Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

eLife, Год журнала: 2021, Номер 10

Опубликована: Дек. 16, 2021

Color and polarization provide complementary information about the world are detected by specialized photoreceptors. However, downstream neural circuits that process these distinct modalities incompletely understood in any animal. Using electron microscopy, we have systematically reconstructed synaptic targets of photoreceptors to detect color skylight Drosophila, used light microscopy confirm many our findings. We identified known novel selective for different wavelengths or polarized light, followed their projections other areas optic lobes central brain. Our results revealed synapses along photoreceptor axons between brain regions, new pathways lobes, spatially segregated regions. Strikingly, polarization-sensitive dorsal rim area target fewer cell types, lack strong connections lobula, a neuropil involved processing. reconstruction identifies shared wiring modality-specific specializations vision, provides comprehensive view first steps processing inputs.

Язык: Английский

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Visual processing in the fly, from photoreceptors to behavior

Genetics, Год журнала: 2023, Номер 224(2)

Опубликована: Май 2, 2023

Abstract Originally a genetic model organism, the experimental use of Drosophila melanogaster has grown to include quantitative behavioral analyses, sophisticated perturbations neuronal function, and detailed sensory physiology. A highlight these developments can be seen in context vision, where pioneering studies have uncovered fundamental generalizable principles processing. Here we begin with an overview vision-guided behaviors common methods for probing visual circuits. We then outline anatomy physiology brain regions involved processing, beginning at periphery ending descending motor control. Areas focus contrast motion detection optic lobe, circuits feature selectivity, computations support spatial navigation, contextual associative learning. Finally, look future fly neuroscience discuss promising topics further study.

Язык: Английский

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A single photoreceptor splits perception and entrainment by cotransmission

Nature, Год журнала: 2023, Номер 623(7987), С. 562 - 570

Опубликована: Окт. 25, 2023

Vision enables both image-forming perception, driven by a contrast-based pathway, and unconscious non-image-forming circadian photoentrainment, an irradiance-based pathway1,2. Although two distinct photoreceptor populations are specialized for each visual task3-6, photoreceptors can additionally contribute to photoentrainment of the clock in different species7-15. However, it is unknown how pathway functionally implement segregation irradiance signals required from contrast image perception. Here we report that Drosophila R8 separates co-transmitting neurotransmitters, histamine acetylcholine. This further established postsynaptically histamine-receptor-expressing unicolumnar retinotopic neurons acetylcholine-receptor-expressing multicolumnar integration neurons. The acetylcholine transmission sustained autocrine negative feedback cotransmitted during light phase light-dark cycles. At behavioural level, elimination impairs R8-driven motion detection respectively. Thus, single type achieve dichotomy perception as early first synapses, revealing simple yet robust mechanism segregate translate sensory features into animal behaviours.

Язык: Английский

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Different spectral sensitivities of ON- and OFF-motion pathways enhance the detection of approaching color objects in Drosophila

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Ноя. 24, 2023

Color and motion are used by many species to identify salient objects. They processed largely independently, but color contributes processing in humans, for example, enabling moving colored objects be detected when their luminance matches the background. Here, we demonstrate an unexpected, additional contribution of vision Drosophila. We show that behavioral ON-motion responses more sensitive UV than OFF-motion, cellular pathways connecting UV-sensitive R7 photoreceptors ON OFF-motion-sensitive T4 T5 cells, using neurogenetics calcium imaging. Remarkably, this circuitry enhances detection approaching discs, not green discs with same chromatic contrast, how could generalize systems ON- OFF-motion pathways. Our results provide a computational circuit basis favor saliently

Язык: Английский

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Hue selectivity from recurrent circuitry in Drosophila

Nature Neuroscience, Год журнала: 2024, Номер 27(6), С. 1137 - 1147

Опубликована: Май 16, 2024

In the perception of color, wavelengths light reflected off objects are transformed into derived quantities brightness, saturation and hue. Neurons responding selectively to hue have been reported in primate cortex, but it is unknown how their narrow tuning color space produced by upstream circuit mechanisms. We report discovery neurons Drosophila optic lobe with hue-selective properties, which enables circuit-level analysis processing. From our an electron microscopy volume a whole brain, we construct connectomics-constrained model that accounts for this selectivity. Our predicts recurrent connections critical generating Experiments using genetic manipulations perturb recurrence adult flies confirm prediction. findings reveal basis selectivity vision.

Язык: Английский

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Insect visual perception and pest control: opportunities and challenges

Current Opinion in Insect Science, Год журнала: 2025, Номер unknown, С. 101331 - 101331

Опубликована: Янв. 1, 2025

Humans and insects inhabit very different perceptual worlds, so human experimenters need to be aware of their biases when investigating insect behaviour. In applied entomology have been a barrier the rational design, manufacture, improvement pest control devices that effectively exploit visual This review describes how influence bias on this area is being reduced by our expanding understanding perception use modelling methods, highlights several important challenges are yet overcome.

Язык: Английский

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Connectome of the lamina reveals the circuit for early color processing in the visual pathway of a butterfly

Current Biology, Год журнала: 2022, Номер 32(10), С. 2291 - 2299.e3

Опубликована: Апрель 18, 2022

Язык: Английский

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Understanding the Tripartite Approach to Bayesian Divergence Time Estimation

Опубликована: Дек. 8, 2020

Placing evolutionary events in the context of geological time is a fundamental goal paleobiology and macroevolution. In this Element we describe tripartite model used for Bayesian estimation calibrated phylogenetic trees. The can be readily separated into its component models: substitution model, clock tree model. We provide an overview most widely models each highlight advantages implementing within framework.

Язык: Английский

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Neural mechanism of spatio-chromatic opponency in the Drosophila amacrine neurons

Current Biology, Год журнала: 2021, Номер 31(14), С. 3040 - 3052.e9

Опубликована: Май 24, 2021

Язык: Английский

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Achromatic Cues Are Important for Flower Visibility to Hawkmoths and Other Insects

Frontiers in Ecology and Evolution, Год журнала: 2022, Номер 10

Опубликована: Фев. 17, 2022

Studies on animal colour vision typically focus the chromatic aspect of colour, which is related to spectral distribution, and disregard achromatic aspect, intensity (“brightness”) a stimulus. Although component often most reliable for object recognition because it fairly context independent, may provide signal under specific conditions, example at night when light low. Here we make case importance cues in plant-pollinator signalling, based experimental data naïve Deilephila elpenor Macroglossum stellatarum hawkmoths, optical modelling synthesising published experiments bees, flies, butterflies moths. Our show that ecologically relevant levels hawkmoths express strong preference brighter stimuli. Published suggest flower-visiting butterflies, moths be more important detection than considered. enabled disentangling contribution pigments scattering structures flower’s contrast, illustrates how flower anatomy background are mediating factors. We discuss our findings often-assumed dichotomy between discrimination, versus vision, evolution floral visual signals.

Язык: Английский

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