Current evidence and therapeutic implication of PANoptosis in cancer DOI Creative Commons
Dickson Kofi Wiredu Ocansey, Fei Qian,

Peipei Cai

и другие.

Theranostics, Год журнала: 2023, Номер 14(2), С. 640 - 661

Опубликована: Дек. 26, 2023

Regulated cell death (RCD) is considered a critical pathway in cancer therapy, contributing to eliminating cells and influencing treatment outcomes. The application of RCD marked by its potential targeted therapy immunotherapy. As type RCD, PANoptosis has emerged as unique form programmed (PCD) characterized features pyroptosis, apoptosis, necroptosis but cannot be fully explained any these pathways alone. It regulated multi-protein complex called the PANoptosome. relatively new concept first described 2019, been shown play role many diseases, including cancer, infection, inflammation. This study reviews PCD particularly emergence implication developing therapeutic strategies for cancer. Studies have that characterization patterns can predict survival response immunotherapy chemotherapy, highlighting used target treatment. also plays limiting spread cells. allows elimination multiple address various challenges treatment, drug resistance immune evasion. Moreover, active investigation mechanisms agents induce likely yield effective treatments improve patient Research on still ongoing, it rapidly evolving field with lead

Язык: Английский

Inflammation and aging: signaling pathways and intervention therapies DOI Creative Commons
Xia Li, Chentao Li, Wanying Zhang

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Июнь 8, 2023

Abstract Aging is characterized by systemic chronic inflammation, which accompanied cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there an urgent need for a systematic organization inflammaging through dimensionality reduction. Factors secreted senescent cells, known as senescence-associated secretory phenotype (SASP), promote inflammation can induce senescence in normal cells. At same time, accelerates immune resulting weakened function inability to clear cells inflammatory factors, creates vicious cycle senescence. Persistently elevated levels organs such bone marrow, liver, lungs cannot be eliminated leading damage aging-related Therefore, has been recognized endogenous factor elimination could potential strategy anti-aging. Here we discuss at molecular, cellular, organ, disease levels, review current aging models, implications cutting-edge single cell technologies, well anti-aging strategies. Since preventing alleviating diseases improving overall quality life are ultimate goals research, our highlights critical features mechanisms along with latest developments future directions providing theoretical foundation novel practical

Язык: Английский

Процитировано

547
Programmed Cell Death Tunes Tumor Immunity DOI Creative Commons
Jing Liu,

Minjing Hong,

Yijia Li

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Март 30, 2022

The demise of cells in various ways enables the body to clear unwanted cells. Studies over years revealed distinctive molecular mechanisms and functional consequences several key cell death pathways. Currently, most intensively investigated programmed (PCD) includes apoptosis, necroptosis, pyroptosis, ferroptosis, PANoptosis, autophagy, which has been discovered play crucial roles modulating immunosuppressive tumor microenvironment (TME) determining clinical outcomes cancer therapeutic approaches. PCD can dual roles, either pro-tumor or anti-tumor, partly depending on intracellular contents released during process. also regulates enrichment effector regulatory immune cells, thus participating fine-tuning anti-tumor immunity TME. In this review, we focused primarily discussed messengers regulating their intricate crosstalk with response TME, explored immunological consequence its implications future therapy developments.

Язык: Английский

Процитировано

232
STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS) DOI Creative Commons

Yasmine Messaoud‐Nacer,

Elodie Culerier,

Stéphanie Rose

и другие.

Cell Death and Disease, Год журнала: 2022, Номер 13(3)

Опубликована: Март 25, 2022

Abstract Stimulator of interferon genes (STING) contributes to immune responses against tumors and may control viral infection including SARS-CoV-2 infection. However, activation the STING pathway by airway silica or smoke exposure leads cell death, self-dsDNA release, STING/type I IFN dependent acute lung inflammation/ARDS. The inflammatory response induced a synthetic non-nucleotide-based diABZI agonist, in comparison natural cyclic dinucleotide cGAMP, is unknown. A low dose (1 µg endotracheal route for 3 consecutive days) triggered an neutrophilic inflammation, disruption respiratory barrier, DNA release with NET formation, PANoptosis cytokines type inflammation. Downstream upregulation sensors cGAS, DDX41, IFI204, as well NLRP3 AIM2 inflammasomes, suggested secondary dsDNA danger signal. DNase treatment, inhibition formation together investigation gene-deficient mice highlighted extracellular TLR9, but not central diABZI-induced response. Therefore, death lead ARDS which be modeled diABZI. These results show that targeting activator therapeutic strategy enhance inflammation severe ARDS.

Язык: Английский

Процитировано

160
PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality DOI Open Access
Pandian Nagakannan, Thirumala‐Devi Kanneganti

The Journal of Immunology, Год журнала: 2022, Номер 209(9), С. 1625 - 1633

Опубликована: Окт. 20, 2022

Abstract Innate immunity is the first response to protect against pathogens and cellular insults. Pattern recognition receptors sense pathogen- damage-associated molecular patterns induce an innate immune characterized by inflammation programmed cell death (PCD). In-depth characterization of PCD pathways has highlighted significant cross-talk. Recent advances led identification a unique inflammatory modality called PANoptosis, which regulated multifaceted PANoptosome complexes that are assembled integrating components from other pathways. The totality biological effects observed in PANoptosis cannot be accounted for any pathway alone. In this review, we briefly describe mechanisms death, including activation regulation. We also highlight PANoptosomes identified date provide overview implications disease therapeutic targeting. Improved understanding immune-mediated critical inform next generation treatment strategies.

Язык: Английский

Процитировано

144
Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment DOI Creative Commons
Peng Zhu,

Zhuo-Ran Ke,

Jing-Xian Chen

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 9, 2023

PANoptosis, a new research hotspot at the moment, is cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur same population. In essence, PANoptosis highly coordinated dynamically balanced programmed inflammatory pathway that combines main features of necroptosis. Many variables, such as infection, injury, or self-defect, may be involved occurrence with assembly activation PANoptosome being most critical. has been linked to development multiple systemic diseases human body, including infectious diseases, cancer, neurodegenerative diseases. Therefore, it necessary clarify process occurrence, regulatory mechanism its relation this paper, we summarized differences relations between three types death, emphatically expounded molecular patterns expectation facilitating application regulation disease treatment.

Язык: Английский

Процитировано

108
Cell death regulation: A new way for natural products to treat osteoporosis DOI Creative Commons
Zhichao Li, Dandan Li, Renchang Chen

и другие.

Pharmacological Research, Год журнала: 2022, Номер 187, С. 106635 - 106635

Опубликована: Дек. 26, 2022

Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within bone. Intra-bone dependent on precise dynamic balance between resorption by osteoclasts and formation mesenchymal lineage osteoblasts, which comprises series complex highly standardized steps. Programmed cell death (PCD) (e.g., apoptosis, autophagy, ferroptosis, pyroptosis, necroptosis) process involves cascade gene expression events with tight structures. These play certain role in regulating metabolism determining fate cells. Moreover, existing research has suggested natural products derived wide variety dietary components medicinal plants modulate PCDs based different mechanisms, show great potential for prevention treatment osteoporosis, thus revealing emergence more acceptable complementary alternative drugs lower costs, fewer side effects long-term application. Accordingly, this review summarizes types field osteoporosis. perspective targeting PCDs, also discussed roles currently reported osteoporosis involved mechanisms. Based this, provides insights into new molecular mechanisms reference developing anti-osteoporosis future.

Язык: Английский

Процитировано

105
Pyroptosis and pyroptosis-inducing cancer drugs DOI Open Access
Fan Yang, Sahana Bettadapura, Mark S. Smeltzer

и другие.

Acta Pharmacologica Sinica, Год журнала: 2022, Номер 43(10), С. 2462 - 2473

Опубликована: Март 14, 2022

Язык: Английский

Процитировано

91
PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis DOI Creative Commons
Chunxia Shi, Pan Cao, Yukun Wang

и другие.

Journal of Inflammation Research, Год журнала: 2023, Номер Volume 16, С. 1523 - 1532

Опубликована: Апрель 1, 2023

Abstract: PANoptosis is a new cell death proposed by Malireddi et al in 2019, which characterized pyroptosis, apoptosis and necroptosis, but cannot be explained any of them alone. The interaction between necroptosis involved PANoptosis. In this review, from the perspective PANoptosis, we focus on relationship key molecules process formation PANoptosome, as well role diseases. We aim to understand mechanism provide basis for targeted intervention PANoptosis-related treat human Keywords: apoptosis,

Язык: Английский

Процитировано

83
FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM DOI Creative Commons
Yaguang Bi, Haixia Xu, Xiang Wang

и другие.

Cell Death and Disease, Год журнала: 2022, Номер 13(12)

Опубликована: Дек. 5, 2022

Abstract Doxorubicin (DOX) is an effective anthracycline chemotherapeutic anticancer drug with its life-threatening cardiotoxicity severely limiting clinical application. Mitochondrial damage-induced cardiomyocyte death considered essential cue for DOX cardiotoxicity. FUN14 domain containing 1 (FUNDC1) a mitochondrial membrane protein participating in the regulation of integrity multiple diseases although role cardiomyopathy remains elusive. Here, we examined whether PANoptosis, novel type programmed cell closely associated damage, was involved DOX-induced heart injury, and FUNDC1-mediated if any. FUNDC1 downregulated tissues patients dilated (DCM) DOX-challenged mice. deficiency aggravated cardiac dysfunction, PANoptosis. Further examination revealed that countered cytoplasmic release DNA (mtDNA) activation PANoptosome through interaction Tu translation elongation factor (TUFM), key translational expression repair DNA, via 96–133 amino acid domain. TUFM intervention reversed FUNDC1-elicited protection against mtDNA cytosolic Our findings shed light toward beneficial thus offering therapeutic promises

Язык: Английский

Процитировано

77
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma DOI Creative Commons
Zhou Zeng,

Mengling You,

Cong Fan

и другие.

Redox Biology, Год журнала: 2023, Номер 62, С. 102687 - 102687

Опубликована: Март 21, 2023

Glaucoma is a common neurodegenerative disease characterized by progressive retinal ganglion cell (RGC) loss and visual field defects. Pathologically high intraocular pressure (ph-IOP) an important risk factor for glaucoma, it triggers molecularly distinct cascades that control RGC death axonal degeneration. Dynamin-related protein 1 (Drp1)-mediated abnormalities in mitochondrial dynamics are involved glaucoma pathogenesis; however, little known about the precise pathways regulate injury death. Here, we aimed to investigate role of ERK1/2-Drp1-reactive oxygen species (ROS) axis relationship between Drp1-mediated PANoptosis ph-IOP injury. Our results suggest inhibiting ERK1/2-Drp1-ROS pathway potential therapeutic strategy treating ph-IOP-induced injuries. Furthermore, Drp1 can modulating caspase3-dependent, nucleotide-binding oligomerization domain-like receptor-containing pyrin domain 3(NLRP3)-dependent, receptor-interacting (RIP)-dependent model. Overall, our findings provide new insights into possible protective interventions could improve survival.

Язык: Английский

Процитировано

70