Neural Circuits Underlying Behavioral Flexibility: Insights From Drosophila

Frontiers in Behavioral Neuroscience, Год журнала: 2022, Номер 15

Опубликована: Янв. 6, 2022

Behavioral flexibility is critical to survival. Animals must adapt their behavioral responses based on changes in the environmental context, internal state, or experience. Studies Drosophila melanogaster have provided insight into neural circuit mechanisms underlying flexibility. Here we discuss how behavior modulated by and learning. We describe general principles of organization modulation that underlie flexibility, are likely extend other species.

Язык: Английский

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A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) in Drosophila

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(9)

Опубликована: Фев. 23, 2024

Social enrichment or social isolation affects a range of innate behaviors, such as sex, aggression, and sleep, but whether there is shared mechanism not clear. Here, we report neural underlying modulation spontaneous locomotor activity (SoMo-SLA), an internal-driven behavior indicative internal states. We find that specifically reduces in male flies. identify neuropeptides Diuretic hormone 44 (DH44) Tachykinin (TK) to be up- down-regulated by necessary for SoMo-SLA. further demonstrate sexually dimorphic circuit, which the male-specific P1 neurons encoding states form positive feedback with interneurons coexpressing doublesex ( dsx ) Tk promote locomotion, while also negative DH44 inhibit locomotion. These two opposing neuromodulatory recurrent circuits represent potentially common underlies regulation multiple behaviors.

Язык: Английский

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A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in Drosophila

Science Advances, Год журнала: 2024, Номер 10(36)

Опубликована: Сен. 4, 2024

A-to-I RNA editing is a cellular mechanism that generates transcriptomic and proteomic diversity, which essential for neuronal immune functions. It involves the conversion of specific adenosines in molecules to inosines, are recognized as guanosines by machinery. Despite vast number sites observed across animal kingdom, pinpointing critical understanding their vivo functions remains challenging. Here, we study function an evolutionary conserved site Drosophila , located glutamate-gated chloride channel ( GluCl α). Our findings reveal flies lacking at this exhibit reduced olfactory responses odors impaired pheromone-dependent social interactions. Moreover, demonstrate crucial proper processing information projection neurons. results highlight value using conservation criterion identifying events with potential functional significance paves way elucidating intricate link between modification, physiology, behavior.

Язык: Английский

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Comparative perspectives on neuropeptide function and social isolation

Biological Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Lessons from lonely flies: Molecular and neuronal mechanisms underlying social isolation

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 156, С. 105504 - 105504

Опубликована: Дек. 6, 2023

Animals respond to changes in the environment which affect their internal state by adapting behaviors. Social isolation is a form of passive environmental stressor that alters animal behaviors across kingdom, including humans, rodents, and fruit flies. known increase violence, disrupt sleep depression leading poor mental physical health. Recent evidence from several model organisms suggests social leads remodeling transcriptional epigenetic landscape behavioral outcomes. In this review, we explore how manipulating experience fly Drosophila melanogaster can shed light on molecular neuronal mechanisms underlying driven We discuss recent advances made using powerful genetic toolkit assays uncover role neuromodulators, sensory modalities, pheromones, circuits mediating isolation. The insights gained these studies could be crucial for developing effective therapeutic interventions future.

Язык: Английский

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How Social Experience and Environment Impacts Behavioural Plasticity inDrosophila

Fly, Год журнала: 2021, Номер 16(1), С. 68 - 84

Опубликована: Дек. 2, 2021

An organism's behaviour is influenced by its social environment. Experiences such as isolation or crowding may have profound short long-term effects on an individual's behaviour. The composition of the environment also depends genetics and previous experiences individuals present, leading to additional potential outcomes from each interaction. In this article, we review selected literature related model organism Drosophila melanogaster, how respond variation in their throughout lifetimes. We focus behavioural phenotypes courtship, aggression, group dynamics, well other development physiology. consequences phenotypic plasticity due are discussed with respect ecology evolution Drosophila. relate these studies laboratory research practices involving animals.

Язык: Английский

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The social life of Drosophila melanogaster

Insectes Sociaux, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

Abstract In this review, we explore the social behavior of fruit fly Drosophila melanogaster , integrating mechanistic, ecological and evolutionary perspectives. Despite its status as a major laboratory model organism, D. ’s life remains generally underappreciated by biologists. Adult flies attract others to food sources through pheromone deposition, leading group formation. Within these groups, males engage in competitive reproductive behaviors while females adopt complex mating patterns lay eggs communally. Both sexes adapt their early well current experience. Communal egg-laying promotes larval formation, with larvae cooperating dig tunnels for protection breathing feeding. Aggregation is also visible at pupal stage, suggesting dimension entire cycle species. We examine cooperative considering context (resource distribution, predation, parasitism pressures, strategies) that influences interactions. discuss how individual physiology varies size diversity, potentially an adaptation costs benefits being group. This review underscores potential advancing research on interactions dynamics, demonstrating usefulness fields sociality, evolution neurosciences.

Язык: Английский

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Group-level differences in social network structure remain repeatable after accounting for environmental drivers

Royal Society Open Science, Год журнала: 2023, Номер 10(7)

Опубликована: Июль 1, 2023

Individuals show consistent between-individual behavioural variation when they interact with conspecifics or heterospecifics. Such patterns might underlie emergent group-specific and between-group differences. However, little is known about (i) how social non-social drivers (external drivers) shape group-level structures (ii) whether animal groups differences in structure after accounting for external drivers. We used automated tracking to quantify daily interactions association networks 12 colonies of zebra finches ( Taeniopygia guttata ). quantified the effects five (group size, group composition, ecological factors, physical environments methodological differences) on interaction tested expressed day-to-day network controlling these Overall, we found that contribute significantly structure. even contribution drivers, there remained significant support both (repeatability R : up 0.493) 0.736) structures. Our study demonstrates behaviour can be partitioned into different variation, contributions from factors.

Язык: Английский

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Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons

PLoS Genetics, Год журнала: 2024, Номер 20(1), С. e1011054 - e1011054

Опубликована: Янв. 18, 2024

Living in dynamic environments such as the social domain, where interaction with others determines reproductive success of individuals, requires ability to recognize opportunities obtain natural rewards and cope challenges that are associated achieving them. As such, actions promote survival reproduction reinforced by brain reward system, whereas coping obtaining these is mediated stress-response pathways, activation which can impair health shorten lifespan. While much research has been devoted understanding mechanisms underlying way processed less attention given consequences failure a desirable reward. model system study impact reward, we used well-established courtship suppression paradigm Drosophila melanogaster means induce repeated failures sexual male flies. We discovered beyond known reduction caused non-receptive females, mate stress response characterized persistent motivation reduced male-male interaction, enhanced aggression. This frustrative-like state conflict between high inability fulfill their mating drive impairs capacity rejected males tolerate stressors starvation oxidative stress. further show sensitivity arousal disinhibition small population neurons express receptors for fly homologue neuropeptide Y. Our findings demonstrate first time existence flies offers framework crosstalk stress, simple nervous highly amenable genetic manipulation.

Язык: Английский

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Genetically identical mice express alternative reproductive tactics depending on social conditions in the field

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 291(2019)

Опубликована: Март 20, 2024

In many species, establishing and maintaining a territory is critical to survival reproduction, an animal's ability do so strongly influenced by the presence density of competitors. Here we manipulate social conditions study alternative reproductive tactics displayed genetically identical, age-matched laboratory mice competing for territories under ecologically realistic environmental conditions. We introduced adult males females mouse strain C57BL/6J into large, outdoor field enclosure containing defendable resource zones one two first created low-density environment, such that number available exceeded males. After established stable territories, pulse intruder observed resulting defensive invasive employed. response this change in with large invested more patrolling but were less effective at excluding as compared small territories. Intruding failed establish tactic featuring greater exploration identical territorial Alternative did not lead equal success-males acquired experienced had access females.

Язык: Английский

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