Behavioural Brain Research, Год журнала: 2020, Номер 395, С. 112853 - 112853
Опубликована: Авг. 6, 2020
Язык: Английский
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2020, Номер 105, С. 110142 - 110142
Опубликована: Окт. 15, 2020
Psychobiotics are considered among potential avenues for modulating the bidirectional communication between gastrointestinal tract and central nervous system, defined as microbiota-gut-brain axis (MGBA). Even though causality has not yet been established, intestinal dysbiosis emerged a hallmark of several diseases, including neuropsychiatric disorders (NPDs). The fact that microbiota system co-developing during first years life provided paradigm suggesting role psychobiotics earlier interventions. Studies in animal models early-life stress (ELS) have shown they can counteract pervasive effects this crucial developmental period, rescue behavioral symptoms related to anxiety depression later life. In humans, evidence from clinical studies on efficacy at improving mental outcomes most NPDs remain limited, except major depressive disorder which more available. Consequently, beneficial effect depression-related adults becoming clearer. While specific mechanisms play elusive, generally involve hypothalamic-pituitary-adrenal axis, permeability, inflammation. It is anticipated future will explore mitigating risk developing vulnerable individuals or context childhood adversity. However, such challenging present terms design target populations; profound impact proper development MGBA year increasingly recognized, but trajectories post-ELS humans by affects susceptibility various still ill-defined. As likely exert both shared mechanisms, better definition subpopulations would allow tailor selection aligning mechanistic properties with known pathophysiological factors. Here we review available preclinical supporting ameliorating outcomes, highlighting knowledge gaps challenges associated conducting longitudinal address outstanding key questions field.
Язык: Английский
Процитировано
59
Probiotics and Antimicrobial Proteins, Год журнала: 2020, Номер 13(1), С. 12 - 18
Опубликована: Июнь 29, 2020
Язык: Английский
Процитировано
53
Clinical Nutrition ESPEN, Год журнала: 2021, Номер 45, С. 75 - 90
Опубликована: Авг. 8, 2021
Язык: Английский
Процитировано
51
Expert Review of Neurotherapeutics, Год журнала: 2021, Номер 21(3), С. 303 - 315
Опубликована: Янв. 25, 2021
Introduction: 'Nutritional Psychiatry' is an emerging area of research that has great potential as adjunctive tool for the prevention and treatment diverse neuropsychiatric disorders. Several nutrition-related aspects, such obesity, dietary patterns, gut microbiome composition permeability, bioactive food compounds, nutrients can influence pathways implicated in pathophysiology mood disorders.Areas covered: Here, authors review current evidence on nutrition–mood interaction nutrition-based treatments two main disorders, i.e., major depressive disorder bipolar disorder.Expert opinion: Consistent from observational studies pointed out association between a 'healthy' diet, generally characterized by higher intake fruits, vegetables, legumes, nuts, whole grains, good quality sources protein (i.e. fish and/or seafood), decreased risk disorders parallel 'Western' diet pattern increased risk. However, only few clinical trials have evaluated effect nutritional interventions these conditions. The bidirectional brain gut, named 'brain-gut-microbiome axis' or 'gut-brain axis', plays key role link nutrition Therefore, strategies microbiota modulation are promising fields
Язык: Английский
Процитировано
41
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Март 1, 2023
Relationship between drugs and microbiota is bilateral. Proper composition thus function of a key to some medications used in modern medicine. However, there also the other side coin. Pharmacotherapeutic agents can modify significantly, which consequently affects its function. A recently published study showed that nearly 25% administered humans have antimicrobial effects. Multiple antidepressants are antimicrobials,. antibiotics with proven antidepressant effects do exist. On hand, (e.g., isoniaside, minocycline) confer mental phenotype changes, adverse caused by include neurological psychological symptoms further supports hypothesis intestinal may affect central nervous system. Here we gathered comprehensively data on psychiatry regarding their properties. We believe our has strong implications for treatment psychiatric entities. Nevertheless ours highlights need more well-designed trials aimed at analysis gut
Язык: Английский
Процитировано
18
Frontiers in Neuroscience, Год журнала: 2023, Номер 17
Опубликована: Сен. 1, 2023
There are previous epidemiological studies reporting associations between antibiotic use and psychiatric symptoms. Antibiotic-induced gut dysbiosis alteration of microbiota-gut-brain axis communication has been proposed to play a role in this association. In systematic review meta-analysis, we reviewed published articles that have presented results on changes cognition, emotion, behavior rodents (rats mice) after antibiotic-induced dysbiosis. We searched three databases—PubMed, Web Science, SCOPUS identify such using dedicated search strings extracted data from 48 articles. Increase anxiety depression-like was reported 32.7 40.7 percent the study-populations, respectively. Decrease sociability, social novelty preference, recognition memory spatial cognition found 18.1, 35.3, 26.1, 62.5 Only one bacterial taxon (increase Proteobacteria ) showed statistically significant association with behavioral anxiety). were no consistent findings statistical significance for potential biomarkers [Brain-derived neurotrophic factor (BDNF) expression hippocampus, serum corticosterone circulating IL-6 IL-1β levels]. Results meta-analysis revealed symptoms negative valence system (including depression) cognitive (decreased cognition) intake ( p < 0.05). However, between-study heterogeneity publication bias Risk evaluated be high majority studies. identified discussed several reasons could contribute examined. The provide promising evidence there is indeed an psychopathologies. inconsistencies implemented methodologies make generalizing these difficult. Gut microbiota depletion antibiotics may useful strategy evaluate if how microbes influence behavior, but used precludes any definitive interpretations translational impact clinical practice.
Язык: Английский
Процитировано
17
Biological Trace Element Research, Год журнала: 2021, Номер 199(12), С. 4430 - 4438
Опубликована: Янв. 6, 2021
Язык: Английский
Процитировано
33
European Journal of Nutrition, Год журнала: 2022, Номер unknown
Опубликована: Окт. 14, 2022
Abstract Purpose Probiotics or synbiotics consumption have been suggested to reduce the risk of cardiovascular disease (CVD) through a decline in inflammation and oxidative stress, however, results from studies are conflicting. This study filled this knowledge gap by evaluating randomized controlled trials (RCTs) investigating probiotics intake on adipokines, inflammation, stress patients with prediabetes type-2 diabetes mellitus (T2DM). Methods We systematically did search up March 2022 PubMed/Medline, Scopus, ISI Web Science, Cochrane library. A random-effect model was applied estimate weighted mean difference (WMD) 95% confidence interval (95% CI) for each outcome. Results total 32 RCTs were included meta-analysis. intervention led significant decrease levels C-reactive protein (CRP) (WMD − 0.62 mg/l; CI 0.80, 0.44; p < 0.001), tumor necrosis factor-α (TNF-α) 0.27 pg/ml; 0.44, 0.10; = 0.002) malondialdehyde (MDA) 0.51 µmol/l; 0.73, 0.30; also increase glutathione (GSH) 69.80 33.65, 105.95; antioxidant capacity (TAC) 73.59 mmol/l; 33.24, 113.95; 0.001) nitric oxide (NO) 7.49 3.12, 11.86; without alterations interleukin-6 (IL-6) adipokines levels. Conclusion could be useful improve cardiometabolic outcomes reduced T2DM.
Язык: Английский
Процитировано
27
Frontiers in Psychiatry, Год журнала: 2022, Номер 13
Опубликована: Июнь 9, 2022
Depression is the major cause of disability globally. Apart from lowered mood and accompanying symptoms, it leads to cognitive impairment that altogether predicts disadvantaged social functioning. Reduced function in depression appears a bit neglected field clinical molecular psychiatry, while estimated occur two-thirds depressed patients persist at least one third remitted patients. This problem, therefore, requires elucidation biomolecular system levels calls for improvement therapeutic approach. In this review study, we address above-mentioned issues by discussing putative mechanisms decline depression: (1) increased oxidative stress (2) inflammation, (3) disturbed hypothalamus-pituitary-adrenals axis, (4) reduced monoamines functionality. Moreover, acknowledge additional underpinnings elderly: (5) vascular-originated brain ischemia (6) amyloid-beta plaque accumulation. Additionally, reviewing molecular, pre-clinical evidence, propose gut microbiota-targeted strategies as potential adjuvant therapeutics. The study provides consolidated source knowledge regarding may path way toward improved treatment options.
Язык: Английский
Процитировано
25
Frontiers in Nutrition, Год журнала: 2022, Номер 9
Опубликована: Сен. 28, 2022
The co-occurrence of obesity and mood impairments named as "metabolic syndrome" (MMS) is often neglected in the management. This study aimed to evaluate effects Probio-Tec ®BG-VCap-6.5 magnesium co-supplementation on mood, cognition, intestinal barrier function serum C reactive protein (CRP) levels participants with depressed mood.Seventy-four eligible were randomly allocated either Probio-Tec®BG-VCap-6.5 [containing Lactobacillus rhamnosus (LGG®) Bifidobacterium animalis subsp. Lactis (BB-12®)] + Magnesium chloride or placebo for 9 weeks. Sociodemographic data collected beginning. Anthropometric, dietary physical activity (PA) assessments carried out. Beck Depression Inventory-II (BDI-II) Montreal Cognitive Assessment (MoCA) scores assessed through validated questionnaires. Fasting plasma zonulin, lipopolysaccharide (LPS) measured by ELIZA kits.Of seventy-four (mean age 37.51 ± 8.10), 52 completed study. Changes LPS zonulin not different significantly between groups (-3.04 44.75 ng/dl, 0.11 5.13, p > 0.05 1.40 48.78 -0.17 6.60, respectively). CRP reduced intervention group compared [-474.75 (-1,300.00, -125.00) mg/l vs. 175.20 (-957.75, 1,683.25) mg/l, = 0.016]. BDI-II MoCA (-7.13 5.67, 1.20 2.16, respectively) (-5.42 6.71, 1.94 1.86, (p 0.05).Nine weeks probiotic resulted decreased an indicator inflammatory state no significant cognition integrity individuals mood.
Язык: Английский
Процитировано
23