Clinical & Experimental Metastasis,
Год журнала:
2023,
Номер
40(3), С. 217 - 226
Опубликована: Май 23, 2023
Brain
metastases
(BM)
in
patients
with
thyroid
cancer
(TC)
are
rare
an
incidence
of
1%
for
papillary
and
follicular,
3%
medullary
up
to
10%
anaplastic
TC
(PTC,
FTC,
MTC
ATC).
Little
is
known
about
the
characteristics
management
BM
from
TC.
Thus,
we
retrospectively
analyzed
histologically
verified
radiologically
identified
Vienna
Metastasis
Registry.
A
total
20/6074
included
database
since
1986
had
13/20
were
female.
Ten
8
PTC,
one
ATC.
The
median
age
at
diagnosis
was
68
years.
All
but
symptomatic
a
singular
BM.
Synchronous
primary
found
6
patients,
while
time
13
years
PTC
(range
1.9-24),
4
FTC
2.1-41)
22
patient.
overall
survival
months
1.8-57),
26
3.9-188),
12
3
ATC
In
conclusion,
development
exceedingly
most
common
presentation
single
lesion.
While
generally
constitute
poor
prognostic
factor,
individual
experience
long-term
following
local
therapy.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 12, 2024
Abstract
Cancer
treatment
faces
many
hurdles
and
resistance
is
one
among
them.
Anti-cancer
strategies
are
evolving
due
to
innate
acquired
capacity,
governed
by
genetic,
epigenetic,
proteomic,
metabolic,
or
microenvironmental
cues
that
ultimately
enable
selected
cancer
cells
survive
progress
under
unfavorable
conditions.
Although
the
mechanism
of
drug
being
widely
studied
generate
new
target-based
drugs
with
better
potency
than
existing
ones.
However,
broader
flexibility
in
resistance,
advanced
therapeutic
options
efficacy
need
be
explored.
Combination
therapy
an
alternative
a
success
rate
though
risk
amplified
side
effects
commonplace.
Moreover,
recent
groundbreaking
precision
immune
ways
overcome
has
revolutionized
anticancer
greater
extent
only
limitation
individual-specific
needs
further
attention.
This
review
will
focus
on
challenges
opted
withstand
current
therapies
at
molecular
level
also
highlights
emerging
-like
immunological,
stem
cell-based
may
prove
have
potential
challenge
problem
resistance.
Best Practice & Research Clinical Endocrinology & Metabolism,
Год журнала:
2022,
Номер
37(1), С. 101687 - 101687
Опубликована: Авг. 12, 2022
Differentiated
thyroid
carcinoma
(DTC)
is
the
most
common
endocrine
cancer.
Particularly
incidence
of
small
clinically
indolent
tumors
has
been
increasing
significantly
during
last
decades
because
increased
diagnostic
scrutiny,
while
DTC-related
mortality
remained
unchanged.
In
light
awareness
significant
risk
detecting
and
potential
harm
burden
associated
with
overly
diagnosis
treatment,
approach
towards
management
DTC
recently
underwent
a
critical
appraisal.
The
focus
lays
on
reducing
unnecessary
for
patients
very
low
correct
identification
those
who
require
treatment
that
more
intensive
and/or
follow-up.
Management
includes
range
different
modalities,
making
multidisciplinary
collaboration
expedient.
this
review,
we
elaborate
recent
developments
in
diagnosis,
staging
specific
individualized
assessment-based
approach.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Март 4, 2024
Driven
by
the
intricacy
of
illness
and
need
for
individualized
treatments,
targeted
therapy
biomarker
research
in
thyroid
cancer
represent
an
important
frontier
oncology.
The
variety
genetic
changes
associated
with
demand
more
investigation
to
elucidate
molecular
details.
This
is
clinically
significant
since
it
can
be
used
develop
customized
treatment
plans.
A
focused
approach
provided
therapies,
which
target
certain
targets
such
as
mutant
BRAF
or
RET
proteins.
strategy
minimizes
collateral
harm
healthy
tissues
may
also
reduce
adverse
effects.
Simultaneously,
patient
categorization
based
on
profiles
made
possible
exploration,
allows
regimens
maximizes
therapeutic
results.
benefits
go
beyond
their
immediate
clinical
impact
encompass
whole
landscape.
Comprehending
underpinnings
facilitates
creation
novel
treatments
that
specifically
aberrant
molecules.
advances
precision
medicine,
paving
way
other
cancers.
Taken
simply,
study
promising
better
care.
concepts
discovered
during
this
have
potential
completely
transform
care
provided,
bringing
a
new
era
personalized,
medicine.
paradigm
shift
could
improve
prognosis
quality
life
individuals
act
inspiration
types.
Biomedicines,
Год журнала:
2024,
Номер
12(3), С. 502 - 502
Опубликована: Фев. 23, 2024
The
fact
that
the
Mediterranean
diet
could
represent
a
source
of
natural
compounds
with
cancer-preventive
and
therapeutic
activity
has
been
object
great
interest,
especially
regard
to
mechanisms
action
polyphenols
found
in
olive
oil
leaves.
Secoiridoid
oleuropein
(OLE)
its
derivative
hydroxytyrosol
(3,4-dihydroxyphenylethanol,
HT)
have
demonstrated
anti-proliferative
properties
against
variety
tumors
hematological
malignancies
both
vivo
vitro,
measurable
effects
on
cellular
redox
status,
metabolism,
transcriptional
activity.
With
this
review,
we
aim
summarize
most
up-to-date
information
potential
use
OLE
HT
for
cancer
treatment,
making
important
considerations
about
bioavailability,
OLE-
HT-mediated
drug
dual
as
pro-
antioxidants,
likely
hampering
their
clinical
routine.
Also,
focus
details
available
nutritionally
relevant
concentrations
cell
viability,
homeostasis,
inflammation
order
evaluate
if
be
considered
agents
or
new
chemotherapy
drugs
whenever
only
is
represented
by
diet.
Endocrine Pathology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 23, 2024
Thyroid
cancer
management
is
rapidly
changing.
The
identification
of
actionable
biomarkers
through
both
germline
and
somatic
testing
are
now
an
integral
part
directing
patient
management.
However,
deficiencies
disparities
within
existing
thyroid
biomarker
test
approaches
resulting
in
inconsistent
application
for
care.
An
expert
panel
was
convened
to
create
consensus
algorithms
recommendations
on
patients
diagnosed
with
medullary
cancer,
non-anaplastic
follicular
cell-derived
or
anaplastic
who
may
benefit
from
targeted
therapies.
A
review
international
guidelines
performed
determine
the
current
state,
a
literature
carried
out
further
evaluate
evidence
supporting
use
cancer.
biomarker-related
gaps
impacting
care
were
also
discussed,
emphasis
importance
multidisciplinary
team
approach
optimal
presented
aim
help
physicians
navigate
landscape
its
many
challenges,
balancing
aspirational
what
practical
feasible
terms
economic
realities
jurisdictional
constraints.
By
remaining
therapy-agnostic,
these
broadly
applicable.
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 5, 2022
Immunotherapy
has
changed
the
treatment
of
patients
with
advanced
cancer,
different
phase
III
trials
showing
durable
responses
across
histologies.
This
review
focuses
on
preclinical
and
clinical
evidence
potential
predictive
biomarkers
response
efficacy
immunotherapy
in
thyroid
neoplasms.
Programmed
death-ligand
1
(PD-L1)
staining
by
immunohistochemistry
shown
higher
expression
anaplastic
cancer
(ATC)
compared
to
other
subtypes.
The
tumor
mutational
burden
neoplasms
is
low
but
seems
be
ATC.
Immune
infiltrates
microenvironment
(TME)
differ
between
neoplasm
In
general,
differentiated
(DTC)
a
number
tumor-associated
lymphocytes
regulatory
T
cells
(Tregs),
while
ATC
medullary
(MTC)
display
high
density
macrophages
(TAMs).
Nevertheless,
results
from
as
monotherapy
or
combinations
have
limited
efficacy.
Further
investigation
into
new
strategies
aside
anti-cytotoxic
T-lymphocyte
antigen
4
(CTLA-4)/programmed
death
(PD-1)/PD-L1
antibodies,
validation
biomarkers,
better
population
selection
for
more
than
needed
near
future.
Analytical Sciences,
Год журнала:
2024,
Номер
40(7), С. 1225 - 1237
Опубликована: Апрель 12, 2024
The
escalating
threat
of
emerging
diseases,
often
stemming
from
contaminants
and
lethal
pathogens,
has
precipitated
a
heightened
demand
for
sophisticated
diagnostic
tools.
Within
this
landscape,
the
functional
nucleic
acid
(FNA)
biosensor,
harnessing
power
single-stranded
DNA
(ssDNA),
emerged
as
preeminent
choice
target
analyte
detection.
However,
dependence
on
ssDNA
raised
difficulties
in
realizing
it
biological
samples.
Therefore,
production
high-quality
samples
is
critical.
This
review
aims
to
discuss
strategies
generating
integration
into
biosensors.
Several
innovative
generation
have
been
deployed,
encompassing
techniques,
such
asymmetric
PCR,
Exonuclease-PCR,
isothermal
amplification,
biotin–streptavidin
transcription-reverse
transcription,
overhang
generation,
urea
denaturation
PAGE.
These
approaches
seamlessly
integrated
with
biosensors
sample
analysis,
ushering
new
era
disease
detection
monitoring.
amalgamation
techniques
biosensing
applications
holds
significant
promise,
not
only
improving
speed
accuracy
processes
but
also
fortifying
global
response
deadly
thereby
underlining
pivotal
role
cutting-edge
biotechnology
public
health
prevention.
Endocrine Pathology,
Год журнала:
2024,
Номер
35(4), С. 372 - 384
Опубликована: Ноя. 19, 2024
Abstract
Formalin-fixed
paraffin-embedded
(FFPE)
tissue
samples
are
important
for
genomic
analysis
of
thyroid
carcinomas,
particularly
various
molecularly
targeted
therapies.
Therefore,
this
study
developed
and
validated
a
technique
preparing
FFPE
that
preserves
nucleic
acid
quality,
which
is
fundamental
precise
analysis,
more
effectively
than
conventional
methods.
We
analyzed
surgically
resected
gland
tumors,
lymph
node
metastases,
separately
fixed
tumor
to
optimize
formalin
fixation
assess
the
influence
specimen
type
preparation
methods
on
quality.
assessed
several
quality
indicators,
including
DNA
integrity
number,
cycle
threshold
ratio,
RNA
DV200.
Separately
consistently
exhibited
higher
conventionally
processed
samples.
Additionally,
metastases
often
exhibit
matching
or
exceeding
highlighting
their
potential
reliability
analysis.
These
findings
suggest
utility
types
comprehensive
genetic
profiling
carcinomas.
In
conclusion,
demonstrated
an
effective
method
preserving
analyses.
Biopsy
punches
enable
collection
at
facilities,
those
without
ability
handle
frozen
specimens.
This
contributes
development
obtaining
high-quality
pathological
can
be
widely
used
in
general
medical
practice.
Moreover,
equal
superior
as
acceptable
sources
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 28, 2025
Programmed
cell
death
(PCD)
is
a
vital
biological
process
that
essential
for
regulating
progression
and
tumor
microenvironment.
This
study
aimed
to
explore
the
relationship
between
PCD-related
genes
expression
prognosis
in
thyroid
cancer
(THCA),
especially
IL20RA,
as
potential
prognostic
marker
THCA.
Data
from
The
Cancer
Genome
Atlas
(TCGA)
database
was
utilized
develop
risk
prediction
model
based
on
LASSO
regression
along
with
univariate
Cox
regression.
correlation
immune
infiltration
also
assessed.
value
of
key
gene
THCA
investigated
by
immunohistochemistry.
regulatory
function
PCD
related
molecules
were
detected
cellular
experiments.
We
identified
four
(NPC2,
E2F1,
TREM2)
constructed
exhibited
excellent
accuracy
predicting
Moreover,
we
confirmed
high
IL20RA
poor
promoted
proliferation
knockdown
increased
apoptosis
ferroptosis.
Analysis
microenvironment
detection
macrophages
polarization
showed
M2
while
reducing
M1.
several
genes.
which
could
potentially
provide
foundation
additional
investigations
into
diagnostic
markers
treatment
targets
