Decoding the interplay between m 6 A modification and stress granule stability by live-cell imaging DOI Creative Commons
Qianqian Li, Jian K. Liu, Liping Guo

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(46)

Published: Nov. 15, 2024

N 6 -methyladenosine (m A)–modified mRNAs and their cytoplasmic reader YTHDFs are colocalized with stress granules (SGs) under conditions, but the interplay between m A modification SG stability remains unclear. Here, we presented a spatiotemporal imaging system (SMIS) that can monitor translation of high specificity sensitivity in single live cell. SMIS showed A-modified reporter dynamically enriched into SGs arsenite gradually partitioned cytosol as disassembled. revealed knockdown YTHDF2 contributed to disassembly, resulting fast redistribution from rapid recovery stalled translation. The mechanism is regulate through interaction G3BP1 RNA-dependent manner. Our results suggest for regulation.

Language: Английский

RNA and condensates: Disease implications and therapeutic opportunities DOI Creative Commons

Tina W. Han,

Bede Portz, Richard A. Young

et al.

Cell chemical biology, Journal Year: 2024, Volume and Issue: 31(9), P. 1593 - 1609

Published: Sept. 1, 2024

Language: Английский

Citations

6
Epitranscriptomic modifications for enhancing abiotic stress resistance in plants DOI Creative Commons
Yunmin Zeng, Muhammad Abid, Lingyun Wan

et al.

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16

Published: May 23, 2025

Climate change significantly impedes agricultural growth, development, and production. Plants adapt to environmental changes via the plasticity given by essential genes, which are regulated at post-/transcriptional level. Gene regulation in plants is a complex process governed various cellular entities, including transcription factors, epigenetic regulators, non-coding RNAs. Successful studies have confirmed function of alterations such as DNA methylation/histone modification) gene expression. In recent years, highly specialized science known “Epitranscriptomics” has emerged. Epitranscriptomics post-transcriptional RNA chemical seen all living organisms that alter RNA’s structural, functional, biological properties. Our minireview interpreted about understanding molecular pathways: stress-responsive regulation. Additionally, interplay between epitranscriptomics other regulatory levels been addressed. addition, we reviewed technical breakthroughs epitranscriptomic research, tools techniques.

Language: Английский

Citations

0
Stress Granules in Atherosclerosis: Insights and Therapeutic Opportunities DOI

Sahar Naseem,

Lijuan Sun,

Juhui Qiu

et al.

Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: 49(10), P. 102760 - 102760

Published: July 24, 2024

Language: Английский

Citations

3
Decoding the interplay between m 6 A modification and stress granule stability by live-cell imaging DOI Creative Commons
Qianqian Li, Jian K. Liu, Liping Guo

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(46)

Published: Nov. 15, 2024

N 6 -methyladenosine (m A)–modified mRNAs and their cytoplasmic reader YTHDFs are colocalized with stress granules (SGs) under conditions, but the interplay between m A modification SG stability remains unclear. Here, we presented a spatiotemporal imaging system (SMIS) that can monitor translation of high specificity sensitivity in single live cell. SMIS showed A-modified reporter dynamically enriched into SGs arsenite gradually partitioned cytosol as disassembled. revealed knockdown YTHDF2 contributed to disassembly, resulting fast redistribution from rapid recovery stalled translation. The mechanism is regulate through interaction G3BP1 RNA-dependent manner. Our results suggest for regulation.

Language: Английский

Citations

0