Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review DOI Creative Commons
Fengya Zhu,

Shao Yin,

Yuan Wang

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 5941 - 5958

Published: Dec. 1, 2024

In recent years, probiotics, as a class of biologically active microorganisms, have increasingly attracted attention for their potential in treating neurodegenerative diseases (NDDs). To comprehensively assess the effects probiotics on clinical symptoms and systemic inflammation regulation various NDDs, this systematic review conducted detailed search Cochrane Library, Embase, PubMed, Web Science databases, ultimately including 22 eligible randomized controlled trials (RCTs), with 4 RCTs Alzheimer's Disease (AD), 10 Parkinson's (PD), 2 Multiple Sclerosis (MS), Mild Cognitive Impairment (MCI), intervention durations ranging from to 16 weeks. The comprehensive analysis indicates that help improve related gastrointestinal function, cognitive quality life, mental health. Additionally, generally positive effect reducing enhancing antioxidant capacity patients. conclusion, existing evidence supports promising NDDs. However, further large-scale, high-quality studies are needed explore specific differences efficacy among probiotic strains, dosages, modes administration. Moreover, considering lifestyle dietary habits may modulate these external factors should also be included research considerations gain more understanding mechanisms application strategies NDDs treatment.

Language: Английский

The Connection Between Oxidative Stress, Mitochondrial Dysfunction, Iron Metabolism and Microglia in Multiple Sclerosis: A Narrative Review DOI Creative Commons

Simonida Delic,

Svetlana Miletić Drakulić, Miloš Stepović

et al.

NeuroSci, Journal Year: 2025, Volume and Issue: 6(1), P. 23 - 23

Published: March 4, 2025

In recent years, in the pathogenesis of multiple sclerosis, emphasis has been placed on mitochondrial processes that influence onset disease. Oxidative stress would be one consequences dysfunction, and its impact brain tissue is well described. Microglia, as a macrophage, have an important function removing unwanted metabolites, iron, which amplifier oxidative stress. There are novelties terms connection between these processes, redirected research more towards process neurodegeneration itself, so no longer neuroinflammation, initiate pathological itself still exist vicinity lesions with reduced intensity. The aim this review to summarize current knowledge from literature regarding stress, dysfunction iron metabolism how microglia involved sclerosis.

Language: Английский

Citations

0
Co-supplementation of synbiotics and anti-inflammatory-antioxidant rich diet in patients with progressive forms of multiple sclerosis: A single-center, randomized clinical trial DOI
Amir Reza Moravejolahkami, Ahmad Chitsaz, Akbar Hassanzadeh

et al.

Mediterranean Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: 17(2), P. 133 - 147

Published: Feb. 2, 2024

BACKGROUND: The relationship between dietary modification and Multiple Sclerosis (MS)-related disability has been emphasized in several researches. AIMS: To determine whether a co-administration of anti-inflammatory-antioxidant rich diet synbiotics might improve clinical manifestations progressive MS patients. METHODS: study involved 70 patients with (primary-progressive, secondary-progressive, progressive-relapsing) who were randomized to receive either intervention (synbiotics capsule plus an anti-inflammatory-antioxidant-rich diet) or placebo. Quality Life (QOL), Expanded Disability Status Scale (EDSS), depression-anxiety scores evaluated before after the follow-up. Analysis covariance was performed for final analysis (SPSS v.14). RESULTS: Significant reductions seen EDSS (2.6±1.1 2.4±1.0, P < 0.001), State Anxiety Inventory (53.7±10.3 47.8±10.6, QOL four months intervention. No significant difference across depression severity (Δ = –2.2±5.5 vs. Δ control –0.6±5.7; 0.264). CONCLUSION: This demonstrates that combination could be promising strategy MS.

Language: Английский

Citations

2
Effect of diet on the microbiota and immune system in patients with systemic lupus erythematosus DOI Creative Commons
Viviana A. Ruiz‐Pozo,

Elius Paz-Cruz,

Santiago Cadena-Ullauri

et al.

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Nov. 30, 2024

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by widespread inflammation and organ damage. Studies indicate that diet significantly influences the gut microbiota, which, in turn, affects immune system. This article explores microbiota dysbiosis SLE patients potential mechanisms related to dietary interventions function. It highlights specific patterns, such as high-fibre Mediterranean diet, may modulate diversity activity of microbiota. The interaction between altered responses, including regulation inflammatory cytokines, intestinal barrier permeability, autoantibody production examined. review importance personalized strategies enhancing response potentially mitigating progression.

Language: Английский

Citations

2
Probiotics as Potential Treatments for Neurodegenerative Diseases: a Review of the Evidence from in vivo to Clinical Trial DOI Creative Commons
Jin Hee Kim, Yujin Choi, Seung-Min Lee

et al.

Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Neurodegenerative diseases (NDDs), characterized by the progressive deterioration of structure and function nervous system, represent a significant global health challenge.Emerging research suggests that gut microbiota plays critical role in regulating neurodegeneration via modulation gut-brain axis.Probiotics, defined as live microorganisms confer benefits to host, have garnered attention owing their therapeutic potential NDDs.This review examines current trends related microbiome-gut-brain axis across various NDDs, highlighting key findings implications.Additionally, effects specific probiotic strains, including Lactobacillus plantarum, Bifidobacterium breve, rhamnosus, on neurodegenerative processes were assessed, focusing benefits.Overall, this emphasizes probiotics promising agents for underscoring importance further investigation into emerging field.

Language: Английский

Citations

2
Antioxidant Therapies in the Treatment of Multiple Sclerosis DOI Creative Commons
Félix Javier Jiménez‐Jiménez, Hortensia Alonso‐Navarro, Paula Salgado-Cámara

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1266 - 1266

Published: Oct. 8, 2024

Several studies have proposed a potential role for oxidative stress in the development of multiple sclerosis (MS). For this reason, it seems tentative to think that treatment with antioxidant substances could be useful disease. In narrative review, we provide summary current findings on treatments, both experimental models MS, especially autoimmune encephalomyelitis (EAE) and cuprizone-induced demyelination model, clinical trials patients diagnosed MS. Practically all antioxidants tested MS shown improvement parameters, delaying evolution disease, improving histological biochemical including decreased levels markers inflammation central nervous system other tissues. Only few been carried out investigate efficacy most them short term involving series patients, so results these should considered inconclusive. regard, would desirable design long-term, randomized, multicenter long assessing several demonstrated

Language: Английский

Citations

1
Effect of Mediterranean diet on body mass index and fatigue severity in patients with multiple sclerosis: a systematic review and meta-analysis of clinical trials DOI Creative Commons
Amir Reza Moravejolahkami, Mehdi Shakibaei, Manoj Sharma

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37705 - e37705

Published: Sept. 1, 2024

Language: Английский

Citations

0
New therapeutic avenues in multiple sclerosis: is there a place for gut microbiota-based treatments? DOI Creative Commons
Lucrezia Irene Maria Campagnoli, Nicoletta Marchesi, Angelica Varesi

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107456 - 107456

Published: Oct. 9, 2024

The bidirectional interaction between the gut and central nervous system (CNS), so-called microbiota-brain axis, is reported to influence brain functions, thus having a potential impact on development or progression of several neurodegenerative disorders. Within this context, it has been documented that multiple sclerosis (MS), an autoimmune inflammatory, demyelinating, disease CNS, associated with gastrointestinal symptoms, including constipation, dysphagia, faecal incontinence. Moreover, some evidence suggests existence altered microbiota (GM) composition in MS patients respect healthy individuals, as well GM dysbiosis typical features, increased intestinal permeability, disruption blood-brain barrier integrity, chronic inflammation, T cells differentiation. Starting from these assumptions, possible involvement alteration pathogenesis seems likely, its restoration could represent supplemental beneficial strategy against disabling disease. In regard, present review will explore preventive approaches (including dietary interventions, administration probiotics, prebiotics, synbiotics, postbiotics, use transplantation) be pursued prophylaxis combination pharmacological treatments aim re-establishing proper GM, helping prevent manage by alleviating symptoms slowing down progression.

Language: Английский

Citations

0
Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review DOI Creative Commons
Fengya Zhu,

Shao Yin,

Yuan Wang

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 5941 - 5958

Published: Dec. 1, 2024

In recent years, probiotics, as a class of biologically active microorganisms, have increasingly attracted attention for their potential in treating neurodegenerative diseases (NDDs). To comprehensively assess the effects probiotics on clinical symptoms and systemic inflammation regulation various NDDs, this systematic review conducted detailed search Cochrane Library, Embase, PubMed, Web Science databases, ultimately including 22 eligible randomized controlled trials (RCTs), with 4 RCTs Alzheimer's Disease (AD), 10 Parkinson's (PD), 2 Multiple Sclerosis (MS), Mild Cognitive Impairment (MCI), intervention durations ranging from to 16 weeks. The comprehensive analysis indicates that help improve related gastrointestinal function, cognitive quality life, mental health. Additionally, generally positive effect reducing enhancing antioxidant capacity patients. conclusion, existing evidence supports promising NDDs. However, further large-scale, high-quality studies are needed explore specific differences efficacy among probiotic strains, dosages, modes administration. Moreover, considering lifestyle dietary habits may modulate these external factors should also be included research considerations gain more understanding mechanisms application strategies NDDs treatment.

Language: Английский

Citations

0