Nutrients,
Год журнала:
2021,
Номер
13(5), С. 1591 - 1591
Опубликована: Май 10, 2021
Probiotic
bacteria
are
widely
accepted
as
therapeutic
agents
against
inflammatory
bowel
diseases
for
their
immunostimulating
effects.
In
the
last
decade,
more
evidence
has
emerged
supporting
positive
effects
of
probiotics
on
course
neurodegenerative
and
psychiatric
diseases.
This
brief
review
summarizes
data
from
clinical
studies
possessing
antidepressant
properties
focuses
potential
genes
proteins
underlying
these
mechanisms.
Data
small-sample
placebo-controlled
pilot
indicate
that
certain
strains
can
significantly
reduce
symptoms
depression,
especially
in
depressed
patients.
Despite
disparity
between
attempting
to
pinpoint
bacterial
putative
accounting
mechanisms,
they
ultimately
show
a
source
metabiotics-microbial
metabolites
or
structural
components.
Since
constituents
cells-namely,
secreted
proteins,
peptides
cell
wall
components-are
most
likely
be
entangled
gut-brain
axis,
serve
starting
point
search
with
concrete
properties.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 1314 - 1314
Опубликована: Янв. 21, 2024
Mitochondria
are
critical
for
providing
energy
to
maintain
cell
viability.
Oxidative
phosphorylation
involves
the
transfer
of
electrons
from
substrates
oxygen
produce
adenosine
triphosphate.
also
regulate
proliferation,
metastasis,
and
deterioration.
The
flow
in
mitochondrial
respiratory
chain
generates
reactive
species
(ROS),
which
harmful
cells
at
high
levels.
stress
caused
by
ROS
accumulation
has
been
associated
with
an
increased
risk
cancer,
cardiovascular
liver
diseases.
Glutathione
(GSH)
is
abundant
cellular
antioxidant
that
primarily
synthesized
cytoplasm
delivered
mitochondria.
Mitochondrial
glutathione
(mGSH)
metabolizes
hydrogen
peroxide
within
A
long-term
imbalance
ratio
mGSH
can
cause
dysfunction,
apoptosis,
necroptosis,
ferroptosis,
may
lead
disease.
This
study
aimed
review
physiological
functions,
anabolism,
variations
organ
tissue
accumulation,
delivery
GSH
mitochondria
relationships
between
levels,
GSH/GSH
disulfide
(GSSG)
ratio,
programmed
death,
ferroptosis.
We
discuss
diseases
deficiency
related
therapeutics.
Nutritional Neuroscience,
Год журнала:
2021,
Номер
25(8), С. 1659 - 1668
Опубликована: Фев. 28, 2021
Background
It
has
been
shown
that
dysbiosis
might
have
a
role
in
developing
of
chronic
inflammation
and
depression.
In
this
study,
we
are
interested
exploring
anti-inflammatory
anti-depressant
effects
Lactobacillus
Rhamnosus
G
(LGG),
probiotic
strain,
alone
or
combination
with
prebiotic,
Inulin,
patients
coronary
artery
disease
(CAD).Methods
This
randomized,
double-blind
clinical
trial
was
held
on
96
CAD.
Patients
were
randomly
allocated
into
four
different
groups:
LGG
[a
capsule/day,
contained
1.9
×
109
colony-forming
unit
G],
inulin
(15
g/day),
co-supplemented
(LGG
inulin),
placebo.
Participants
consumed
the
supplements
for
two
months.
Beck
Depression
Inventory
(BDI),
MacNew
questionnaire
Spielberger
state-trait
anxiety
inventory
(STAI-Y)
used
to
assess
depression,
quality
life
anxiety,
respectively.
Serum
levels
C-reactive
protein
(hs-CRP),
lipopolysaccharide
(LPS),
tumor
necrosis
factor
(TNF)-α,
Interleukin
(IL)-10
also
measured.Results
Probiotic-Inulin
Co-supplementation
significantly
decreased
BDI
(−11.52
±
0+3.20
vs.
+2.97
0.39,
P
=
0.001),
STAI-state
(−17.63
3.22
−0.60
0.33,
0.021),
STAI-trait
(−24.31
7.41
−1.45
0.66,
0.020)
scores,
hs-CRP
(−1.69
0+66
+0.82
0.39
mg/dL,
0.020),
LPS
(−22.02
5.40
+0.31
0.18
(EU/L),
0.047),
TNF-α
(−25.05
+0.79
0.71
(ng/L),
0.032)
comparison
placebo.Conclusion
probiotics
CAD
subjects
eight
weeks
had
beneficial
inflammatory
biomarkers.
Adding
improved
psychological
outcomes
biomarkers
more
effectively
than
separately.Trial
registration:
Iranian
Registry
Clinical
Trials
identifier:
IRCT20180712040438N4..
Journal of Clinical Medicine,
Год журнала:
2021,
Номер
10(4), С. 647 - 647
Опубликована: Фев. 8, 2021
Recent
years
have
seen
a
rapid
increase
in
the
use
of
gut
microbiota-targeting
interventions,
such
as
probiotics,
for
treatment
psychiatric
disorders.
The
objective
this
update
review
was
to
evaluate
all
randomised
controlled
clinical
trial
evidence
on
efficacy
probiotics
depression.
Cochrane
guidelines
updated
reviews
were
followed.
By
searching
PubMed
and
Web
Science
databases,
we
identified
546
new
records
since
our
previous
review.
A
total
seven
studies
met
selection
criteria,
capturing
404
people
with
random
effects
meta-analysis
using
type
(stand-alone
vs.
adjunctive)
subgroup
performed.
results
demonstrated
that
are
effective
reducing
depressive
symptoms
when
administered
addition
antidepressants
(SMD
=
0.83,
95%CI
0.49-1.17),
however,
they
do
not
seem
offer
significant
benefits
used
stand-alone
-0.02,
-0.34-0.30).
Potential
mechanisms
action
may
be
via
increases
brain-derived
neurotrophic
factor
(BDNF)
decreases
C-reactive
protein
(CRP),
although
limited
is
available
at
present.
This
offers
stronger
support
depressed
populations
provides
an
insight
into
mode
administration
more
likely
yield
antidepressant
effects.
Nutrients,
Год журнала:
2021,
Номер
13(5), С. 1728 - 1728
Опубликована: Май 20, 2021
The
field
of
probiotic
has
been
exponentially
expanding
over
the
recent
decades
with
a
more
therapeutic-centered
research.
Probiotics
mediated
microbiota
modulation
within
microbiota-gut-brain
axis
(MGBA)
have
proven
to
be
beneficial
in
various
health
domains
through
pre-clinical
and
clinical
studies.
In
context
mental
health,
although
research
is
still
its
infancy
stage,
promising
role
potential
probiotics
disorders
demonstrated
via
in-vivo
in-vitro
studies
laid
strong
foundation
for
translating
preclinical
models
humans.
exploration
therapeutic
major
depressive
disorder
(MDD)
an
extremely
noteworthy
possible
etio-pathological
mechanisms
depression
involving
inflammation,
neurotransmitters,
hypothalamic-pituitary-adrenal
(HPA)
epigenetic
potentially
benefit
from
intervention.
Probiotics,
both
as
adjunct
antidepressants
or
stand-alone
intervention,
mitigating
anti-depressive
effects,
confers
some
advantages
compared
conventional
treatments
using
anti-depressants.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
63(26), С. 8292 - 8300
Опубликована: Март 29, 2022
Growing
evidence
has
suggested
that
the
consumption
of
probiotics
can
decrease
depressive
symptoms.
However,
even
results
meta-analyses
are
conflicting.
In
this
regard,
we
performed
an
umbrella
meta-analysis
and
proposed
decisive
impacts
on
The
following
international
databases
were
searched
up
to
July
2021:
PubMed/Medline,
Web
Science,
Scopus,
EMBASE,
Google
Scholar.
Meta-analyses
investigating
impact
supplementation
depression
symptoms
in
adults
included.
According
studies,
random-effects
model
was
used
perform
analysis.
Subgroup
analysis
by
dosage
probiotics,
duration
total
sample
size.
Publication
bias
assessed
using
Egger's,
Begg's
visual
inspection
funnel
plot.
Ten
(n
=
8886
participants)
included
study.
pooled
data
indicated
probiotic
significantly
reduced
(ES=
−1.41;
95%
CI:
−2.53,
−0.30,
p
0.016;
I2
99.4,
<0.001).
studies
with
intervention
>8
weeks
>10
×
109
CFU
demonstrated
a
more
robust
effect
decreasing
There
also
significant
between-study
heterogeneity
which
identified
as
source
it.
present
suggest
administration
for
relieving
CFU.
Pharmacological Research,
Год журнала:
2023,
Номер
192, С. 106799 - 106799
Опубликована: Май 19, 2023
Depression
is
the
most
prevalent
mental
disorder
in
world
associated
with
huge
socio-economic
consequences.
While
depressive-related
symptoms
are
well
known,
molecular
mechanisms
underlying
disease
pathophysiology
and
progression
remain
largely
unknown.
The
gut
microbiota
(GM)
emerging
as
a
key
regulator
of
central
nervous
system
homeostasis
by
exerting
fundamental
immune
metabolic
functions.
In
turn,
brain
influences
intestinal
microbial
composition
through
neuroendocrine
signals,
within
so-called
microbiota-brain
axis.
balance
this
bidirectional
crosstalk
important
to
ensure
neurogenesis,
preserve
integrity
blood-brain
barrier
avoid
neuroinflammation.
Conversely,
dysbiosis
permeability
negatively
affect
development,
behavior,
cognition.
Furthermore,
although
not
fully
defined
yet,
changes
GM
depressed
patients
reported
influence
pharmacokinetics
common
antidepressants
affecting
their
absorption,
metabolism,
activity.
Similarly,
neuropsychiatric
drugs
may
shape
turn
an
impact
on
efficacy
toxicity
pharmacological
intervention
itself.
Consequently,
strategies
aimed
at
re-establishing
correct
homeostatic
(i.e.,
prebiotics,
probiotics,
fecal
transplantation,
dietary
interventions)
represent
innovative
approach
improve
pharmacotherapy
depression.
Among
these,
probiotics
Mediterranean
diet,
alone
or
combination
standard
care,
hold
promise
for
clinical
application.
Therefore,
disclosure
intricate
network
between
depression
will
give
precious
insights
diagnostic
therapeutic
approaches
towards
depression,
profound
implications
drug
development
practice.
Nutrients,
Год журнала:
2023,
Номер
15(6), С. 1382 - 1382
Опубликована: Март 13, 2023
Probiotics
are
currently
the
subject
of
intensive
research
pursuits
and
also
represent
a
multi-billion-dollar
global
industry
given
their
vast
potential
to
improve
human
health.
In
addition,
mental
health
represents
key
domain
healthcare,
which
has
limited,
adverse-effect
prone
treatment
options,
probiotics
may
hold
be
novel,
customizable
for
depression.
Clinical
depression
is
common,
potentially
debilitating
condition
that
amenable
precision
psychiatry-based
approach
utilizing
probiotics.
Although
our
understanding
not
yet
reached
sufficient
level,
this
could
therapeutic
can
tailored
specific
individuals
with
own
unique
set
characteristics
issues.
Scientifically,
use
as
valid
basis
rooted
in
microbiota-gut-brain
axis
(MGBA)
mechanisms,
play
role
pathophysiology
theory,
appear
ideal
adjunct
therapeutics
major
depressive
disorder
(MDD)
stand-alone
mild
MDD
revolutionize
disorders.
there
wide
range
an
almost
limitless
combinations,
review
aims
narrow
focus
most
widely
commercialized
studied
strains,
namely
Lactobacillus
Bifidobacterium,
bring
together
arguments
usage
patients
(MDD).
Clinicians,
scientists,
industrialists
critical
stakeholders
exploring
groundbreaking
concept.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Апрель 17, 2023
Depression
is
one
of
the
most
common
psychiatric
conditions,
characterized
by
significant
and
persistent
depressed
mood
diminished
interest,
often
coexists
with
various
comorbidities.
The
underlying
mechanism
depression
remain
elusive,
evidenced
lack
an
appreciate
therapy.
Recent
abundant
clinical
trials
animal
studies
support
new
notion
that
gut
microbiota
has
emerged
as
a
novel
actor
in
pathophysiology
depression,
which
partakes
bidirectional
communication
between
brain
through
neuroendocrine,
nervous,
immune
signaling
pathways,
collectively
known
microbiota-gut-brain
(MGB)
axis.
Alterations
can
trigger
changes
neurotransmitters,
neuroinflammation,
behaviors.
With
transition
human
microbiome
research
from
studying
associations
to
investigating
mechanistic
causality,
MGB
axis
therapeutic
target
its
These
insights
have
fueled
idea
targeting
on
may
open
windows
for
efficient
treatment
Probiotics,
live
beneficial
microorganisms,
be
used
modulate
dysbiosis
into
eubiosis
modify
occurrence
development
In
present
review,
we
summarize
recent
findings
regarding
discuss
potential
effects
probiotics
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5782 - 5782
Опубликована: Май 26, 2024
Nowadays,
depressive
disorder
is
spreading
rapidly
all
over
the
world.
Therefore,
attention
to
studies
of
pathogenesis
disease
in
order
find
novel
ways
early
diagnosis
and
treatment
increasing
among
scientific
medical
communities.
Special
drawn
a
biomarker
therapeutic
strategy
through
microbiota–gut–brain
axis.
It
known
that
symbiotic
interactions
between
gut
microbes
host
can
affect
mental
health.
The
review
analyzes
mechanisms
action
microbiota
on
pathophysiology
depression.
possibility
using
knowledge
about
taxonomic
composition
metabolic
profile
patients
with
depression
select
gene
compositions
(metagenomic
signature)
as
biomarkers
evaluated.
use
silico
technologies
(machine
learning)
for
based
given.
Alternative
approaches
are
being
considered
by
balancing
microbial
dietary
modifications
additives,
namely
probiotics,
postbiotics
(including
vesicles)
prebiotics
psychobiotics,
fecal
transplantation.
bacterium
Faecalibacterium
prausnitzii
under
consideration
promising
new-generation
probiotic
auxiliary
diagnostic
analysis
conducted
this
may
be
useful
clinical
practice
pharmacology.
Metabolites,
Год журнала:
2024,
Номер
14(10), С. 549 - 549
Опубликована: Окт. 14, 2024
Mental
health
is
an
increasing
topic
of
focus
since
more
than
500
million
people
in
the
world
suffer
from
depression
and
anxiety.
In
this
multifactorial
disorder,
parameters
such
as
inflammation,
state
microbiota
and,
therefore,
patient's
nutrition
are
receiving
attention.
addition,
food
products
source
many
essential
ingredients
involved
regulation
mental
processes,
including
amino
acids,
neurotransmitters,
vitamins,
others.
For
reason,
narrative
review
was
carried
out
with
aim
analyzing
role
anxiety
disorders.
To
reach
aim,
a
critical
conducted
utilizing
both
primary
sources,
scientific
publications
secondary
bibliographic
indexes,
web
pages,
databases.
The
search
PsychINFO,
MedLine
(Pubmed),
Cochrane
(Wiley),
Embase,
CinAhl.
results
show
direct
relationship
between
what
we
eat
our
nervous
system.
gut-brain
axis
complex
system
which
intestinal
communicates
directly
provides
it
neurotransmitters
for
its
proper
functioning.
An
imbalance
due
to
poor
will
cause
inflammatory
response
that,
if
sustained
over
time
together
other
factors,
can
lead
disorders
depression.
Changes
functions
microbiota-gut-brain
have
been
linked
several
It
believed
that
modulation
microbiome
composition
may
be
effective
strategy
new
treatment
these
Modifications
nutritional
behaviors
use
ergogenic
components
presented
important
non-pharmacological
interventions
prevention
treatment.
desirable
choice
probiotic
individual
patients
based
on
appropriate
biochemical
microbiological
tests.