Biochemical Pharmacology, Год журнала: 2025, Номер 233, С. 116752 - 116752
Опубликована: Янв. 10, 2025
Язык: Английский
Advanced Science, Год журнала: 2023, Номер 10(26)
Опубликована: Июль 12, 2023
In recent years, the incidence of gastrointestinal cancers is increasing, particularly in younger population. Effective treatment crucial for improving patients' survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role growth and development organisms. It also critical maintaining tissue organ homeostasis takes part multiple pathological processes. addition to apoptosis, there are other types programmed such as ferroptosis, necroptosis, pyroptosis, which can induce severe inflammatory responses. Notably, besides pyroptosis contribute occurrence cancers. This review aims provide comprehensive summary on biological roles molecular mechanisms well their regulators hope open up new paths tumor targeted therapy near future.
Язык: Английский
Процитировано
44
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116112 - 116112
Опубликована: Янв. 2, 2024
Ferroptosis is a newly identified form of non-apoptotic programmed cell death, characterized by the iron-dependent accumulation lethal lipid reactive oxygen species (ROS) and peroxidation membrane polyunsaturated fatty acid phospholipids (PUFA-PLs). unique among other death modalities in many aspects. It initiated excessive oxidative damage due to iron overload compromised antioxidant defense systems, including system Xc-/ glutathione (GSH)/glutathione peroxidase 4 (GPX4) pathway GPX4-independent pathways. In past ten years, ferroptosis was reported play critical role pathogenesis various cardiovascular diseases, e.g., atherosclerosis (AS), arrhythmia, heart failure, diabetic cardiomyopathy, myocardial ischemia-reperfusion injury. Studies have dysfunctional metabolism abnormal expression profiles ferroptosis-related factors, iron, GSH, GPX4, ferroportin (FPN), SLC7A11 (xCT), as indicators for atherogenesis. Moreover, plaque cells, i.e., vascular endothelial (VEC), macrophage, smooth muscle (VSMC), positively correlate with atherosclerotic development. Many macromolecules, drugs, Chinese herbs, food extracts can inhibit atherogenic process suppressing cells. contrast, some inducers significant pro-atherogenic effects. However, mechanisms through which affects progression AS still need be well-known. This review summarizes molecular their emerging AS, aimed at providing novel, promising druggable targets anti-AS therapy.
Язык: Английский
Процитировано
35
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 21, 2024
Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.
Язык: Английский
Процитировано
34
Bone Research, Год журнала: 2024, Номер 12(1)
Опубликована: Фев. 18, 2024
Osteoporosis, a metabolic bone disease characterized by low mineral density and deterioration of microarchitecture, has led to high risk fatal osteoporotic fractures worldwide. Accumulating evidence revealed that sexual dimorphism is notable feature osteoporosis, with sex-specific differences in epidemiology pathogenesis. Specifically, females are more susceptible than males while prone disability or death from the disease. To date, sex chromosome abnormalities steroid hormones have been proven contribute greatly osteoporosis regulating functions cells. Understanding its related complications essential for improving treatment strategies tailored women men. This literature review focuses on mechanisms underlying mainly population aging patients, chronic glucocorticoid administration, diabetes. Moreover, we highlight implications developing therapeutics preventive screening approaches Additionally, challenges translating bench research bedside treatments future directions overcome these obstacles will be discussed.
Язык: Английский
Процитировано
27
Phytomedicine, Год журнала: 2024, Номер 128, С. 155516 - 155516
Опубликована: Март 16, 2024
Recently, osteoblast pyroptosis has been proposed as a potential pathogenic mechanism underlying osteoporosis, although this remains to be confirmed. Luteolin (Lut), flavonoid phytochemical, plays critical role in the anti-osteoporosis effects of many traditional Chinese medicine prescriptions. However, its protective impact on osteoblasts postmenopausal osteoporosis (PMOP) not elucidated. This research aimed determine effect Lut ameliorating PMOP by alleviating and sustaining osteogenesis. was designed investigate novel both cell animal models. Ovariectomy-induced models were established mice with/without daily gavaged 10 or 20 mg/kg body weight Lut. The bone microstructure, metabolism oxidative stress evaluated with 0.104 Estradiol Valerate Tablets positive control. Network pharmacological analysis molecular docking employed mechanisms treatment. Subsequently, impacts PI3K/AKT axis, stress, mitochondria, assessed. In vitro, cultured (MC3T3-E1(14) cells exposed H2O2 examine signaling pathway, osteogenic differentiation, mitochondrial function, pyroptosis. Our findings demonstrated that Lut, similar control drug, effectively reduced systemic loss enhanced induced ovariectomy. indicated axis target, response nuclear membrane function being key mechanisms. Consequently, investigated. vivo data revealed deactivated following ovariectomy, restored phosphorylation proteins, thereby reactivating axis. Additionally, alleviated abnormalities intervention mitigated inhibition osteogenesis, well H2O2-induced Furthermore, attenuated ROS accumulation dysfunction. including osteogenesis restoration, anti-pyroptosis, maintenance, all reversed LY294002 (a pathway inhibitor). summary, could improve dysfunction, alleviate GSDME-mediated maintain via activating PI3K/Akt offering new therapeutic strategy for PMOP.
Язык: Английский
Процитировано
20
Advanced Materials, Год журнала: 2023, Номер 36(13)
Опубликована: Дек. 16, 2023
Abstract Osteoporosis, characterized by an imbalance in bone homeostasis, is a global health concern. Bone defects are difficult to heal patients with osteoporosis. Classical drug treatments for osteoporotic have unsatisfactory efficacy owing side effects and imprecise delivery problems. In this study, magnetic aggregation‐induced bone‐targeting poly(lactic‐co‐glycolic acid, PLGA)‐based nanocarrier (ZOL‐PLGA@Yoda1/SPIO) synthesized realize dual‐targeted precise Piezo1‐activated therapy defects. Piezo1 important mechanotransducer that plays key role regulating homeostasis. To achieve dual‐targeting properties, ZOL‐PLGA@Yoda1/SPIO fabricated using zoledronate (ZOL)‐decorated PLGA, superparamagnetic iron oxide (SPIO), molecule Yoda1 via the emulsion solvent diffusion method. Bone‐targeting molecular mediation properties can jointly effectively localized Moreover, loading enables targeted efficient mimicking of mechanical signals activation Piezo1. Experiments vivo vitro demonstrate activate defect areas mice, improve osteogenesis through YAP/β‐catenin signaling axis, promote well‐coordinated osteogenesis–angiogenesis coupling, significantly accelerate reconstruction within without noticeable effects. Overall, novel provides potentially effective strategy clinical treatment
Язык: Английский
Процитировано
36
Molecules, Год журнала: 2023, Номер 28(20), С. 7173 - 7173
Опубликована: Окт. 19, 2023
Epimedium is a classical Chinese herbal medicine, which has been used extensively to treat various diseases, such as sexual dysfunction, osteoporosis, cancer, rheumatoid arthritis, and brain diseases. Flavonoids, icariin, baohuoside I, icaritin, epimedin C, are the main active ingredients with diverse pharmacological activities. Currently, most flavonoids extracted from plants, but this method cannot meet increasing market demand. Biotransformation strategies promised huge potential for contents of high-value flavonoids, would promote full use herb. Complete biosynthesis major by microbial cell factories enable industrial-scale production flavonoids. This review summarizes structures, activities, pathways in plant, well extraction methods advancements biotransformation complete synthesis provide valuable insights future studies on herb usage
Язык: Английский
Процитировано
27
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Июнь 6, 2023
Background: Triple-negative breast cancer (TNBC) is one of the most prominent neoplasm disorders and lacks efficacious treatments yet. Luteolin (3',4',5,7-tetrahydroxyflavone), a natural flavonoid commonly presented in plants, has been reported to delay progression TNBC. However, precise mechanism still elusive. We aimed elucidate inhibition molecular regulation luteolin on Methods: The effects biological functions TNBC cells were first evaluated using corresponding assays for cell counting kit-8 assay, flow cytometry, wound-healing transwell migration respectively. was then analyzed by RNA sequencing verified RT-qPCR, Western blot, transmission electron microscopy, etc. Finally, vivo mouse tumor models constructed further confirm TNBC.Results: dramatically suppressed proliferation, invasion, while favoring apoptosis dose- time-dependent manner. In treated with luteolin, SGK1 AKT3 significantly downregulated their downstream gene BNIP3 upregulated. According results 3D modeling, direct binding superior that AKT3. promoted FOXO3a translocation into nucleus led transcription both vitro vivo, eventually facilitating interaction between autophagy protein. Furthermore, upregulation SGK1, induced attenuated Conclusion: inhibits inducing through SGK1-FOXO3a-BNIP3 signaling.
Язык: Английский
Процитировано
22
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116777 - 116777
Опубликована: Май 24, 2024
Neuroimmune and neurodegenerative ailments impose a substantial societal burden. disorders involve the intricate regulatory interactions between immune system central nervous system. Prominent examples of neuroimmune encompass multiple sclerosis neuromyelitis optica. Neurodegenerative diseases result from neuronal degeneration or demyelination in brain spinal cord, such as Alzheimer's disease, Parkinson's Huntington's amyotrophic lateral sclerosis. The precise underlying pathogenesis these conditions remains incompletely understood. Ferroptosis, programmed form cell death characterised by lipid peroxidation iron overload, plays pivotal role diseases. In this review, we provide detailed overview ferroptosis, its mechanisms, pathways, regulation during progression Furthermore, summarise impact ferroptosis on neuroimmune-related cells (T cells, B neutrophils, macrophages) neural (glial neurons). Finally, explore potential therapeutic implications inhibitors diverse
Язык: Английский
Процитировано
11
Advanced Functional Materials, Год журнала: 2024, Номер 34(32)
Опубликована: Май 6, 2024
Abstract Efforts to develop advanced bone substitutes for effective regeneration in substantial defects have led the fabrication of tissue‐engineered scaffolds. These scaffolds, featuring hierarchical structures, specific chemical compositions, and functional qualities, are essential mimicking native tissue. Inspired by biomineralization process, hydrothermal treatment is used synthesize micro‐/nano‐hydroxyapatite bioceramics functionalized with tea polyphenols (TP‐nwHA), closely resembling structure bone‐like apatite induced hydroxyapatite vivo. The vitro results demonstrate TP‐nwHA's superior biocompatibility, enhancing cell proliferation adhesion. Furthermore, TP‐nwHA scaffolds significantly influence mesenchymal stem cells, promoting osteogenic differentiation while inhibiting osteoclastogenic differentiation. upregulation proteins BMP2 ITGB1, along downregulation osteoclastic FGF21 IGFBP1, synergistic effect biomimetic on activation MAPK signaling pathway. In vivo, showe early angiogenic capabilities, leading improved critical‐size femoral osteoporotic rats. Histological staining confirms complete bridging new tissue group, nanoindentation tests indicate formation mature mineralized Collectively, these findings suggest a novel strategy fabricating bone‐mimicking constructs potential applications disease modeling.
Язык: Английский
Процитировано
9