Current Opinion in Virology,
Год журнала:
2021,
Номер
52, С. 211 - 216
Опубликована: Дек. 24, 2021
Host
silencing
of
transposable
elements
(TEs)
is
critical
to
prevent
genome
damage
and
inappropriate
inflammation.
However,
new
evidence
suggests
that
a
virus-infected
host
may
re-activate
TEs
co-opt
them
for
antiviral
defense.
RNA-Seq
specialized
bioinformatics
have
revealed
the
diversity
virus
infections
induce
TEs.
Furthermore,
studies
with
influenza
uncovered
how
infection-triggered
changes
SUMOylation
TRIM28,
an
epigenetic
co-repressor,
lead
TE
de-repression.
Importantly,
there
growing
appreciation
de-repressed
stimulate
gene
expression,
either
via
cis-acting
enhancer
functions
or
their
recognition
as
viral
mimetics
by
innate
immune
nucleic
acid
sensors
(e.g.
RIG-I,
mda-5
cGAS).
Understanding
viruses
trigger,
counteract,
TE-based
immunity
should
provide
insights
into
pathogenic
mechanisms.
Trends in Genetics,
Год журнала:
2023,
Номер
39(2), С. 109 - 124
Опубликована: Янв. 3, 2023
In
addition
to
the
canonical
right-handed
double
helix,
other
DNA
structures,
termed
'non-B
DNA',
can
form
in
genomes
across
tree
of
life.
Non-B
regulates
multiple
cellular
processes,
including
replication
and
transcription,
yet
its
presence
is
associated
with
elevated
mutagenicity
genome
instability.
These
discordant
roles
fuel
enormous
potential
non-B
drive
genomic
phenotypic
evolution.
Here
we
discuss
recent
studies
establishing
structures
as
novel
functional
elements
subject
natural
selection,
affecting
evolution
transposable
(TEs),
specifying
centromeres.
By
highlighting
contributions
repeated
adaptation
changing
environments,
conclude
that
evolutionary
analyses
should
include
a
perspective
not
only
sequence,
but
also
structure.
Immunological Reviews,
Год журнала:
2025,
Номер
329(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Z‐nucleic
acid
binding
protein
1
(ZBP1)
is
an
innate
immune
sensor
recognizing
nucleic
acids
in
Z‐conformation.
Upon
sensing,
ZBP1
triggers
activation,
inflammation,
and
programmed
cell
death
during
viral
infections,
mice
development,
inflammation‐associated
diseases.
The
Zα
domains
of
sense
promote
RIP‐homotypic
interaction
motif
(RHIM)‐dependent
signaling
complex
assembly
to
mount
inflammation.
studies
on
spurred
understanding
the
role
Z‐form
RNA
DNA
cellular
physiological
functions.
In
particular,
short
genomic
segments,
endogenous
retroviral
elements,
3′UTR
regions
are
likely
sources
Z‐RNAs
that
orchestrate
Recent
seminal
identify
intriguing
association
with
adenosine
deaminase
acting
RNA‐1
(ADAR1),
cyclic
GMP‐AMP
synthase
(cGAS)
regulating
aberrant
chronic
cancer.
Thus,
attractive
target
aid
development
specific
therapeutic
regimes
for
disease
biology.
Here,
we
discuss
Z‐RNA
activation
death,
Also,
how
coordinates
intracellular
perturbations
homeostasis,
formation
regulate
diseases
Chinese Medical Journal,
Год журнала:
2022,
Номер
136(6), С. 653 - 665
Опубликована: Авг. 10, 2022
Abstract
Regulated
cell
death
(RCD),
including
apoptosis,
pyroptosis,
necroptosis,
and
ferroptosis,
is
regulated
by
a
series
of
evolutionarily
conserved
pathways,
required
for
development
tissue
homeostasis.
Based
on
previous
genetic
biochemical
explorations
subroutines,
the
characteristics
each
are
generally
considered
distinctive.
However,
recent
in-depth
studies
noted
presence
crosstalk
between
different
forms
RCD;
hence,
concept
PANoptosis
appeared.
Cancer,
complex
disease,
characterized
stepwise
deregulation
apoptosis
proliferation,
with
significant
morbidity
mortality
globally.
At
present,
RCD
as
well
intricate
relationships
mainly
focus
infectious
diseases,
their
roles
in
cancer
remain
unclear.
As
cancers
dysregulated
inflammatory
responses,
most
current
treatment
strategies
aim
to
selectively
induce
via
pathways
cells.
In
this
review,
we
describe
five
types
detail
respect
tumorigenesis
progression.
The
potential
value
some
these
key
effector
molecules
tumor
diagnosis
therapeutic
response
has
also
been
raised.
We
then
review
highlight
progress
based
ferroptosis
induced
small-molecule
compounds,
immune
checkpoint
inhibitors,
nanoparticles.
Together,
findings
may
provide
meaningful
evidence
fill
gaps
pathogenesis
develop
better
strategies.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(18), С. 10224 - 10224
Опубликована: Сен. 6, 2022
Z-conformation
nucleic
acid
binding
protein
1
(ZBP1),
a
powerful
innate
immune
sensor,
has
been
identified
as
the
important
signaling
initiation
factor
in
response
and
multiple
inflammatory
cell
death
known
PANoptosis.
The
of
ZBP1
requires
recognition
left-handed
double-helix
Z-nucleic
(includes
Z-DNA
Z-RNA)
subsequent
transduction
depends
on
interaction
between
its
adapter
proteins,
such
TANK-binding
kinase
(TBK1),
interferon
regulatory
3
(IRF3),
receptor-interacting
serine/threonine-protein
(RIPK1),
RIPK3.
activated
immunity,
including
type-I
(IFN-I)
NF-κB
signaling,
constitutes
an
line
defense
against
pathogenic
infection.
In
addition,
ZBP1-mediated
PANoptosis
is
double-edged
sword
anti-infection,
auto-inflammatory
diseases,
tumor
immunity.
beneficial
for
eliminating
infected
cells
cells,
but
abnormal
or
excessive
can
lead
to
strong
that
harmful
host.
Thus,
pathogens
host
have
each
developed
multiplex
tactics
targeting
maintain
virulence
homeostasis.
this
paper,
we
reviewed
mechanisms
effects
immunity
pathogen
infection,
various
antagonistic
strategies
ZBP1.
We
also
discuss
existent
gaps
regarding
forecast
potential
directions
future
research.
Proceedings of the National Academy of Sciences,
Год журнала:
2022,
Номер
119(41)
Опубликована: Окт. 3, 2022
The
absence
of
Caspase-8
or
its
adapter,
Fas-associated
death
domain
(FADD),
results
in
activation
receptor
interacting
protein
kinase-3
(RIPK3)-
and
mixed-lineage
kinase-like
(MLKL)-dependent
necroptosis
vivo.
Here,
we
show
that
spontaneous
RIPK3,
phosphorylation
MLKL,
Caspase-8-
FADD-deficient
cells
was
dependent
on
the
nucleic
acid
sensor,
Z-DNA
binding
protein-1
(ZBP1).
We
genetically
engineered
a
mouse
model
by
single
insertion
FLAG
tag
onto
N
terminus
endogenous
MLKL
(
Molecules,
Год журнала:
2023,
Номер
28(2), С. 843 - 843
Опубликована: Янв. 14, 2023
Despite
structural
differences
between
the
right-handed
conformations
of
A-RNA
and
B-DNA,
both
nucleic
acids
adopt
very
similar,
left-handed
Z-conformations.
In
contrast
to
their
similarities
sequence
preferences,
RNA
DNA
exhibit
in
ability
Z-conformation
regarding
hydration
shells,
chemical
modifications
that
promote
Z-conformation,
structure
junctions
connecting
them
segments.
this
review,
we
highlight
properties
Z-DNA
Z-RNA
delve
into
potential
factors
contribute
differences.
While
has
been
extensively
studied,
there
is
a
gap
knowledge
when
it
comes
Z-RNA.
Where
such
information
lacking,
try
extend
principles
stability
formation
Z-RNA,
considering
inherent
acids.
