar Naseem,
Lijuan Sun,
Juhui Qiu
и другие.
Current Problems in Cardiology,
Год журнала:
2024,
Номер
49(10), С. 102760 - 102760
Опубликована: Июль 24, 2024
Язык: Английский
Epitranscriptomic modifications for enhancing abiotic stress resistance in plants
Frontiers in Plant Science,
Год журнала:
2025,
Номер
16
Опубликована: Май 23, 2025
Climate
change
significantly
impedes
agricultural
growth,
development,
and
production.
Plants
adapt
to
environmental
changes
via
the
plasticity
given
by
essential
genes,
which
are
regulated
at
post-/transcriptional
level.
Gene
regulation
in
plants
is
a
complex
process
governed
various
cellular
entities,
including
transcription
factors,
epigenetic
regulators,
non-coding
RNAs.
Successful
studies
have
confirmed
function
of
alterations
such
as
DNA
methylation/histone
modification)
gene
expression.
In
recent
years,
highly
specialized
science
known
“Epitranscriptomics”
has
emerged.
Epitranscriptomics
post-transcriptional
RNA
chemical
seen
all
living
organisms
that
alter
RNA’s
structural,
functional,
biological
properties.
Our
minireview
interpreted
about
understanding
molecular
pathways:
stress-responsive
regulation.
Additionally,
interplay
between
epitranscriptomics
other
regulatory
levels
been
addressed.
addition,
we
reviewed
technical
breakthroughs
epitranscriptomic
research,
tools
techniques.
Язык: Английский
Decoding the interplay between m 6 A modification and stress granule stability by live-cell imaging
Science Advances,
Год журнала:
2024,
Номер
10(46)
Опубликована: Ноя. 15, 2024
N
6
-methyladenosine
(m
A)–modified
mRNAs
and
their
cytoplasmic
reader
YTHDFs
are
colocalized
with
stress
granules
(SGs)
under
conditions,
but
the
interplay
between
m
A
modification
SG
stability
remains
unclear.
Here,
we
presented
a
spatiotemporal
imaging
system
(SMIS)
that
can
monitor
translation
of
high
specificity
sensitivity
in
single
live
cell.
SMIS
showed
A-modified
reporter
dynamically
enriched
into
SGs
arsenite
gradually
partitioned
cytosol
as
disassembled.
revealed
knockdown
YTHDF2
contributed
to
disassembly,
resulting
fast
redistribution
from
rapid
recovery
stalled
translation.
The
mechanism
is
regulate
through
interaction
G3BP1
RNA-dependent
manner.
Our
results
suggest
for
regulation.
Язык: Английский