Wound Healing: From Passive to Smart Dressings

Advanced Healthcare Materials, Год журнала: 2021, Номер 10(16)

Опубликована: Июнь 26, 2021

Abstract The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden on healthcare systems. Although, application traditional wound dressings contributes to an effective healing outcome, yet, complexity process remains major health challenge. Recent advances materials fabrication technologies have led that provide proper conditions for healing. 3D‐printed dressings, biomolecule‐loaded as well smart flexible bandages are among recent alternatives been developed accelerate Additionally, new generation contains variety microelectronic sensors real‐time monitoring environment is able apply required actions support progress. Moreover, manufacturing enable development next dressing substrates, known electronic skin, whole physiochemical markers single platform. current study reviews importance emerging strategy care management highlights different types promoting process.

Язык: Английский

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Emerging Applications of Nanotechnology in Healthcare and Medicine

Molecules, Год журнала: 2023, Номер 28(18), С. 6624 - 6624

Опубликована: Сен. 14, 2023

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness applications nanotechnology in diagnosis, treatment, and prevention diseases. There also potential uses designing medical tools processes for new generation scientists. The main objective conducting this research review is gather widespread nanomedicine under one heading highlight standard practices field. Comprehensive has been conducted incorporate latest data related medicine therapeutics derived from acknowledged scientific platforms. Nanotechnology used conduct sensitive procedures. showing successful fields diagnostics, disease regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, therapeutics. A thorough association cooperation between physicians, clinicians, researchers, technologies will bring forward a future where there more calculated, outlined, technically programed field nanomedicine. Advances being made overcome challenges associated with application due pathophysiological basis This highlights multipronged how proving health industry. need minimize health, environmental, ethical concerns linked nanotechnology.

Язык: Английский

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Review of Functionalized Nanomaterials for Photothermal Therapy of Cancers

ACS Applied Nano Materials, Год журнала: 2021, Номер 4(11), С. 11353 - 11385

Опубликована: Ноя. 16, 2021

Photothermal therapy (PTT) is recognized as a promising approach for cancer theranostics via the nonradiative conversion of light into heat energy. PTT treatment able to reduce adverse side effects traditional chemotherapy. Some nanomaterials functionalized with unique physical and chemical properties have been integrated multiple imaging modalities therapeutic function applications. In past decade, various applications reviewed, but comprehensive survey all classes photothermal developed in recent years has not done. A discussion mechanisms using different their application combination useful providing insights material development disease future. this review, advancement excellence combined therapies field anticancer are discussed. The momentous property tailored advancing noninvasive also highlighted. Because great deal decades reviewed years, we only include latest results reported 5 comparison.

Язык: Английский

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Plant and Microbial Approaches as Green Methods for the Synthesis of Nanomaterials: Synthesis, Applications, and Future Perspectives

Molecules, Год журнала: 2023, Номер 28(1), С. 463 - 463

Опубликована: Янв. 3, 2023

The unique biological and physicochemical characteristics of biogenic (green-synthesized) nanomaterials (NMs) have attracted significant interest in different fields, with applications the agrochemical, food, medication delivery, cosmetics, cellular imaging, biomedical industries. To synthesize nanomaterials, green synthesis techniques use microorganisms, plant extracts, or proteins as bio-capping bio-reducing agents their role bio-nanofactories for material at nanoscale size. Green chemistry is environmentally benign, biocompatible, nontoxic, economically effective. By taking into account findings from recent investigations, we shed light on most developments using types microbes plants. Additionally, cover green-synthesized food textile industries, water treatment, applications. Furthermore, discuss future perspectives to advance production

Язык: Английский

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Towards principled design of cancer nanomedicine to accelerate clinical translation

Materials Today Bio, Год журнала: 2022, Номер 13, С. 100208 - 100208

Опубликована: Янв. 1, 2022

Nanotechnology in medical applications, especially oncology as drug delivery systems, has recently shown promising results. However, although these advances have been the pre-clinical stages, clinical translation of this technology is challenging. To create systems with increased treatment efficacy for translation, physicochemical characteristics nanoparticles such size, shape, elasticity (flexibility/rigidity), surface chemistry, and charge can be specified to optimize efficiency a given application. Consequently, interdisciplinary researchers focused on producing biocompatible materials, production technologies, or new formulations efficient loading, high stability. The effects design parameters studied

Язык: Английский

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Mesoporous Silica Nanoparticles as a Potential Nanoplatform: Therapeutic Applications and Considerations

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6349 - 6349

Опубликована: Март 28, 2023

With advances in nanotechnology, nanoparticles have come to be regarded as carriers of therapeutic agents and been widely studied overcome various diseases the biomedical field. Among these particles, mesoporous silica (MSNs) investigated potential nanocarriers deliver drug molecules target sites body. This review introduces physicochemical properties MSNs synthesis procedures MSN-based nanoplatforms. Moreover, we focus on updating applications a carrier or diagnostic cargo clinical trials using silica-nanoparticle-based systems. Herein, one hand, pay attention pharmaceutical advantages MSNs, including nanometer particle size, high surface area, porous structures, thus enabling efficient delivery drug-loading content. On other look through biosafety toxicity issues associated with platforms. Based many reports so far, applied construct tissue engineering platforms well treat diseases, cancer, by functionalization incorporation stimuli-responsive components. However, even advantageous aspects that possess, there are still considerations, such optimizing dosage regimens, regarding use clinics. Progress scale-up production thorough investigation into would enable design innovative safe fields.

Язык: Английский

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Simulation-based approaches for drug delivery systems: Navigating advancements, opportunities, and challenges

Journal of Molecular Liquids, Год журнала: 2023, Номер 395, С. 123888 - 123888

Опубликована: Дек. 27, 2023

Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals' targeted and effective administration. However, the intricate interplay between formulations poses challenges their design optimization. Simulations have emerged as indispensable tools for comprehending these interactions enhancing DDS performance to address this complexity. This comprehensive review explores latest advancements simulation techniques provides detailed analysis. The encompasses various methodologies, including molecular dynamics (MD), Monte Carlo (MC), finite element analysis (FEA), computational fluid (CFD), density functional theory (DFT), machine learning (ML), dissipative particle (DPD). These are critically examined context of research. article presents illustrative case studies involving liposomal, polymer-based, nano-particulate, implantable DDSs, demonstrating influential simulations optimizing systems. Furthermore, addresses advantages limitations It also identifies future directions research development, such integrating multiple techniques, refining validating models greater accuracy, overcoming limitations, exploring applications personalized medicine innovative DDSs. employing like MD, MC, FEA, CFD, DFT, ML, DPD offer crucial insights into behaviour, aiding Despite advantages, rapid cost-effective screening, require validation addressing limitations. Future should focus on models, enhance outcomes. paper underscores contribution emphasizing providing valuable facilitating development optimization ultimately patient As we continue explore impact advancing discovery improving DDSs is expected be profound.

Язык: Английский

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Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates

Polymers, Год журнала: 2023, Номер 15(13), С. 2928 - 2928

Опубликована: Июль 1, 2023

The limitations associated with the conventional treatment of cancer have necessitated design and development novel drug delivery systems based mainly on nanotechnology. These include various kinds nanoparticles, such as polymeric solid lipid nanostructured carriers, hydrogels, micelles. Among systems, chitosan-based nanoparticles attracted attention researchers to treat cancer. Chitosan is a polycationic polymer generated from chitin characteristics biocompatibility, biodegradability, non-toxicity, mucoadhesiveness, making it an ideal fabricate systems. However, chitosan poorly soluble in water acidic aqueous solutions. Furthermore, owing presence reactive amino groups, can be chemically modified improve its physiochemical properties. derivatives employed which are used most frequently pharmaceutical sector due their possession nanosize, appropriate pharmacokinetic pharmacodynamic properties, non-immunogenicity, improved stability, loading capacity. capable delivering nucleic acids, chemotherapeutic medicines, bioactives using chitosan. derivative-based targeted specific sites via active passive mechanisms. Based many anticancer drugs now better effectiveness, potency, cytotoxicity, or biocompatibility. tailored derivatives, well use therapy, will examined this review.

Язык: Английский

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Precision-engineered metal and metal-oxide nanoparticles for biomedical imaging and healthcare applications

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 332, С. 103263 - 103263

Опубликована: Июль 31, 2024

The growing field of nanotechnology has witnessed numerous advancements over the past few years, particularly in development engineered nanoparticles. Compared with bulk materials, metal nanoparticles possess more favorable properties, such as increased chemical activity and toxicity, owing to their smaller size larger surface area. Metal exhibit exceptional stability, specificity, sensitivity, effectiveness, making them highly useful biomedical field. are high demand nanotechnology, including Au, Ag, Pt, Cu, Zn, Co, Gd, Eu, Er. These particles excellent physicochemical amenable functionalization, non-corrosiveness, varying optical electronic properties based on shape. can be modified different targeting agents antibodies, liposomes, transferrin, folic acid, carbohydrates. Thus, hold great promise for various applications photoacoustic imaging, magnetic resonance computed tomography (CT), photothermal, photodynamic therapy (PDT). Despite potential, safety considerations, regulatory hurdles must addressed safe clinical applications. This review highlights nanoparticle engineering explores integration emerging technologies bioimaging, cancer therapeutics nanomedicine. By offering valuable insights, this comprehensive offers a deep understanding potential research.

Язык: Английский

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Nanotechnology in healthcare, and its safety and environmental risks

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Язык: Английский

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