The Connection Between Oxidative Stress, Mitochondrial Dysfunction, Iron Metabolism and Microglia in Multiple Sclerosis: A Narrative Review
NeuroSci,
Год журнала:
2025,
Номер
6(1), С. 23 - 23
Опубликована: Март 4, 2025
In
recent
years,
in
the
pathogenesis
of
multiple
sclerosis,
emphasis
has
been
placed
on
mitochondrial
processes
that
influence
onset
disease.
Oxidative
stress
would
be
one
consequences
dysfunction,
and
its
impact
brain
tissue
is
well
described.
Microglia,
as
a
macrophage,
have
an
important
function
removing
unwanted
metabolites,
iron,
which
amplifier
oxidative
stress.
There
are
novelties
terms
connection
between
these
processes,
redirected
research
more
towards
process
neurodegeneration
itself,
so
no
longer
neuroinflammation,
initiate
pathological
itself
still
exist
vicinity
lesions
with
reduced
intensity.
The
aim
this
review
to
summarize
current
knowledge
from
literature
regarding
stress,
dysfunction
iron
metabolism
how
microglia
involved
sclerosis.
Язык: Английский
Co-supplementation of synbiotics and anti-inflammatory-antioxidant rich diet in patients with progressive forms of multiple sclerosis: A single-center, randomized clinical trial
Mediterranean Journal of Nutrition and Metabolism,
Год журнала:
2024,
Номер
17(2), С. 133 - 147
Опубликована: Фев. 2, 2024
BACKGROUND:
The
relationship
between
dietary
modification
and
Multiple
Sclerosis
(MS)-related
disability
has
been
emphasized
in
several
researches.
AIMS:
To
determine
whether
a
co-administration
of
anti-inflammatory-antioxidant
rich
diet
synbiotics
might
improve
clinical
manifestations
progressive
MS
patients.
METHODS:
study
involved
70
patients
with
(primary-progressive,
secondary-progressive,
progressive-relapsing)
who
were
randomized
to
receive
either
intervention
(synbiotics
capsule
plus
an
anti-inflammatory-antioxidant-rich
diet)
or
placebo.
Quality
Life
(QOL),
Expanded
Disability
Status
Scale
(EDSS),
depression-anxiety
scores
evaluated
before
after
the
follow-up.
Analysis
covariance
was
performed
for
final
analysis
(SPSS
v.14).
RESULTS:
Significant
reductions
seen
EDSS
(2.6±1.1
2.4±1.0,
P
<
0.001),
State
Anxiety
Inventory
(53.7±10.3
47.8±10.6,
QOL
four
months
intervention.
No
significant
difference
across
depression
severity
(Δ
=
–2.2±5.5
vs.
Δ
control
–0.6±5.7;
0.264).
CONCLUSION:
This
demonstrates
that
combination
could
be
promising
strategy
MS.
Язык: Английский
Effect of diet on the microbiota and immune system in patients with systemic lupus erythematosus
Food and Agricultural Immunology,
Год журнала:
2024,
Номер
35(1)
Опубликована: Ноя. 30, 2024
Systemic
lupus
erythematosus
(SLE)
is
a
chronic
autoimmune
disease
characterized
by
widespread
inflammation
and
organ
damage.
Studies
indicate
that
diet
significantly
influences
the
gut
microbiota,
which,
in
turn,
affects
immune
system.
This
article
explores
microbiota
dysbiosis
SLE
patients
potential
mechanisms
related
to
dietary
interventions
function.
It
highlights
specific
patterns,
such
as
high-fibre
Mediterranean
diet,
may
modulate
diversity
activity
of
microbiota.
The
interaction
between
altered
responses,
including
regulation
inflammatory
cytokines,
intestinal
barrier
permeability,
autoantibody
production
examined.
review
importance
personalized
strategies
enhancing
response
potentially
mitigating
progression.
Язык: Английский
Probiotics as Potential Treatments for Neurodegenerative Diseases: a Review of the Evidence from in vivo to Clinical Trial
Biomolecules & Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Neurodegenerative
diseases
(NDDs),
characterized
by
the
progressive
deterioration
of
structure
and
function
nervous
system,
represent
a
significant
global
health
challenge.Emerging
research
suggests
that
gut
microbiota
plays
critical
role
in
regulating
neurodegeneration
via
modulation
gut-brain
axis.Probiotics,
defined
as
live
microorganisms
confer
benefits
to
host,
have
garnered
attention
owing
their
therapeutic
potential
NDDs.This
review
examines
current
trends
related
microbiome-gut-brain
axis
across
various
NDDs,
highlighting
key
findings
implications.Additionally,
effects
specific
probiotic
strains,
including
Lactobacillus
plantarum,
Bifidobacterium
breve,
rhamnosus,
on
neurodegenerative
processes
were
assessed,
focusing
benefits.Overall,
this
emphasizes
probiotics
promising
agents
for
underscoring
importance
further
investigation
into
emerging
field.
Язык: Английский
Antioxidant Therapies in the Treatment of Multiple Sclerosis
Biomolecules,
Год журнала:
2024,
Номер
14(10), С. 1266 - 1266
Опубликована: Окт. 8, 2024
Several
studies
have
proposed
a
potential
role
for
oxidative
stress
in
the
development
of
multiple
sclerosis
(MS).
For
this
reason,
it
seems
tentative
to
think
that
treatment
with
antioxidant
substances
could
be
useful
disease.
In
narrative
review,
we
provide
summary
current
findings
on
treatments,
both
experimental
models
MS,
especially
autoimmune
encephalomyelitis
(EAE)
and
cuprizone-induced
demyelination
model,
clinical
trials
patients
diagnosed
MS.
Practically
all
antioxidants
tested
MS
shown
improvement
parameters,
delaying
evolution
disease,
improving
histological
biochemical
including
decreased
levels
markers
inflammation
central
nervous
system
other
tissues.
Only
few
been
carried
out
investigate
efficacy
most
them
short
term
involving
series
patients,
so
results
these
should
considered
inconclusive.
regard,
would
desirable
design
long-term,
randomized,
multicenter
long
assessing
several
demonstrated
Язык: Английский
Effect of Mediterranean diet on body mass index and fatigue severity in patients with multiple sclerosis: a systematic review and meta-analysis of clinical trials
Heliyon,
Год журнала:
2024,
Номер
10(18), С. e37705 - e37705
Опубликована: Сен. 1, 2024
Язык: Английский
New therapeutic avenues in multiple sclerosis: is there a place for gut microbiota-based treatments?
Pharmacological Research,
Год журнала:
2024,
Номер
209, С. 107456 - 107456
Опубликована: Окт. 9, 2024
The
bidirectional
interaction
between
the
gut
and
central
nervous
system
(CNS),
so-called
microbiota-brain
axis,
is
reported
to
influence
brain
functions,
thus
having
a
potential
impact
on
development
or
progression
of
several
neurodegenerative
disorders.
Within
this
context,
it
has
been
documented
that
multiple
sclerosis
(MS),
an
autoimmune
inflammatory,
demyelinating,
disease
CNS,
associated
with
gastrointestinal
symptoms,
including
constipation,
dysphagia,
faecal
incontinence.
Moreover,
some
evidence
suggests
existence
altered
microbiota
(GM)
composition
in
MS
patients
respect
healthy
individuals,
as
well
GM
dysbiosis
typical
features,
increased
intestinal
permeability,
disruption
blood-brain
barrier
integrity,
chronic
inflammation,
T
cells
differentiation.
Starting
from
these
assumptions,
possible
involvement
alteration
pathogenesis
seems
likely,
its
restoration
could
represent
supplemental
beneficial
strategy
against
disabling
disease.
In
regard,
present
review
will
explore
preventive
approaches
(including
dietary
interventions,
administration
probiotics,
prebiotics,
synbiotics,
postbiotics,
use
transplantation)
be
pursued
prophylaxis
combination
pharmacological
treatments
aim
re-establishing
proper
GM,
helping
prevent
manage
by
alleviating
symptoms
slowing
down
progression.
Язык: Английский
Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review
International Journal of General Medicine,
Год журнала:
2024,
Номер
Volume 17, С. 5941 - 5958
Опубликована: Дек. 1, 2024
In
recent
years,
probiotics,
as
a
class
of
biologically
active
microorganisms,
have
increasingly
attracted
attention
for
their
potential
in
treating
neurodegenerative
diseases
(NDDs).
To
comprehensively
assess
the
effects
probiotics
on
clinical
symptoms
and
systemic
inflammation
regulation
various
NDDs,
this
systematic
review
conducted
detailed
search
Cochrane
Library,
Embase,
PubMed,
Web
Science
databases,
ultimately
including
22
eligible
randomized
controlled
trials
(RCTs),
with
4
RCTs
Alzheimer's
Disease
(AD),
10
Parkinson's
(PD),
2
Multiple
Sclerosis
(MS),
Mild
Cognitive
Impairment
(MCI),
intervention
durations
ranging
from
to
16
weeks.
The
comprehensive
analysis
indicates
that
help
improve
related
gastrointestinal
function,
cognitive
quality
life,
mental
health.
Additionally,
generally
positive
effect
reducing
enhancing
antioxidant
capacity
patients.
conclusion,
existing
evidence
supports
promising
NDDs.
However,
further
large-scale,
high-quality
studies
are
needed
explore
specific
differences
efficacy
among
probiotic
strains,
dosages,
modes
administration.
Moreover,
considering
lifestyle
dietary
habits
may
modulate
these
external
factors
should
also
be
included
research
considerations
gain
more
understanding
mechanisms
application
strategies
NDDs
treatment.
Язык: Английский