Liquid biopsy in cancer current: status, challenges and future prospects

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Дек. 1, 2024

Cancer has a high mortality rate across the globe, and tissue biopsy remains gold standard for tumor diagnosis due to its level of laboratory standardization, good consistency results, relatively stable samples, accuracy results. However, there are still many limitations drawbacks in application tumor. The emergence liquid provides new ideas early prognosis Compared with biopsy, advantages treatment various types cancer, including non-invasive, quickly so on. Currently, detection received widely attention. It is now undergoing rapid progress, it holds significant potential future applications. Around now, biopsies encompass several components such as circulating cells, DNA, exosomes, microRNA, RNA, platelets, endothelial cells. In addition, advances identification indicators have significantly enhanced possibility utilizing clinical settings. this review, we will discuss application, challenges some common tumors from perspective diverse systems tumors, look forward development prospects field cancer treatment.

Язык: Английский

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Gastric Cancer - Epidemiology, Modifiable and Non-modifiable Risk Factors, Challenges and Opportunities: An Updated Review

Cancer Treatment and Research Communications, Год журнала: 2024, Номер 41, С. 100845 - 100845

Опубликована: Янв. 1, 2024

Язык: Английский

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Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies

Cell Death and Disease, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 7, 2025

Abstract Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with limited treatment options in advanced stages. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting PD1/PD-L1, has emerged as promising therapeutic approach. However, significant proportion patients exhibit primary or acquired resistance, limiting the overall efficacy immunotherapy. This review provides comprehensive analysis mechanisms underlying immunotherapy resistance GC, including role tumor microenvironment, dynamic PD-L1 expression, compensatory activation other checkpoints, and genomic instability. Furthermore, explores GC-specific factors such molecular subtypes, unique evasion mechanisms, impact Helicobacter pylori infection. We also discuss emerging strategies to overcome combination therapies, novel immunotherapeutic approaches, personalized based on genomics microenvironment. By highlighting these key areas, this aims inform future research directions clinical practice, ultimately improving outcomes for GC undergoing

Язык: Английский

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Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway

APOPTOSIS, Год журнала: 2023, Номер 28(9-10), С. 1390 - 1405

Опубликована: Май 30, 2023

Язык: Английский

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lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Язык: Английский

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A humanized trivalent Nectin-4-targeting nanobody drug conjugate displays potent antitumor activity in gastric cancer

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 16, 2024

Gastric cancer represents a highly lethal malignancy with an elevated mortality rate among patients, coupled suboptimal postoperative survival prognosis. Nectin-4, overexpressed oncological target for various cancers, has been exploited to create antibody-drug conjugates (ADCs) treat solid tumors. However, there is limited research on Nectin-4 ADCs specifically gastric cancer, and conventional immunoglobulin G (IgG)-based frequently encounter binding site barriers. Based the excellent tumor penetration capabilities inherent in nanobodies (Nbs), we developed Nectin-4-targeting Nb drug (NDCs) treatment of cancer.

Язык: Английский

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Downregulation of LncRNA CCAT1 Enhances Chemosensitivity in Cisplatin‐Resistant Gastric Cancer Cells

Drug Development Research, Год журнала: 2025, Номер 86(1)

Опубликована: Янв. 20, 2025

ABSTRACT Chemotherapy is an effective treatment for gastric cancer. However, many patients develop resistance to chemotherapeutic agents during clinical treatment. LncRNA CCAT1 has recently been shown influence cellular specific drugs, but its role in cancer remains underexplored. This study aims investigate the of cisplatin cells and potential underlying mechanisms. Gastric cell lines with acquired were established. The expression was assessed both cisplatin‐sensitive cisplatin‐resistant AGS lines. knocked down AGS/DDP cells, changes IC50 values measured using Cell Counting Kit‐8 (CCK‐8) assay. Apoptosis evaluated by flow cytometry. Additionally, Western blotting employed measure levels PI3K/AKT/mTOR signaling pathway proteins apoptosis‐related interference control groups. RT‐qPCR results indicated that significantly elevated compared non‐resistant cells. Similarly, CCK‐8 assay demonstrated knocking resistant increased their sensitivity Flow cytometry blot further confirmed silencing promoted apoptosis these higher sensitive counterparts, resulted reduced proteins. In conclusion, above studies induced

Язык: Английский

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Photodynamic Therapy in Cancer: Insights into Cellular and Molecular Pathways

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 69 - 69

Опубликована: Янв. 21, 2025

Photodynamic therapy is a non-ionizing radiation treatment that utilizes photosensitizer in combination with light to produce singlet oxygen. This oxygen induces anti-cancer effects by causing apoptotic, necrotic, or autophagic cell death tumor cells. Currently, photodynamic employed oncology treat various cancers. In the presence of oxygen, this non-invasive approach leads direct death, damage microvasculature, and induction local inflammatory response. These allow be effective treating early-stage tumors, extending survival cases where surgery not feasible, significantly improving quality life. paper, we provide state art on cytomolecular mechanisms associated pathways involved therapy. By integrating these mechanistic insights most recent advancements nanotechnology, phototherapeutic has potential become prevalent option within conventional cancer therapies, enhancing its application precision medicine.

Язык: Английский

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Pyroptosis and inflammasomes in cancer and inflammation

MedComm, Год журнала: 2023, Номер 4(5)

Опубликована: Сен. 24, 2023

Abstract Nonprogrammed cell death (NPCD) and programmed (PCD) are two types of death. Cell is significantly linked to tumor development, medication resistance, cancer recurrence, metastatic dissemination. Therefore, a comprehensive understanding essential for the treatment cancer. Pyroptosis kind PCD distinct from autophagy apoptosis in terms structure function cells. The defining features pyroptosis include release an inflammatory cascade reaction expulsion lysosomes, mediators, other cellular substances within cell. Additionally, it displays variations osmotic pressure both outside Pyroptosis, as evidenced by growing body research, critical controlling development diseases In this paper, we reviewed current level knowledge on mechanism inflammasomes their connection diseases. This article presents theoretical framework investigating potential therapeutic targets diseases, overcoming establishing nanomedicines associated with pyroptosis, developing risk prediction models refractory Given link between emergence pyroptosis‐targeted treatments may be cutting‐edge strategy.

Язык: Английский

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Global, Regional, and National Burden of Gastric Cancer in Adolescents and Young Adults, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019

The American Journal of Gastroenterology, Год журнала: 2023, Номер 119(3), С. 454 - 467

Опубликована: Окт. 6, 2023

INTRODUCTION: Gastric cancer is a significant global health concern, ranking as the fifth most common worldwide and third leading cause of cancer-related mortality. While improvements in awareness medical technology have contributed to decline incidence gastric many countries, rate adolescents young adults (GCAYA) has shown an upward trend. Timely effective strategies for screening, detection, treatment are crucial managing burden GCAYA optimizing allocation resources. To this end, our study aimed examine distribution across different factors at global, regional, national levels between 1990 2019. By identifying analyzing these factors, we can better inform efforts combat growing challenge. METHODS: This used data from Global Burden Disease database analyze incidence, mortality, disability-adjusted life years (DALY) The age-standardized (ASIR), mortality rate, DALY (ASDR) were summarized presented visually intuitive manner levels. In addition, calculated estimated annual percentage change each indicator globally, regionally, nationally displayed results. Furthermore, conducted age-based analysis with cancer, comparing age composition deaths patients For sake brevity, will use abbreviation refer among throughout remainder article. RESULTS: From 2019, slightly increased globally. number newly diagnosed cases rose 47,932 (95% uncertainty interval 44,592.9–51,005.7) 49,007 (45,007.7–53,078.1) while decreased 35,270 (32,579–37,678.5) 27,895 (25,710.9–30,240.4). ASIR showed declining trend, decreasing 22.4 21.2–23.6) per 100,000 15.6 (14.1–17.2) also 20.5 (19.2–21.6) 11.9 (10.8–12.8) ASDR 493.4 (463.7–523.7) 268.4 (245.5–290.6) male higher than those female adults. was 2.1 times that individuals (368.9 [328.2–410.3] vs 178.2 [160.5–196.9]), 1.1 (14,971.6 [13,643.3–16,520.5] 12,923.6 [11,550.3–14,339]), (841,920.5 [766,655.5–927,598.8] 731,976.3 [653,421–814,242.8]). regions high-middle middle sociodemographic index countries. 198 countries territories Republic Korea showing greatest decrease 1,360.5 (1,300.3–51,416.5) 298.7 (270.1–328.4) −5.14 confidence −7.23 –2.99). age, highest proportion being 35–39 group. both death mainly concentrated group, accounting approximately half total population. DISCUSSION: past 30 years, although new population growth, overall disease indicates progress diagnosis, treatment, education, efforts. However, remains uneven terms sex, development level, region, country. address challenges, authorities should take appropriate measures such screening programs, strengthening individuals, enhancing prevention control improving infrastructure care resources developing promoting international cooperation, implementing tailored measures.

Язык: Английский

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