Pharmaceutics,
Год журнала:
2021,
Номер
13(2), С. 198 - 198
Опубликована: Фев. 2, 2021
Some
issues
in
pharmaceutical
therapies
such
as
instability,
poor
membrane
permeability,
and
bioavailability
of
drugs
can
be
solved
by
the
design
suitable
delivery
systems
based
on
combination
two
pillar
classes
ingredients:
polymers
lipids.
At
same
time,
modern
technologies
are
required
to
overcome
production
limitations
(low
productivity,
high
energy
consumption,
expensive
setup,
long
process
times)
pass
at
industrial
level.
In
this
paper,
a
summary
applications
polymeric
lipid
materials
combined
nanostructures
(hybrid
nanocarriers)
is
reported.
Then,
recent
techniques
adopted
hybrid
nanoparticles
discussed,
highlighting
still
present
that
hold
back
implementation.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(2), С. 487 - 487
Опубликована: Янв. 12, 2020
Chitosan
is
a
product
of
the
deacetylation
chitin,
which
widely
found
in
nature.
insoluble
water
and
most
organic
solvents,
seriously
limits
both
its
application
scope
applicable
fields.
However,
chitosan
contains
active
functional
groups
that
are
liable
to
chemical
reactions;
thus,
derivatives
can
be
obtained
through
modification
chitosan.
The
has
been
an
important
aspect
research,
showing
better
solubility,
pH-sensitive
targeting,
increased
number
delivery
systems,
etc.
This
review
summarizes
by
acylation,
carboxylation,
alkylation,
quaternization
order
improve
pH
sensitivity,
targeting
derivatives.
applications
antibacterial,
sustained
slowly
release,
system
fields
also
described.
will
have
large
impact
show
potential
biomedicine
for
development
drugs
future.
Advanced Drug Delivery Reviews,
Год журнала:
2021,
Номер
171, С. 266 - 288
Опубликована: Фев. 21, 2021
Intercellular
tight
junctions
represent
a
formidable
barrier
against
paracellular
drug
absorption
at
epithelia
(e.g.,
nasal,
intestinal)
and
the
endothelium
blood–brain
barrier).
In
order
to
enhance
transport
of
drugs
increase
their
bioavailability
organ
deposition,
active
excipients
modulating
have
been
applied.
First-generation
permeation
enhancers
(PEs)
acted
by
unspecific
interactions,
while
recently
developed
PEs
address
specific
physiological
mechanisms.
Such
target
junction
modulators
(TJMs)
advantage
defined
mechanism
action.
To
date,
merely
few
these
novel
has
entered
into
clinical
trials,
as
lack
in
safety
efficiency
vivo
often
impedes
commercialisation.
A
stronger
focus
on
development
such
would
result
an
economic
therapeutic
improvement
current
future
drugs.
Biomolecules,
Год журнала:
2022,
Номер
12(5), С. 636 - 636
Опубликована: Апрель 25, 2022
Poly(α-L-glutamic
acid)
(PGA)
is
a
class
of
synthetic
polypeptides
composed
the
monomeric
unit
α-L-glutamic
acid.
Owing
to
their
biocompatibility,
biodegradability,
and
non-immunogenicity,
PGA-based
nanomaterials
have
been
elaborately
designed
for
drug
delivery
systems.
Relevant
studies
including
latest
research
results
on
discussed
in
this
work.
The
following
related
topics
are
summarized
as:
(1)
brief
description
strategies
PGAs;
(2)
an
elaborated
presentation
evolving
applications
PGA
areas
delivery,
rational
design,
precise
fabrication,
biological
evaluation;
(3)
profound
discussion
further
development
delivery.
In
summary,
unique
structures
superior
properties
enables
represent
as
enormous
potential
biomaterials-related
areas.
Abstract
Protein
nanoparticles,
PNPs,
have
played
a
long‐standing
role
in
food
and
industrial
applications.
More
recently,
their
potential
nanomedicine
has
been
more
widely
pursued.
This
review
summarizes
recent
trends
related
to
the
preparation,
application,
chemical
construction
of
nanoparticles
that
use
proteins
as
major
building
blocks.
A
particular
focus
given
emerging
applications
nanomedicine,
an
area
research
where
PNPs
are
poised
for
breakthroughs
drug
delivery
carriers,
particle‐based
therapeutics
or
non‐viral
gene
therapy.
Green Processing and Synthesis,
Год журнала:
2024,
Номер
13(1)
Опубликована: Янв. 1, 2024
Abstract
Materials-based
drug
delivery
approaches
have
garnered
substantial
attention
in
recent
years
due
to
their
potential
revolutionize
pharmaceutical
interventions.
This
abstract
provides
a
concise
overview
of
advancements
and
future
prospects
this
rapidly
evolving
field.
Materials
such
as
nanoparticles,
liposomes,
polymers,
hydrogels
emerged
versatile
carriers
for
delivery.
These
materials
facilitate
precise
control
over
release
kinetics,
enabling
targeted
sustained
therapeutic
effects.
Smart
with
responsiveness
external
stimuli
or
physiological
conditions
further
enhanced
precision.
Personalized
medicine
are
gaining
traction,
tailoring
systems
individual
patient
profiles
needs.
The
horizon
materials-based
is
bright.
Ongoing
research
focused
on
refining
material
design,
streamlining
production
processes,
ensuring
safety
profiles.
Collaborative
efforts
among
researchers,
clinicians,
industry
stakeholders
crucial
translating
these
into
clinical
practice.
Additionally,
the
convergence
diagnostics
imaging
holds
immense
personalized
efficient
healthcare
solutions.
As
continues
evolve,
it
stands
poised
reshape
landscape
pharmaceuticals,
offering
promise
more
effective
patient-centered
therapies
wide
range
medical
conditions.
