A functionally ordered visual feature map in the Drosophila brain

Neuron, Год журнала: 2022, Номер 110(10), С. 1700 - 1711.e6

Опубликована: Март 14, 2022

Topographic maps, the systematic spatial ordering of neurons by response tuning, are common across species. In Drosophila, lobula columnar (LC) neuron types project from optic lobe to central brain, where each forms a glomerulus in distinct position. However, advantages this glomerular arrangement unclear. Here, we examine functional and relationships 10 glomeruli using single-neuron calcium imaging. We discover novel detectors for objects smaller than lens resolution (LC18) complex line motion (LC25). find that spatially clustered selectivity looming versus drifting object ordered size tuning form topographic visual feature map. Furthermore, connectome analysis shows downstream integrate sparse subsets possible combinations, which biased encoding similar features. LC thus an explicit example topographically organized facilitate circuit integration.

Язык: Английский

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Visual processing in the fly, from photoreceptors to behavior

Genetics, Год журнала: 2023, Номер 224(2)

Опубликована: Май 2, 2023

Abstract Originally a genetic model organism, the experimental use of Drosophila melanogaster has grown to include quantitative behavioral analyses, sophisticated perturbations neuronal function, and detailed sensory physiology. A highlight these developments can be seen in context vision, where pioneering studies have uncovered fundamental generalizable principles processing. Here we begin with an overview vision-guided behaviors common methods for probing visual circuits. We then outline anatomy physiology brain regions involved processing, beginning at periphery ending descending motor control. Areas focus contrast motion detection optic lobe, circuits feature selectivity, computations support spatial navigation, contextual associative learning. Finally, look future fly neuroscience discuss promising topics further study.

Язык: Английский

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Social state gates vision using three circuit mechanisms inDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 17, 2024

Abstract Animals are often bombarded with visual information and must prioritize specific features based on their current needs. The neuronal circuits that detect relay have been well-studied. Yet, much less is known about how an animal adjusts its attention as goals or environmental conditions change. During social behaviors, flies need to focus nearby flies. Here, we study the flow of altered when female Drosophila enter aggressive state. From connectome, identified three state-dependent circuit motifs poised selectively amplify response fly-sized objects: convergence excitatory inputs from neurons conveying select internal state; dendritic disinhibition feature detectors; a switch toggles between two detectors. Using cell-type-specific genetic tools, together behavioral neurophysiological analyses, show each these function during aggression. We reveal this same operate in males courtship pursuit, suggesting disparate behaviors may share mechanisms. Our work provides compelling example using connectome infer mechanisms underlie dynamic processing sensory signals.

Язык: Английский

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Mapping model units to visual neurons reveals population code for social behaviour

Nature, Год журнала: 2024, Номер 629(8014), С. 1100 - 1108

Опубликована: Май 22, 2024

Abstract The rich variety of behaviours observed in animals arises through the interplay between sensory processing and motor control. To understand these sensorimotor transformations, it is useful to build models that predict not only neural responses input 1–5 but also how each neuron causally contributes behaviour 6,7 . Here we demonstrate a novel modelling approach identify one-to-one mapping internal units deep network real neurons by predicting behavioural changes arise from systematic perturbations more than dozen neuronal cell types. A key ingredient introduce ‘knockout training’, which involves perturbing during training match experiments. We apply this model transformations Drosophila melanogaster males complex, visually guided social 8–11 visual projection at interface optic lobe central brain form set discrete channels 12 , prior work indicates channel encodes specific feature drive particular 13,14 Our reaches different conclusion: combinations neurons, including those involved non-social behaviours, male interactions with female, forming population code for behaviour. Overall, our framework consolidates effects elicited various into single, unified model, providing map stimulus type behaviour, enabling future incorporation wiring diagrams 15 model.

Язык: Английский

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Expressions of emotions across species

Current Opinion in Neurobiology, Год журнала: 2021, Номер 68, С. 57 - 66

Опубликована: Фев. 5, 2021

What are emotions and how should we study them? These questions give rise to ongoing controversy amongst scientists in the fields of neuroscience, psychology philosophy, have resulted different views on [1-6]. In this review, define as functional states that bear essential roles promoting survival thus emerged through evolution. Emotions trigger behavioral, somatic, hormonal, neurochemical reactions, referred expressions emotion. We discuss recent studies emotion expression across species highlight emerging common principles. argue detailed multidimensional analyses key develop biology-based definitions reveal their neuronal underpinnings.

Язык: Английский

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Neural mechanisms to exploit positional geometry for collision avoidance

Current Biology, Год журнала: 2022, Номер 32(11), С. 2357 - 2374.e6

Опубликована: Май 3, 2022

Язык: Английский

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Visual and motor signatures of locomotion dynamically shape a population code for feature detection in Drosophila

eLife, Год журнала: 2022, Номер 11

Опубликована: Окт. 27, 2022

Natural vision is dynamic: as an animal moves, its visual input changes dramatically. How can the system reliably extract local features from dominated by self-generated signals? In Drosophila , diverse are represented a group of projection neurons with distinct tuning properties. Here, we describe connectome-based volumetric imaging strategy to measure visually evoked neural activity across this population. We show that jointly population, and shared gain factor improves trial-to-trial coding fidelity. A subset these neurons, tuned small objects, modulated two independent signals associated self-movement, motor-related signal, motion signal rotation animal. These inputs adjust sensitivity feature detectors locomotor cycle, selectively reducing their during saccades restoring it intersaccadic intervals. This work reveals for reliable detection locomotion.

Язык: Английский

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Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 15, 2025

The Drosophila visual system is a powerful model to study the development of neural circuits. Lobula columnar neurons-LCNs are output neurons that encode features relevant natural behavior. There ~20 classes LCNs forming non-overlapping synaptic optic glomeruli in brain. To address their origin, we used single-cell mRNA sequencing define transcriptome LCN subtypes and identified lines expressed throughout development. We show originate from stem cells four distinct brain regions exhibiting different modes neurogenesis, including ventral dorsal tips outer proliferation center, superficial inner center central this convergence similar illustrates complexity generating neuronal diversity, likely reflects evolutionary origin each subtype detects specific feature might influence behaviors species. Here authors developmental origins Columnar Neurons brain, tracing them regions. highlights diversity.

Язык: Английский

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Columnar neurons support saccadic bar tracking in Drosophila

eLife, Год журнала: 2023, Номер 12

Опубликована: Апрель 4, 2023

Tracking visual objects while maintaining stable gaze is complicated by the different computational requirements for figure-ground discrimination, and distinct behaviors that these computations coordinate. Drosophila melanogaster uses smooth optomotor head body movements to stabilize gaze, impulsive saccades pursue elongated vertical bars. Directionally selective motion detectors T4 T5 cells provide inputs large-field neurons in lobula plate, which control stabilization behavior. Here, we hypothesized an anatomically parallel pathway represented T3 cells, lobula, drives bar tracking saccades. We combined physiological behavioral experiments show respond omnidirectionally same stimuli elicit saccades, silencing reduced frequency of optogenetic manipulation acted on saccade rate a push–pull manner. Manipulating did not affect responses motion. Our results neural pathways coordinate saccadic behavior during flight.

Язык: Английский

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Neural Circuit Mechanisms Involved in Animals’ Detection of and Response to Visual Threats

Neuroscience Bulletin, Год журнала: 2023, Номер 39(6), С. 994 - 1008

Опубликована: Янв. 25, 2023

Язык: Английский

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