An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(11), С. 5938 - 5938

Опубликована: Май 25, 2022

Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress several neurodegenerative disorders. This review intends to summarize some findings that correlate overproduction reactive oxygen species pathophysiology Alzheimer’s disease, Parkinson’s Huntington’s and amyotrophic lateral sclerosis. was also noted modify inflammatory response. Even though oxidative neuroinflammation are two totally different pathological events, they affect one another. Nonetheless, there still mechanisms need be understood regarding onset diseases order develop efficient therapies. As antioxidants means alter slow down symptoms these most common antioxidants, enzymatic as well non-enzymatic, have mentioned this paper therapeutic options for discussed

Язык: Английский

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Natural product-derived phytochemicals as potential agents against coronaviruses: A review

Virus Research, Год журнала: 2020, Номер 284, С. 197989 - 197989

Опубликована: Апрель 30, 2020

Язык: Английский

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Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

Frontiers in Aging Neuroscience, Год журнала: 2021, Номер 13

Опубликована: Фев. 18, 2021

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are essential for the numerous biochemical processes underpinning cell viability. Mitochondrial morphology changes rapidly response to external insults metabolic status via fission fusion (so-called mitochondrial dynamics) that maintain quality homeostasis. Damaged mitochondria removed by process known as mitophagy, involves their degradation specific autophagosomal pathway. Over last few years, remarkable efforts have been made investigate impact on pathogenesis of Alzheimer's disease (AD) various forms dysfunction, such excessive reactive oxygen species (ROS) production, Ca2+ dyshomeostasis, loss ATP, defects dynamics transport, mitophagy. Recent research suggests restoration function physical exercise, an antioxidant diet, or therapeutic approaches can delay onset slow progression AD. In this review, we focus recent progress highlights crucial alterations oxidative stress AD, emphasizing framework existing potential approaches.

Язык: Английский

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A role for quercetin in coronavirus disease 2019 (COVID‐19)

Phytotherapy Research, Год журнала: 2020, Номер 35(3), С. 1230 - 1236

Опубликована: Окт. 9, 2020

Several months ago, an outbreak of pneumonia unknown aetiology was detected in Wuhan City (China) and the aetiological agent atypical isolated by Chinese authorities as novel coronavirus (2019‐nCoV or SARS‐CoV‐2). The WHO announced this new disease to be known “COVID‐19.” When looking for antiviral compounds, knowledge main viral proteins is fundamental. major druggable targets SARS‐CoV‐2 include 3‐chymotrypsin‐like protease (3CLpro), papain‐like (PLpro), RNA‐dependent RNA polymerase, spike (S) protein. Quercetin inhibits 3CLpro PLpro with a docking binding energy corresponding −6.25 −4.62 kcal/mol, respectively. has theoretical, but significant, capability interfere replication, results showing fifth best compound out 18 candidates. On basis clinical COVID‐19 manifestations, multifaceted aspect quercetin both antiinflammatory thrombin‐inhibitory actions, should taken into consideration.

Язык: Английский

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The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?

Cell Stress and Chaperones, Год журнала: 2021, Номер 26(6), С. 871 - 887

Опубликована: Авг. 13, 2021

Among the long list of age-related complications, Alzheimer's disease (AD) has most dreadful impact on quality life due to its devastating effects memory and cognitive abilities. Although a plausible correlation between phosphatidylinositol 3-kinase (PI3K) signaling different processes involved in neurodegeneration been evidenced, few articles reviewed task. The current review aims unravel mechanisms by which PI3K pathway plays pro-survival roles normal conditions, also discuss original data obtained from international research laboratories this topic. Responses questions how alterations PI3K/Akt affect Tau phosphorylation amyloid cascade are given. In addition, we provide general overview association oxidative stress, neuroinflammation, insulin signaling, altered autophagy with aberrant activation axis AD brain. last section provides special focus therapeutic possibility PI3K/Akt/mTOR modulators, either categorized as chemicals or herbals, AD. conclusion, determining correct timing for administration drugs seems be one important factors success these agents. Also, role progression repression widely depends context cells; generally speaking, while neurons neural stem cells is favorable, microglia may harmful.

Язык: Английский

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Alzheimer’s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs

Biochemical Pharmacology, Год журнала: 2023, Номер 211, С. 115522 - 115522

Опубликована: Март 28, 2023

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that affect millions people worldwide, with both prevalence and incidence increasing age. It characterized by cognitive decline associated, specifically, degeneration cholinergic neurons. The problem this even more fundamental as available therapies remain fairly limited mainly focused on symptoms' relief. Although aetiology remains elusive, two main pathological hallmarks are described: i) presence neurofibrillary tangles formed unfolded protein aggregates (hyperphosphorylated Tau protein) ii) extracellular amyloid-beta peptide. Given complexity surrounding pathogenesis disease, several potential targets have been highlighted interrelated upon its progression, such oxidative stress accumulation metal ions. Thus, advances made development innovative multitarget therapeutical compounds to delay progression restore cell function. This review focuses ongoing research new insights emerging disease-modifying drugs for AD treatment. Furthermore, classical novel biomarkers early diagnosis their role in assisting improvement targeted will also be approached.

Язык: Английский

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Iron Homeostasis Disorder and Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(22), С. 12442 - 12442

Опубликована: Ноя. 18, 2021

Iron is an essential trace metal for almost all organisms, including human; however, oxidative stress can easily be caused when iron in excess, producing toxicity to the human body due its capability both electron donor and acceptor. Although there a strict regulation mechanism homeostasis brain, it usually inevitably disturbed by genetic environmental factors, or disordered with aging, which leads metabolism diseases, many neurodegenerative diseases such as Alzheimer’s disease (AD). AD one of most common degenerative central nervous system (CNS) threatening health. However, precise pathogenesis still unclear, seriously restricts design interventions treatment drugs based on AD. Many studies have observed abnormal accumulation different regions resulting cognitive, memory, motor other nerve damages. Understanding metabolic balance brain crucial AD, would provide new cures disease. This paper reviews recent progress relationship between from aspects absorption intestinal cells, storage cells organs, especially prospects future directions treatments.

Язык: Английский

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Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6518 - 6518

Опубликована: Март 30, 2023

Alzheimer’s disease is one of the most commonly diagnosed cases senile dementia in world. It an incurable process, often leading to death. This multifactorial, and factor this inflammation. Numerous mediators secreted by inflammatory cells can cause neuronal degeneration. Neuritis may coexist with other mechanisms disease, contributing progression, also directly underlie AD. Although much has been established about processes pathogenesis AD, many aspects remain unexplained. The work devoted particular pathomechanism inflammation its role diagnosis treatment. An in-depth detailed understanding neuroinflammation help development diagnostic methods for early contribute new therapeutic strategies disease.

Язык: Английский

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An ethnopharmacological review on the therapeutical properties of flavonoids and their mechanisms of actions: A comprehensive review based on up to date knowledge

Toxicology Reports, Год журнала: 2022, Номер 9, С. 445 - 469

Опубликована: Янв. 1, 2022

Flavonoids -a class of low molecular weight secondary metabolites- are ubiquitous and cornucopia throughout the plant kingdom. Structurally, main structure consists C6-C3-C6 rings with different substitution patterns so that many sub-classes obtained, for example: flavonols, flavonolignans, flavonoid glycosides, flavans, anthocyanidins, aurones, flavones, neoflavonoids, chalcones, isoflavones, flavones flavanones. evaluated to have drug like nature since they possess therapeutic activities, can act as cardioprotective, antiviral, antidiabetic, anti-inflammatory, antibacterial, anticancer, also work against Alzheimer's disease others. However, information on relationship between their biological activity is scarce. Therefore, present review tries summarize all activities flavonoids, mechanisms action relationship.

Язык: Английский

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Oxidative stress in Alzheimer’s disease: current knowledge of signaling pathways and therapeutics

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Янв. 2, 2024

Язык: Английский

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