Current evidence and therapeutic implication of PANoptosis in cancer DOI Creative Commons
Dickson Kofi Wiredu Ocansey, Fei Qian,

Peipei Cai

и другие.

Theranostics, Год журнала: 2023, Номер 14(2), С. 640 - 661

Опубликована: Дек. 26, 2023

Regulated cell death (RCD) is considered a critical pathway in cancer therapy, contributing to eliminating cells and influencing treatment outcomes. The application of RCD marked by its potential targeted therapy immunotherapy. As type RCD, PANoptosis has emerged as unique form programmed (PCD) characterized features pyroptosis, apoptosis, necroptosis but cannot be fully explained any these pathways alone. It regulated multi-protein complex called the PANoptosome. relatively new concept first described 2019, been shown play role many diseases, including cancer, infection, inflammation. This study reviews PCD particularly emergence implication developing therapeutic strategies for cancer. Studies have that characterization patterns can predict survival response immunotherapy chemotherapy, highlighting used target treatment. also plays limiting spread cells. allows elimination multiple address various challenges treatment, drug resistance immune evasion. Moreover, active investigation mechanisms agents induce likely yield effective treatments improve patient Research on still ongoing, it rapidly evolving field with lead

Язык: Английский

Mitochondrial dysfunctions induce PANoptosis and ferroptosis in cerebral ischemia/reperfusion injury: from pathology to therapeutic potential DOI Creative Commons
Ruining She,

Danhong Liu,

Jun Liao

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Май 24, 2023

Ischemic stroke (IS) accounts for more than 80% of the total stroke, which represents leading cause mortality and disability worldwide. Cerebral ischemia/reperfusion injury (CI/RI) is a cascade pathophysiological events following restoration blood flow reoxygenation, not only directly damages brain tissue, but also enhances series pathological signaling cascades, contributing to inflammation, further aggravate damage tissue. Paradoxically, there are still no effective methods prevent CI/RI, since detailed underlying mechanisms remain vague. Mitochondrial dysfunctions, characterized by mitochondrial oxidative stress, Ca 2+ overload, iron dyshomeostasis, DNA (mtDNA) defects quality control (MQC) disruption, closely relevant process CI/RI. There increasing evidence that dysfunctions play vital roles in regulation programmed cell deaths (PCDs) such as ferroptosis PANoptosis, newly proposed conception unique form innate immune inflammatory death regulated multifaceted PANoptosome complexes. In present review, we highlight how this key event contributes response well modes during Neuroprotective agents targeting may serve promising treatment strategy alleviate serious secondary injuries. A comprehensive insight into dysfunctions-mediated PCDs can help provide strategies guide therapies CI/RI IS.

Язык: Английский

Процитировано

62
Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis DOI Creative Commons

Ein Lee,

Chang‐Hyun Song, Sung‐Jin Bae

и другие.

Experimental & Molecular Medicine, Год журнала: 2023, Номер 55(8), С. 1632 - 1643

Опубликована: Авг. 23, 2023

Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied regulated cell death (RCD) pathways, contribute to clearance of infected or potentially neoplastic cells, highlighting their importance in homeostasis, host defense against pathogens, cancer, a wide range other pathologies. Although these four RCD pathways employ distinct molecular cellular processes, emerging genetic biochemical studies have suggested remarkable flexibility crosstalk among them. The pyroptosis, apoptosis necroptosis is more evident responses infection, has led conceptualization PANoptosis. In this review, we provide brief overview mechanisms ferroptosis maintaining homeostasis. We discuss intricate current evidence supporting PANoptosis, focusing on infectious diseases cancer. Understanding fundamental processes various crucial inform development new therapeutics many diseases, including sterile inflammation,

Язык: Английский

Процитировано

51
NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress DOI Creative Commons
Joo‐Hui Han, Rajendra Karki, R. K. Subbarao Malireddi

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 26, 2024

Innate immunity provides the first line of defense through multiple mechanisms, including pyrogen production and cell death. While elevated body temperature during infection is beneficial to clear pathogens, heat stress (HS) can lead inflammation pathology. Links between pathogen exposure, HS, cytokine release, have been observed, but fundamental innate immune mechanisms driving pathology exposure HS remain unclear. Here, we use genetic approaches elucidate pathways in or LPS models. Our results show that bacteria robustly increase inflammatory death dependent on caspase-1, caspase-11, caspase-8, RIPK3 PANoptosis pathway. Caspase-7 also contributes this context. Furthermore, NINJ1 an important executioner release molecules, independent other pore-forming proteins, gasdermin D, E, MLKL. In vivo model, mortality reduced by deleting fully rescued key molecules. findings suggest therapeutic strategies blocking its upstream regulators prevent may reduce mediators benefit patients.

Язык: Английский

Процитировано

27
PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field DOI Open Access
Lam Nhat Nguyen, Thirumala‐Devi Kanneganti

Journal of Molecular Biology, Год журнала: 2021, Номер 434(4), С. 167249 - 167249

Опубликована: Сен. 16, 2021

Язык: Английский

Процитировано

72
It’s All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects DOI Creative Commons
Jessica M. Gullett, Rebecca E. Tweedell, Thirumala‐Devi Kanneganti

и другие.

Cells, Год журнала: 2022, Номер 11(9), С. 1495 - 1495

Опубликована: Апрель 29, 2022

The innate immune system provides the first line of defense against cellular perturbations. Innate activation elicits inflammatory programmed cell death in response to microbial infections or alterations homeostasis. Among most well-characterized pathways are pyroptosis, apoptosis, and necroptosis. While these have historically been defined as segregated independent processes, mounting evidence shows significant crosstalk among them. These molecular interactions described 'crosstalk', 'plasticity', 'redundancies', 'molecular switches', more. Here, we discuss key components note several examples crosstalk. We then explain how diverse descriptions throughout literature can be interpreted through lens an integrated concept, PANoptosis. totality biological effects PANoptosis cannot individually accounted for by necroptosis alone. also PANoptosomes, which multifaceted macromolecular complexes that regulate consider PANoptosis, has mechanistically characterized during influenza A virus, herpes simplex virus 1, Francisella novicida, Yersinia infections, well altered homeostasis, diseases, cancers. further role IRF1 upstream regulator conclude reexamining historical studies lend credence concept. Cell shown play a critical neurodegenerative cancers, more; therefore, having holistic understanding is important identifying new therapeutic strategies.

Язык: Английский

Процитировано

71
Pharmacological activities and pharmacokinetics of liquiritin: A review DOI

Junyuan Qin,

Junren Chen, Peng Fu

и другие.

Journal of Ethnopharmacology, Год журнала: 2022, Номер 293, С. 115257 - 115257

Опубликована: Апрель 5, 2022

Язык: Английский

Процитировано

70
Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer DOI Creative Commons
Chunmei Zhang, Ning Liu

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июль 25, 2022

Ovarian cancer (OC) is one of the most common malignancies that causes death in women and a heterogeneous disease with complex molecular genetic changes. Because relatively high recurrence rate OC, it crucial to understand associated mechanisms drug resistance discover potential target for rational targeted therapy. Cell genetically determined process. Active orderly cell prevalent during development living organisms plays critical role regulating life homeostasis. Ferroptosis, novel type discovered recent years, distinct from apoptosis necrosis mainly caused by imbalance between production degradation intracellular lipid reactive oxygen species triggered increased iron content. Necroptosis regulated non-cysteine protease–dependent programmed necrosis, morphologically exhibiting same features as occurring via unique mechanism different apoptotic signaling pathway. Pyroptosis form characterized formation membrane pores subsequent lysis well release pro-inflammatory contents mediated abscisin family. Studies have shown ferroptosis, necroptosis, pyroptosis are involved progression variety diseases, including tumors. In this review, we summarized advances occurrence, development, therapeutic OC.

Язык: Английский

Процитировано

58
Regulated cell death in cancer: from pathogenesis to treatment DOI Creative Commons
Linjing Gong, Dong Huang,

Yujun Shi

и другие.

Chinese Medical Journal, Год журнала: 2022, Номер 136(6), С. 653 - 665

Опубликована: Авг. 10, 2022

Abstract Regulated cell death (RCD), including apoptosis, pyroptosis, necroptosis, and ferroptosis, is regulated by a series of evolutionarily conserved pathways, required for development tissue homeostasis. Based on previous genetic biochemical explorations subroutines, the characteristics each are generally considered distinctive. However, recent in-depth studies noted presence crosstalk between different forms RCD; hence, concept PANoptosis appeared. Cancer, complex disease, characterized stepwise deregulation apoptosis proliferation, with significant morbidity mortality globally. At present, RCD as well intricate relationships mainly focus infectious diseases, their roles in cancer remain unclear. As cancers dysregulated inflammatory responses, most current treatment strategies aim to selectively induce via pathways cells. In this review, we describe five types detail respect tumorigenesis progression. The potential value some these key effector molecules tumor diagnosis therapeutic response has also been raised. We then review highlight progress based ferroptosis induced small-molecule compounds, immune checkpoint inhibitors, nanoparticles. Together, findings may provide meaningful evidence fill gaps pathogenesis develop better strategies.

Язык: Английский

Процитировано

58
Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection DOI

Annuurun Nisa,

Franciele Kipper,

Dipak Panigrahy

и другие.

AJP Cell Physiology, Год журнала: 2022, Номер 323(5), С. C1444 - C1474

Опубликована: Окт. 3, 2022

Mycobacterium tuberculosis ( Mtb) is the pathogen that causes (TB), a leading infectious disease of humans worldwide. One main histopathological hallmarks TB formation granulomas comprised elaborately organized aggregates immune cells containing pathogen. Dissemination Mtb from infected in due to host and mycobacterial factors induces multiple cell death modalities cells. Based on molecular mechanism, morphological characteristics, signal dependency, there are two categories death: programmed nonprogrammed. Programmed (PCD), such as apoptosis autophagy, associated with protective response by keeping bacteria encased within dead macrophages can be readily phagocytosed arriving uninfected or neighboring In contrast, non-PCD necrotic favors pathogen, resulting bacterial release into extracellular environment. Multiple types PCD category, including pyroptosis, necroptosis, ferroptosis, ETosis, parthanatos, PANoptosis, may involved infection. Since pathways essential for immunity Mtb, therapeutic compounds targeting signaling have been experimentally tested treatment. This review summarizes different Mtb-mediated deaths, mechanisms underpinning during infection, its potential implications immunity. addition, preventive approaches against infection also discussed.

Язык: Английский

Процитировано

58
GSDME Is Related to Prognosis and Response to Chemotherapy in Oral Cancer DOI
Shuo Wang,

Master Jingwen Zhang,

Zhi‐Zhong Wu

и другие.

Journal of Dental Research, Год журнала: 2022, Номер 101(7), С. 848 - 858

Опубликована: Фев. 11, 2022

Gasdermin E (GSDME), as the major executive protein of pyroptosis, has been considered to be linked antitumor immunity in recent years. However, role GSDME oral squamous cell carcinoma (OSCC) remains elucidated. Here, by using a human OSCC tissue microarray, tissue, and Tgfbr1/ Pten conditional knockout mice, we found that was strongly expressed expression primary tumors higher than metastatic lymph nodes. In addition, positively related better prognosis. Moreover, GSDME-mediated pyroptosis occurred upon stimulation with chemotherapy drugs, functional knockdown attenuated cisplatin-induced effect. Consistent these results, bioinformatic analysis indicated correlated sensitivity number drugs approved US Food Drug Administration. Inhibition small interfering RNA SCC7 cells significantly increased cancer stem markers, CD44 ALDH1. Furthermore, multiplexed immunohistochemistry flow cytometry tumor-infiltrating CD8 + T cells, granzyme B, M1 phenotype macrophages. Collectively, findings demonstrated is potential positive prognostic factor OSCC, induced plays response.

Язык: Английский

Процитировано

51