Cell, Год журнала: 2012, Номер 148(4), С. 765 - 779
Опубликована: Фев. 1, 2012
Язык: Английский
Annual Review of Physiology, Год журнала: 2010, Номер 72(1), С. 551 - 577
Опубликована: Фев. 11, 2010
The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals. Individual SCN neurons dispersed culture can generate independent oscillations of clock gene expression and neuronal firing. However, rhythmicity depends on sufficient membrane depolarization levels intracellular calcium cAMP. In intact SCN, cellular are synchronized reinforced by rhythmic synaptic input from other cells, resulting a reproducible topographic pattern distinct phases amplitudes specified circuit organization. network synchronizes its component oscillators, reinforces their oscillations, responds to light altering phase distribution, increases robustness genetic perturbations, enhances precision. Thus, even though individual be cell-autonomous properties integral normal function SCN.
Язык: Английский
Процитировано
1131
Cell, Год журнала: 2014, Номер 157(1), С. 187 - 200
Опубликована: Март 1, 2014
Язык: Английский
Процитировано
597
Neuron, Год журнала: 2014, Номер 84(1), С. 18 - 31
Опубликована: Окт. 1, 2014
Язык: Английский
Процитировано
480
Progress in Neurobiology, Год журнала: 2010, Номер 92(1), С. 42 - 104
Опубликована: Май 5, 2010
Язык: Английский
Процитировано
477
Annual Review of Physiology, Год журнала: 2010, Номер 72(1), С. 605 - 624
Опубликована: Фев. 11, 2010
Circadian clocks organize behavior and physiology to adapt daily environmental cycles. Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely conserved molecular gears of these 24-h timers. Yet much less is known about how cell-autonomous confer temporal information modulate cellular functions. Here we discuss our current knowledge circadian clock function Drosophila, providing an overview underpinnings clocks. We then describe neural network important for rhythms locomotor activity, including might influence neuronal function. Finally, address a range behaviors physiological systems regulated by clocks, discussion specific peripheral oscillators key effectors where they been described. These studies reveal remarkable complexity pathways this "simple" model organism.
Язык: Английский
Процитировано
432
Cell, Год журнала: 2011, Номер 146(2), С. 194 - 207
Опубликована: Июль 1, 2011
Язык: Английский
Процитировано
389
Progress in Neurobiology, Год журнала: 2019, Номер 179, С. 101607 - 101607
Опубликована: Март 22, 2019
Язык: Английский
Процитировано
307
Annual Review of Genetics, Год журнала: 2010, Номер 44(1), С. 419 - 444
Опубликована: Ноя. 3, 2010
An internal time-keeping mechanism has been observed in almost every organism studied from archaea to humans. This circadian clock provides a competitive advantage fitness and survival ( 18, 30, 95, 129, 137 ). Researchers have uncovered the molecular composition of this by combining enzymology, biology, genetics, modeling approaches. However, understanding mechanistic link between output responses elusive. In three model organisms, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, whole-genome expression arrays enabled researchers investigate how maintaining connects an adaptive advantage. Here, we review impacts transcriptomics had on our with system-level responses. We explore discoveries made possible high-throughput RNA assays, network approaches used these large transcript datasets, potential future directions.
Язык: Английский
Процитировано
298
Peptides, Год журнала: 2011, Номер 32(6), С. 1335 - 1355
Опубликована: Март 31, 2011
Язык: Английский
Процитировано
283
Cell, Год журнала: 2013, Номер 154(4), С. 904 - 913
Опубликована: Авг. 1, 2013
Язык: Английский
Процитировано
259