Neuropeptide Transmission in Brain Circuits

Neuron, Год журнала: 2012, Номер 76(1), С. 98 - 115

Опубликована: Окт. 1, 2012

Язык: Английский

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Circadian Rhythms and Sleep in Drosophila melanogaster

Genetics, Год журнала: 2017, Номер 205(4), С. 1373 - 1397

Опубликована: Март 30, 2017

The advantages of the model organism Drosophila melanogaster, including low genetic redundancy, functional simplicity, and ability to conduct large-scale screens, have been essential for understanding molecular nature circadian (∼24 hr) rhythms, continue be valuable in discovering novel regulators rhythms sleep. In this review, we discuss current these interrelated biological processes wider implications research. Clock genes period timeless were first discovered screens developed 1970s. Feedback on their own transcription forms core clock, accurately timed expression, localization, post-transcriptional modification, function is thought critical maintaining cycle. Regulators, several phosphatases kinases, act different steps feedback loop ensure strong rhythms. Approximately 150 neurons fly brain that contain components clock together translate intracellular cycling into rhythmic behavior. We how groups serve functions allowing clocks entrain environmental cues, driving behavioral outputs at times day, flexible responses conditions. neuropeptide PDF provides an important signal synchronize neurons, although details accomplishes are still being explored. Secreted signals from also influence other tissues. SLEEP is, part, regulated by which ensures appropriate timing sleep, but amount quality sleep determined mechanisms a homeostatic balance between wake. Flies useful identifying large set genes, molecules, neuroanatomic loci regulating amount. Conserved aspects regulation flies mammals include wake-promoting roles catecholamine neurotransmitters involvement hypothalamus-like regions, regions implicated less clear parallels. Sleep subject factors such as food availability, stress, social environment. beginning understand identified molecules interact with each other, environment, regulate researchers can take advantage increasing mechanistic behaviors, learning memory, courtship, aggression, loss impacts behaviors. thus remain tool both discovery deep

Язык: Английский

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Molecular Genetic Analysis of Circadian Timekeeping in Drosophila

Advances in genetics, Год журнала: 2011, Номер unknown, С. 141 - 173

Опубликована: Янв. 1, 2011

Язык: Английский

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Circadian neuron feedback controls the Drosophila sleep–activity profile

Nature, Год журнала: 2016, Номер 536(7616), С. 292 - 297

Опубликована: Авг. 1, 2016

Язык: Английский

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Unexpected features of Drosophila circadian behavioural rhythms under natural conditions

Nature, Год журнала: 2012, Номер 484(7394), С. 371 - 375

Опубликована: Апрель 1, 2012

Язык: Английский

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Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila

Cell, Год журнала: 2014, Номер 157(3), С. 689 - 701

Опубликована: Апрель 1, 2014

Язык: Английский

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A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability

Cell, Год журнала: 2015, Номер 162(4), С. 836 - 848

Опубликована: Авг. 1, 2015

Язык: Английский

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Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila

Current Biology, Год журнала: 2014, Номер 24(22), С. 2652 - 2664

Опубликована: Окт. 30, 2014

Язык: Английский

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The Drosophila Circadian Clock Is a Variably Coupled Network of Multiple Peptidergic Units

Science, Год журнала: 2014, Номер 343(6178), С. 1516 - 1520

Опубликована: Март 27, 2014

Circadian Rhythms rhythms in the fruit fly Drosophila are driven by neurons brain. Yao and Shafer (p. 1516 ) analyzed different sets of that can drive circadian rhythms. Manipulating period each set separately revealed when various clock signals were fairly consistent, showed a robust rhythm. But seriously out sync with one another, was oblivious to day-night cycle.

Язык: Английский

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A Circadian Output Circuit Controls Sleep-Wake Arousal in Drosophila

Neuron, Год журнала: 2018, Номер 100(3), С. 624 - 635.e4

Опубликована: Сен. 27, 2018

Язык: Английский

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