Epigenetic regulation in adult neural stem cells
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Янв. 31, 2024
Neural
stem
cells
(NSCs)
exhibit
self-renewing
and
multipotential
properties.
Adult
NSCs
are
located
in
two
neurogenic
regions
of
adult
brain:
the
ventricular-subventricular
zone
(V-SVZ)
lateral
ventricle
subgranular
dentate
gyrus
hippocampus.
Maintenance
differentiation
regulated
by
both
intrinsic
extrinsic
signals
that
may
be
integrated
through
expression
some
key
factors
NSCs.
A
number
transcription
have
been
shown
to
play
essential
roles
transcriptional
regulation
NSC
cell
fate
transitions
brain.
Epigenetic
regulators
also
emerged
as
players
NSCs,
neural
progenitor
their
differentiated
progeny
via
epigenetic
modifications
including
DNA
methylation,
histone
modifications,
chromatin
remodeling
RNA-mediated
regulation.
This
minireview
is
primarily
focused
on
regulations
during
neurogenesis,
conjunction
with
these
processes.
Язык: Английский
Altered hippocampal neurogenesis in a mouse model of autism revealed by genetic polymorphisms and by atypical development of newborn neurons
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 26, 2024
Individuals
with
autism
spectrum
disorder
(ASD)
often
exhibit
atypical
hippocampal
anatomy
and
connectivity
throughout
their
lifespan,
potentially
linked
to
alterations
in
the
neurogenic
process
within
hippocampus.
In
this
study,
we
performed
an
in-silico
analysis
identify
single-nucleotide
polymorphisms
(SNPs)
genes
relevant
adult
neurogenesis
C58/J
model
of
idiopathic
autism.
We
found
coding
non-synonymous
(Cn)
SNPs
33
involved
process,
as
well
142
associated
signature
genetic
profile
neural
stem
cells
(NSC)
progenitors.
Based
on
potential
predicted
by
analysis,
evaluated
number
distribution
newborn
neurons
dentate
gyrus
(DG)
young
mice.
a
reduced
whole
DG,
higher
proportion
early
neuroblasts
subgranular
layer
(SGZ),
lower
morphological
maturation
signs
granule
cell
(GCL)
DG
compared
C57BL/6J
The
observed
changes
may
be
delay
trajectory
strain,
Cn
neurogenesis.
Язык: Английский
O-GlcNAc Transferase Congenital Disorder of Glycosylation (OGT-CDG): Potential mechanistic targets revealed by evaluating the OGT interactome
Journal of Biological Chemistry,
Год журнала:
2024,
Номер
300(9), С. 107599 - 107599
Опубликована: Июль 24, 2024
O-GlcNAc
transferase
(OGT)
is
the
sole
enzyme
responsible
for
post-translational
modification
of
on
thousands
target
nucleocytoplasmic
proteins.
To
date,
nine
variants
OGT
that
segregate
with
Congenital
Disorder
Glycosylation
(OGT-CDG)
have
been
reported
and
characterized.
Numerous
additional
associated
OGT-CDG,
some
which
are
currently
undergoing
investigation.
This
disorder
primarily
presents
global
developmental
delay
intellectual
disability
(ID),
alongside
other
variable
neurological
features
subtle
facial
dysmorphisms
in
patients.
Several
hypotheses
aim
to
explain
etiology
a
prominent
hypothesis
attributing
pathophysiology
OGT-CDG
mutations
segregating
this
disrupting
interactome.
The
interactome
consists
proteins,
including
substrates
as
well
interactors
require
noncatalytic
functions
OGT.
A
key
field
identify
contribute
neural-specific
phenotype
OGT-CDG.
In
review,
we
will
discuss
heterogenous
phenotypic
seen
clinically,
biochemical
effects
use
animal
models
understand
disorder.
Furthermore,
how
previously
identified
causal
ID
provide
mechanistic
targets
investigation
could
dysregulated
gene
expression
models.
Identifying
shared
or
unique
altered
pathways
impacted
patients
better
understanding
potential
therapeutic
targets.
Язык: Английский
Artificial Intelligence and Machine Learning Models for Alzheimer's Disease
Ananya Gambhir,
Ansh Bansal,
Saurabh Rawat
и другие.
Advances in media, entertainment and the arts (AMEA) book series,
Год журнала:
2024,
Номер
unknown, С. 102 - 117
Опубликована: Янв. 10, 2024
Alzheimer's
disease
is
a
brain
disorder
that
slowly
destroys
memory
and
thinking
skills
and,
eventually,
the
ability
to
carry
out
simplest
tasks.
In
most
people
with
disease,
those
late-onset
type
symptoms
first
appear
in
their
mid-60s.
Early-onset
occurs
between
person's
30s
mid-60s
very
rare.
common
cause
of
dementia
among
older
adults.
Early
diagnosis
essential
for
progress
more
prevailing
treatments.
Machine
learning
(ML),
branch
artificial
intelligence,
employs
variety
probabilistic
optimization
techniques
permits
PCs
gain
from
vast
complex
datasets.
As
result,
researchers
focus
on
using
machine
frequently
early
stages
disease.
This
project
presents
review,
analysis
critical
evaluation
recent
work
done
detection
ML
techniques.
Язык: Английский
USP9X deubiquitinates TRRAP to promote glioblastoma cell proliferation and migration and M2 macrophage polarization
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 29, 2024
Язык: Английский
Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Окт. 3, 2024
Язык: Английский
Bio-Metal Dyshomeostasis-Associated Acceleration of Aging and Cognitive Decline in Down Syndrome
Biological and Pharmaceutical Bulletin,
Год журнала:
2023,
Номер
46(9), С. 1169 - 1175
Опубликована: Авг. 31, 2023
Down
syndrome
(DS),
which
is
caused
by
triplication
of
human
chromosome
21
(Hsa21),
exhibits
some
physical
signs
accelerated
aging,
such
as
graying
hair,
wrinkles
and
menopause
at
an
unusually
young
age.
Development
early-onset
Alzheimer's
disease,
frequently
observed
in
adults
with
DS,
also
suggested
to
occur
due
aging
the
brain.
Several
Hsa21
genes
are
be
responsible
for
DS.
In
this
review,
we
summarize
these
candidate
possible
molecular
mechanisms,
discuss
related
key
factors.
particular,
focus
on
copper,
essential
trace
element,
a
factor
addition,
physiological
significance
brain
copper
accumulation
cognitive
impairment
discussed.
We
herein
provide
our
hypothesis
dyshomeostasis-based
pathophysiology
Язык: Английский