Advances in Liposomal Nanotechnology: From Concept to Clinics

RSC Pharmaceutics, Год журнала: 2024, Номер 1(5), С. 928 - 948

Опубликована: Янв. 1, 2024

A schematic diagram of a liposome's structure, highlighting its lipid bilayer. The illustration shows drug molecules encapsulated within the core or between phospholipid layers, offering insight into role in delivery systems.

Язык: Английский

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Current research status, applications and challenges of ketorolac-based sustained-release and controlled-release formulations

International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125162 - 125162

Опубликована: Янв. 8, 2025

Язык: Английский

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PEGylated Nanoliposomes Encapsulated with Anticancer Drugs for Breast and Prostate Cancer Therapy: An Update

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 190 - 190

Опубликована: Фев. 4, 2025

There are different types of cancer treatments, including surgery, radiotherapy, and chemotherapy. However, the complexity has resulted in treatment challenges to medicinal scientists a socio-economic burden public health system globally. The pharmacological limitations associated with current conventional anticancer drugs include lack specificity, poor bioavailability, toxicity, drug resistance, delivery mechanisms, which make challenging. Thus, number cases is escalating rapidly, especially breast prostate women men, respectively. application nanoformulations gaining momentum for treating types. they also exhibit that must be addressed effective treatment. Nanoliposomes widely explored interesting therapeutic outcomes. They have been functionalized PEG further improve their Hence, this review provides an update on PEGylated nanoliposomes loaded cancer, focusing pre-clinical studies published last decade (2015 2024) reflect recent advancements made design PEGylation nanoliposomes. Highlights clinically commercially available presented review.

Язык: Английский

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The Influence of β-Carotene and Its Liposomal Form on the Expression of EMT Markers and Androgen-Dependent Pathways in Different Prostate Cell Lines

Antioxidants, Год журнала: 2024, Номер 13(8), С. 902 - 902

Опубликована: Июль 25, 2024

Prostate cancer (PCa) is the most common malignancy in men. Although prognosis early stages good, treatment of advanced PCa remains a formidable challenge. Even after an initial response to hormone therapy or chemotherapy, recurrences are frequent and resistance any systemic common. β-Carotene (BC), plant-derived tetraterpene, known for its antioxidant capacity can modulate multiple cellular signaling pathways, potentially affecting androgen synthesis. We investigated influence BC (dissolved EtOH/THF with cell culture medium encapsulated liposomes (LP-BCs)) on viability, migration potential, connective tissue cleavage capabilities several lines (Du145, LNCaP, PC-3, 22Rv1) healthy prostate model (RWPE cells). significantly reduced proliferative all at various concentrations (1.5-30 µM) decreased migration. However, it increased expression epidermal-mesenchymal transition (EMT) master proteins RWPE (

Язык: Английский

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Nanomedicine: Bridging Nanoscience Innovations with Healthcare Solutions

Nanotechnology in the life sciences, Год журнала: 2024, Номер unknown, С. 133 - 147

Опубликована: Янв. 1, 2024

Язык: Английский

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