Decoding the interplay between m 6 A modification and stress granule stability by live-cell imaging DOI Creative Commons
Qianqian Li, Jian K. Liu,

Liping Guo

и другие.

Science Advances, Год журнала: 2024, Номер 10(46)

Опубликована: Ноя. 15, 2024

N 6 -methyladenosine (m A)–modified mRNAs and their cytoplasmic reader YTHDFs are colocalized with stress granules (SGs) under conditions, but the interplay between m A modification SG stability remains unclear. Here, we presented a spatiotemporal imaging system (SMIS) that can monitor translation of high specificity sensitivity in single live cell. SMIS showed A-modified reporter dynamically enriched into SGs arsenite gradually partitioned cytosol as disassembled. revealed knockdown YTHDF2 contributed to disassembly, resulting fast redistribution from rapid recovery stalled translation. The mechanism is regulate through interaction G3BP1 RNA-dependent manner. Our results suggest for regulation.

Язык: Английский

RNA and condensates: Disease implications and therapeutic opportunities DOI Creative Commons

Tina W. Han,

Bede Portz, Richard A. Young

и другие.

Cell chemical biology, Год журнала: 2024, Номер 31(9), С. 1593 - 1609

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

7
Stress Granules in Atherosclerosis: Insights and Therapeutic Opportunities DOI

Sahar Naseem,

Lijuan Sun,

Juhui Qiu

и другие.

Current Problems in Cardiology, Год журнала: 2024, Номер 49(10), С. 102760 - 102760

Опубликована: Июль 24, 2024

Язык: Английский

Процитировано

3
Epitranscriptomic modifications for enhancing abiotic stress resistance in plants DOI Creative Commons
Yunmin Zeng, Muhammad Abid, Lingyun Wan

и другие.

Frontiers in Plant Science, Год журнала: 2025, Номер 16

Опубликована: Май 23, 2025

Climate change significantly impedes agricultural growth, development, and production. Plants adapt to environmental changes via the plasticity given by essential genes, which are regulated at post-/transcriptional level. Gene regulation in plants is a complex process governed various cellular entities, including transcription factors, epigenetic regulators, non-coding RNAs. Successful studies have confirmed function of alterations such as DNA methylation/histone modification) gene expression. In recent years, highly specialized science known “Epitranscriptomics” has emerged. Epitranscriptomics post-transcriptional RNA chemical seen all living organisms that alter RNA’s structural, functional, biological properties. Our minireview interpreted about understanding molecular pathways: stress-responsive regulation. Additionally, interplay between epitranscriptomics other regulatory levels been addressed. addition, we reviewed technical breakthroughs epitranscriptomic research, tools techniques.

Язык: Английский

Процитировано

0
Decoding the interplay between m 6 A modification and stress granule stability by live-cell imaging DOI Creative Commons
Qianqian Li, Jian K. Liu,

Liping Guo

и другие.

Science Advances, Год журнала: 2024, Номер 10(46)

Опубликована: Ноя. 15, 2024

N 6 -methyladenosine (m A)–modified mRNAs and their cytoplasmic reader YTHDFs are colocalized with stress granules (SGs) under conditions, but the interplay between m A modification SG stability remains unclear. Here, we presented a spatiotemporal imaging system (SMIS) that can monitor translation of high specificity sensitivity in single live cell. SMIS showed A-modified reporter dynamically enriched into SGs arsenite gradually partitioned cytosol as disassembled. revealed knockdown YTHDF2 contributed to disassembly, resulting fast redistribution from rapid recovery stalled translation. The mechanism is regulate through interaction G3BP1 RNA-dependent manner. Our results suggest for regulation.

Язык: Английский

Процитировано

0