Combining immune checkpoint inhibitors with standard treatment regimens in advanced human epidermal growth factor receptor-2 positive gastric cancer patients DOI
Shenghu Zhang, Li Wan,

Xi-Yan Chen

et al.

World Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 17(4)

Published: March 24, 2025

Gastric cancer is one of the most common malignant tumors worldwide, with its incidence and mortality rates ranking among highest in gastrointestinal cancers. The overexpression or gene amplification human epidermal growth factor receptor 2 (HER-2) occurs approximately 15%-20% gastric cancers serves as a critical molecular target influencing prognosis treatment outcomes. For patients HER-2-positive cancer, trastuzumab combined platinum-based chemotherapy has been established standard first-line treatment. However, despite demonstrated clinical benefits prolonging survival, overall efficacy remains limited. In recent years, successful application immune checkpoint inhibitors (ICIs) various tumors, combining ICIs existing regimens emerged promising approach to enhance therapeutic cancer. Nevertheless, prognostic factors remain unclear. To analyze advanced Clinical data from 104 who were treated at our hospital between March 2021 May 2023 retrospectively analyzed. Patients divided into control group (n = 54, regimen) an observation 50, addition regimen). efficacy, survival outcomes, adverse reactions compared two groups. Univariate Cox multivariate analyses performed identify patient prognosis. With median follow-up time 14.6 months, there no significant differences groups terms objective response rate disease (P > 0.05). progression-free (mPFS) mPFS for immunohistochemistry 3 + significantly higher than those < Among group, positive programmed death-ligand 1 (PD-L1) expression had negative PD-L1 Regarding events, observed hypothyroidism neutropenia analysis showed that Eastern Cooperative Oncology Group (ECOG) performance status, peritoneal metastasis, death-1 expression, regimen independent PFS (hazard ratio 1, P demonstrate favorable manageable safety. ECOG are PFS, warranting increased attention exhibiting these factors.

Language: Английский

Liquid biopsy in cancer current: status, challenges and future prospects DOI Creative Commons
Liwei Ma, Huiling Guo, Yunxiang Zhao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 1, 2024

Cancer has a high mortality rate across the globe, and tissue biopsy remains gold standard for tumor diagnosis due to its level of laboratory standardization, good consistency results, relatively stable samples, accuracy results. However, there are still many limitations drawbacks in application tumor. The emergence liquid provides new ideas early prognosis Compared with biopsy, advantages treatment various types cancer, including non-invasive, quickly so on. Currently, detection received widely attention. It is now undergoing rapid progress, it holds significant potential future applications. Around now, biopsies encompass several components such as circulating cells, DNA, exosomes, microRNA, RNA, platelets, endothelial cells. In addition, advances identification indicators have significantly enhanced possibility utilizing clinical settings. this review, we will discuss application, challenges some common tumors from perspective diverse systems tumors, look forward development prospects field cancer treatment.

Language: Английский

Citations

42
Downregulation of LncRNA CCAT1 Enhances Chemosensitivity in Cisplatin‐Resistant Gastric Cancer Cells DOI Open Access
Qiong Wu, Chenglou Zhu, Tiantian Zhao

et al.

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(1)

Published: Jan. 20, 2025

ABSTRACT Chemotherapy is an effective treatment for gastric cancer. However, many patients develop resistance to chemotherapeutic agents during clinical treatment. LncRNA CCAT1 has recently been shown influence cellular specific drugs, but its role in cancer remains underexplored. This study aims investigate the of cisplatin cells and potential underlying mechanisms. Gastric cell lines with acquired were established. The expression was assessed both cisplatin‐sensitive cisplatin‐resistant AGS lines. knocked down AGS/DDP cells, changes IC50 values measured using Cell Counting Kit‐8 (CCK‐8) assay. Apoptosis evaluated by flow cytometry. Additionally, Western blotting employed measure levels PI3K/AKT/mTOR signaling pathway proteins apoptosis‐related interference control groups. RT‐qPCR results indicated that significantly elevated compared non‐resistant cells. Similarly, CCK‐8 assay demonstrated knocking resistant increased their sensitivity Flow cytometry blot further confirmed silencing promoted apoptosis these higher sensitive counterparts, resulted reduced proteins. In conclusion, above studies induced

Language: Английский

Citations

2
Photodynamic Therapy in Cancer: Insights into Cellular and Molecular Pathways DOI Creative Commons

Vincenzo Papa,

Fabiana Furci, Paola Lucia Minciullo

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 69 - 69

Published: Jan. 21, 2025

Photodynamic therapy is a non-ionizing radiation treatment that utilizes photosensitizer in combination with light to produce singlet oxygen. This oxygen induces anti-cancer effects by causing apoptotic, necrotic, or autophagic cell death tumor cells. Currently, photodynamic employed oncology treat various cancers. In the presence of oxygen, this non-invasive approach leads direct death, damage microvasculature, and induction local inflammatory response. These allow be effective treating early-stage tumors, extending survival cases where surgery not feasible, significantly improving quality life. paper, we provide state art on cytomolecular mechanisms associated pathways involved therapy. By integrating these mechanistic insights most recent advancements nanotechnology, phototherapeutic has potential become prevalent option within conventional cancer therapies, enhancing its application precision medicine.

Language: Английский

Citations

2
Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies DOI Creative Commons

D.Y. Luo,

Jing Zhou, Shuiliang Ruan

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 7, 2025

Abstract Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with limited treatment options in advanced stages. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting PD1/PD-L1, has emerged as promising therapeutic approach. However, significant proportion patients exhibit primary or acquired resistance, limiting the overall efficacy immunotherapy. This review provides comprehensive analysis mechanisms underlying immunotherapy resistance GC, including role tumor microenvironment, dynamic PD-L1 expression, compensatory activation other checkpoints, and genomic instability. Furthermore, explores GC-specific factors such molecular subtypes, unique evasion mechanisms, impact Helicobacter pylori infection. We also discuss emerging strategies to overcome combination therapies, novel immunotherapeutic approaches, personalized based on genomics microenvironment. By highlighting these key areas, this aims inform future research directions clinical practice, ultimately improving outcomes for GC undergoing

Language: Английский

Citations

2
Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway DOI
Guang Chen, Huhu Zhang,

Hongxiao Sun

et al.

APOPTOSIS, Journal Year: 2023, Volume and Issue: 28(9-10), P. 1390 - 1405

Published: May 30, 2023

Language: Английский

Citations

24
Gastric Cancer - Epidemiology, Modifiable and Non-modifiable Risk Factors, Challenges and Opportunities: An Updated Review DOI Creative Commons

Tajul Islam Mamun,

Sabrina Younus,

Md Hashibur Rahman

et al.

Cancer Treatment and Research Communications, Journal Year: 2024, Volume and Issue: 41, P. 100845 - 100845

Published: Jan. 1, 2024

Language: Английский

Citations

16
lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ehssan Moglad

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

Citations

11
Pyroptosis and inflammasomes in cancer and inflammation DOI Creative Commons

Jie‐Lin Wang,

Shengni Hua,

Hai‐Juan Bao

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(5)

Published: Sept. 24, 2023

Abstract Nonprogrammed cell death (NPCD) and programmed (PCD) are two types of death. Cell is significantly linked to tumor development, medication resistance, cancer recurrence, metastatic dissemination. Therefore, a comprehensive understanding essential for the treatment cancer. Pyroptosis kind PCD distinct from autophagy apoptosis in terms structure function cells. The defining features pyroptosis include release an inflammatory cascade reaction expulsion lysosomes, mediators, other cellular substances within cell. Additionally, it displays variations osmotic pressure both outside Pyroptosis, as evidenced by growing body research, critical controlling development diseases In this paper, we reviewed current level knowledge on mechanism inflammasomes their connection diseases. This article presents theoretical framework investigating potential therapeutic targets diseases, overcoming establishing nanomedicines associated with pyroptosis, developing risk prediction models refractory Given link between emergence pyroptosis‐targeted treatments may be cutting‐edge strategy.

Language: Английский

Citations

19
PPIH acts as a potential predictive biomarker for patients with common solid tumors DOI Creative Commons
Jun Ye, Jianchao Ying, Hạixia Chen

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 4, 2024

Abstract Background Our previous studies have indicated that mRNA and protein levels of PPIH are significantly upregulated in Hepatocellular Carcinoma (LIHC) could act as predictive biomarkers for patients with LIHC. Nonetheless, the expression implications etiology progression common solid tumors yet to be explored, including its potential a serum tumor marker. Methods We employed bioinformatics analyses, augmented clinical sample evaluations, investigate gene regulation networks various tumors. also assessed association between overall survival (OS) cancer using Kaplan-Meier analysis TCGA database information. Furthermore, we evaluated feasibility diagnostic efficacy marker by integrating serological established markers. Results Through pan-cancer analysis, found multiple were different from those normal tissues. This study is first report markedly elevated LIHC, Colon adenocarcinoma (COAD), Breast (BC), associated worse prognosis these patients. Conversely, decreased (LIHC, COAD, BC, gastric cancer), when combined traditional markers, offer enhanced sensitivity specificity diagnosis. Conclusion findings propose may serve valuable biomarker patients, secreted marker, providing insights into role development progression.

Language: Английский

Citations

8
A humanized trivalent Nectin-4-targeting nanobody drug conjugate displays potent antitumor activity in gastric cancer DOI Creative Commons
Yue Wu,

Min Zhu,

Baihe Sun

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 16, 2024

Gastric cancer represents a highly lethal malignancy with an elevated mortality rate among patients, coupled suboptimal postoperative survival prognosis. Nectin-4, overexpressed oncological target for various cancers, has been exploited to create antibody-drug conjugates (ADCs) treat solid tumors. However, there is limited research on Nectin-4 ADCs specifically gastric cancer, and conventional immunoglobulin G (IgG)-based frequently encounter binding site barriers. Based the excellent tumor penetration capabilities inherent in nanobodies (Nbs), we developed Nectin-4-targeting Nb drug (NDCs) treatment of cancer.

Language: Английский

Citations

7