Journal of Affective Disorders, Год журнала: 2023, Номер 343, С. 9 - 21
Опубликована: Сен. 20, 2023
Язык: Английский
Microorganisms, Год журнала: 2022, Номер 10(7), С. 1457 - 1457
Опубликована: Июль 19, 2022
Over the last few years, microbiome has emerged as a high-priority research area to discover missing links between brain health and gut dysbiosis. Emerging evidence suggests that commensal is an important regulator of gut–brain axis plays critical role in physiology. Engaging microbiome-generated metabolites such short-chain fatty acids, immune system, enteric nervous endocrine system (including HPA axis), tryptophan metabolism or vagus nerve crucial communication microbes brain. Humans are exposed wide range pollutants everyday life impact our intestinal microbiota manipulate bidirectional brain, resulting predisposition psychiatric neurological disorders. However, interaction xenobiotics, neurotoxicity yet be completely investigated. Although into precise processes microbiota–gut–brain growing rapidly, comprehending implications environmental contaminants remains challenging. In these milieus, we herein discuss how various phthalates, heavy metals, Bisphenol A particulate matter may alter intricate thereby impacting overall mental health.
Язык: Английский
Процитировано
72
Nutrients, Год журнала: 2024, Номер 16(4), С. 546 - 546
Опубликована: Фев. 16, 2024
Several billion microorganisms reside in the gastrointestinal lumen, including viruses, bacteria, fungi, and yeast. Among them, probiotics were primarily used to cure digestive disorders such as intestinal infections diarrhea; however, with a paradigm shift towards alleviating health through food, their importance is large. Moreover, recent studies have changed perspective that prevent numerous ailments major organs. Probiotics produce biologically active compounds targeting discommodious pathogens. This review demonstrates implications of using from different genres alleviate primary human The findings reveal immediately activate anti-inflammatory mechanisms by producing cytokines interleukin (IL)-4, IL-10, IL-11, IL-13, hindering pro-inflammatory IL-1, IL-6, TNF-α involving regulatory T cells (Tregs) helper (Th cells). strains Lactobacillus plantarum, rhamnosus, casei, reuteri, Bifidobacterium longum, breve been listed among are excellent various simple complex ailments. Therefore, necessitates robust research unveil probiotics, potency strains, optimal dosages, combination habitat host, host response, other pertinent factors.
Язык: Английский
Процитировано
44
Biomedicines, Год журнала: 2023, Номер 11(7), С. 1903 - 1903
Опубликована: Июль 5, 2023
Civilization diseases are defined as non-communicable that affect a large part of the population. Examples such depression and cardiovascular disease. Importantly, World Health Organization warns against an increase in both these. This narrative review aims to summarize available information on measurable risk factors for CVD based existing literature. The paper reviews epidemiology main coexistence authors emphasize there is evidence link between Here, we highlight common disease, including obesity, diabetes, physical inactivity, well importance prevention treatment preventing other mental disorders. Conversely, effective can also help prevent improve health outcomes. It seems advisable introduce screening tests patients treated cardiac reasons. mood disorders, it worth controlling factors, example, by checking blood pressure pulse during routine visits. paying attention condition with CVD. study underlines interdisciplinary co-operation.
Язык: Английский
Процитировано
42
Nutrients, Год журнала: 2021, Номер 13(8), С. 2878 - 2878
Опубликована: Авг. 21, 2021
Among cardiovascular diseases (CVDs), a major cause of morbidity and mortality worldwide, coronary heart disease stroke are the most well-known extensively studied. The onset progression CVD is associated with multiple risk factors, among which, gut microbiota has received much attention in past two decades. Gut microbiota, microbial community colonizing gut, plays prominent role human health. In particular, dysbiosis directly related to many acute or chronic dysfunctions system (CVS) host. Earlier studies have demonstrated that pathogenesis strongly linked intestinal imbalance inflammatory responses. Probiotics prebiotics conferring various health benefits on host emerging as promising therapeutic interventions for diseases. These types food supplements potential alleviate risks through improving levels several markers, such total low-density lipoprotein (LDL) cholesterol, high sensitivity C-reactive protein (hs-CRP), certain cytokines involved response. this review, we focus mainly preventive effects probiotics via rebalancing structural functional changes maintaining immune homeostasis.
Язык: Английский
Процитировано
92
Molecular Biomedicine, Год журнала: 2022, Номер 3(1)
Опубликована: Окт. 11, 2022
Abstract The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, metabolites interact with host. Meanwhile, increasing evidence indicates that has a strong correlation occurrence, progression treatment of cardiovascular diseases (CVDs). In patients CVDs corresponding risk factors, composition ratio have significant differences compared their healthy counterparts. Therefore, dysbiosis, microbiota-generated metabolites, related signaling pathway may serve explanations for some mechanisms about occurrence development CVDs. Several studies also demonstrated many traditional latest therapeutic treatments are associated its generated pathways. Given information, we summarized advances in current research regarding effect on main CVDs, highlighted roles several introduced promising microbiota. this review mainly focuses exploring role potential which eventually provide better solutions well prevention
Язык: Английский
Процитировано
67
Frontiers in Nutrition, Год журнала: 2021, Номер 8
Опубликована: Июнь 7, 2021
The occurrence and development of cardiovascular-related diseases are associated with structural functional changes in gut microbiota (GM). accumulation beneficial commensals contributes to the improvement diseases. that can be relieved by Lactobacillus supplementation, including hypercholesterolemia, atherosclerosis, myocardial infarction, heart failure, type 2 diabetes mellitus, obesity, have expanded. As probiotics, lactobacilli occupy a substantial part GM play important roles through various GM-derived metabolites. Lactobacilli ultimately impact on lipid metabolism, inflammatory factors, oxidative stress relieve symptoms However, axis cellular process commensal improving not been fully elucidated. Additionally, strains produce diverse antimicrobial peptides, which help maintain intestinal homeostasis ameliorate These field needs further investigated immediately. Thus, this review demonstrated mechanisms summarized evidence benefit strain supplementation from animal studies human clinical trials. We also highlighted broad range candidates therapeutic capability mining their Our study provides instruction as food improve
Язык: Английский
Процитировано
60
mSystems, Год журнала: 2022, Номер 7(2)
Опубликована: Март 28, 2022
Despite recent advances in therapeutic strategies and drug treatments (e.g., statins) for coronary artery disease (CAD), CAD-related mortality morbidity remain high. Active bidirectional interactions between the gut microbiota heart implicate that probiotic application could be a novel strategy CAD.
Язык: Английский
Процитировано
59
Pharmacological Research, Год журнала: 2023, Номер 192, С. 106799 - 106799
Опубликована: Май 19, 2023
Depression is the most prevalent mental disorder in world associated with huge socio-economic consequences. While depressive-related symptoms are well known, molecular mechanisms underlying disease pathophysiology and progression remain largely unknown. The gut microbiota (GM) emerging as a key regulator of central nervous system homeostasis by exerting fundamental immune metabolic functions. In turn, brain influences intestinal microbial composition through neuroendocrine signals, within so-called microbiota-brain axis. balance this bidirectional crosstalk important to ensure neurogenesis, preserve integrity blood-brain barrier avoid neuroinflammation. Conversely, dysbiosis permeability negatively affect development, behavior, cognition. Furthermore, although not fully defined yet, changes GM depressed patients reported influence pharmacokinetics common antidepressants affecting their absorption, metabolism, activity. Similarly, neuropsychiatric drugs may shape turn an impact on efficacy toxicity pharmacological intervention itself. Consequently, strategies aimed at re-establishing correct homeostatic (i.e., prebiotics, probiotics, fecal transplantation, dietary interventions) represent innovative approach improve pharmacotherapy depression. Among these, probiotics Mediterranean diet, alone or combination standard care, hold promise for clinical application. Therefore, disclosure intricate network between depression will give precious insights diagnostic therapeutic approaches towards depression, profound implications drug development practice.
Язык: Английский
Процитировано
39
Frontiers in Neuroscience, Год журнала: 2023, Номер 16
Опубликована: Фев. 6, 2023
Preliminary evidence supports the use of dietary interventions and gut microbiota-targeted such as probiotic or prebiotic supplementation for improving mental health. We report on first randomised controlled trial (RCT) to examine effects a high-prebiotic intervention supplements health."Gut Feelings" was an 8-week, 2 × factorial RCT 119 adults with moderate psychological distress low food intake. Treatment arms: (1) supplement diet-as-usual (probiotic group); (2) diet placebo (prebiotic (3) (synbiotic (4) (placebo group). The primary outcome assessment total mood disturbance (TMD; Profile Mood States Short Form) from baseline 8 weeks. Secondary outcomes included anxiety, depression, stress, sleep, wellbeing measures.A modified intention-to-treat analysis using linear mixed models revealed that reduced TMD relative at weeks [Cohen's d = -0.60, 95% confidence interval (CI) -1.18, -0.03; p 0.039]. There no symptom improvement (d -0.19, CI -0.75, 0.38; 0.51) synbiotic treatments -0.03, -0.59, 0.53; 0.92). Improved sleep were noted in response while tentatively improved wellbeing, placebo. No benefit found intervention. All well tolerated few adverse events.A may improve mood, A combination does not appear have beneficial effect health outcomes, though further is required. Results are limited by relatively small sample size.https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372753, identifier ACTRN12617000795392.
Язык: Английский
Процитировано
38
Korean Circulation Journal, Год журнала: 2023, Номер 53(8), С. 499 - 499
Опубликована: Янв. 1, 2023
Cardiovascular diseases (CVDs), including coronary artery disease, stroke, heart failure, and hypertension, are the global leading causes of death, accounting for more than 30% deaths worldwide. Although risk factors CVDs have been well understood various treatment preventive measures established, mortality rate financial burden expected to grow exponentially over time due changes in lifestyles increasing life expectancies present generation. Recent advancements metagenomics metabolomics analysis identified gut microbiome its associated metabolites as potential CVDs, suggesting possibility developing effective novel therapeutic strategies against CVD. In addition, evidence has demonstrated alterations ratio Firmicutes Bacteroidetes imbalance microbial-dependent metabolites, short-chain fatty acids trimethylamine N-oxide, play a crucial role pathogenesis However, exact mechanism action remains undefined this day. review, we focus on compositional related CVDs. Moreover, targeting discussed.
Язык: Английский
Процитировано
28