Brain stimulation,
Год журнала:
2024,
Номер
17(1), С. 83 - 88
Опубликована: Янв. 1, 2024
No
study
on
neurostimulation
in
narcolepsy
is
available
until
now.
Arousal-
and
wake-promoting
effects
of
vagus
nerve
stimulation
(VNS)
have
been
demonstrated
animal
experiments
are
well-known
as
side
VNS
therapy
epilepsy
depression.
The
objective
was
to
evaluate
the
therapeutic
effect
daily
sleepiness
cataplexies
narcolepsy.
In
our
open-label
prospective
comparative
study,
we
included
patients
who
were
treated
with
because
depression
or
compared
them
controls
without
for
(18
each
group,
aged
31.5
±
8.2
years).
We
evaluated
(Epworth
Sleepiness
Scale,
ESS)
number
per
week
before
implantation
at
three
six
month
follow-ups.
Compared
baseline
(ESS:
15.9
2.5)
showed
a
significant
improvement
ESS
after
months
(11.2
3.3,
p
<
0.05)
(9.6
2.8,
0.001)
trend
reduction
cataplexies.
ESS-improvement
observed
(14.9
3.9,
13.6
3.7,
13.2
3.5,
=
0.2
baseline,
months,
correspondingly).
Side
did
not
differ
between
groups.
this
first
evaluation
narcolepsy,
found
due
type
neurostimulation.
could
be
promising
non-medical
treatment
Trends in Neurosciences,
Год журнала:
2023,
Номер
46(7), С. 508 - 524
Опубликована: Май 8, 2023
The
rapid
and
coordinated
propagation
of
neural
activity
across
the
brain
provides
foundation
for
complex
behavior
cognition.
Technical
advances
neuroscience
subfields
have
advanced
understanding
these
dynamics,
but
points
convergence
are
often
obscured
by
semantic
differences,
creating
silos
subfield-specific
findings.
In
this
review
we
describe
how
a
parsimonious
conceptualization
state
as
fundamental
building
block
whole-brain
offers
common
framework
to
relate
findings
scales
species.
We
present
examples
diverse
techniques
commonly
used
study
states
associated
with
physiology
higher-order
cognitive
processes,
discuss
integration
them
will
enable
more
comprehensive
mechanistic
characterization
dynamics
that
crucial
survival
disrupted
in
disease.
Brain stimulation,
Год журнала:
2024,
Номер
17(2), С. 233 - 244
Опубликована: Фев. 28, 2024
BackgroundTranscutaneous
auricular
vagus
nerve
stimulation
(tVNS
or
taVNS)
is
a
non-invasive
method
of
electrical
the
afferent
pathway
nerve,
suggested
to
drive
changes
in
putative
physiological
markers
noradrenergic
activity,
including
pupil
dilation.ObjectiveHowever,
it
unknown
whether
different
taVNS
modes
can
map
onto
phasic
and
tonic
activity.
The
effects
on
dilation
humans
are
inconsistent,
largely
due
differences
protocols.
Here,
we
attempted
address
these
issues.MethodsWe
investigated
under
(1
s)
(30
taVNS,
pre-registered,
single-blind,
sham-controlled,
within-subject
cross-over
design,
absence
behavioural
task.ResultsPhasic
induced
rapid
increase
size
over
baseline,
significantly
greater
than
sham
stimulation,
which
rapidly
declined
after
offset.
Tonic
similarly
(and
larger
sham)
returning
baseline
within
5
s,
despite
ongoing
stimulation.
Thus,
both
active
closely
resembled
effect.
There
were
no
size,
sustained
size.ConclusionsThese
results
suggest
that
phasic-
tonic-like
standard
parameters
may
modulate
primarily
mode
as
indexed
by
evoked
dilation,
above
somatosensory
effects.
This
result
sheds
light
temporal
profile
with
implications
for
their
applicability
further
research.
ABSTRACT
The
decline
in
noradrenergic
(NE)
locus
coeruleus
(LC)
function
aging
is
thought
to
be
implicated
episodic
memory
decline.
Transcutaneous
auricular
vagus
nerve
stimulation
(taVNS),
which
supports
LC
function,
might
serve
preserve
or
improve
aging.
However,
taVNS
effects
are
generally
very
heterogeneous,
and
it
currently
unclear
whether
has
an
effect
on
memory.
In
this
study,
emotional
task
with
negative
events
involving
the
LC‐NE
system
was
combined
short
burst
of
event‐related
(3
s)
younger
adults
(
N
=
24).
aim
investigate
taVNS‐induced
changes
pupil
dilation
during
encoding
possible
improvements
(emotional)
performance
for
early
delayed
(24
h)
recognition.
Negative
were
associated
increased
better
performance.
Additionally,
real
as
compared
sham
no
selectively
events.
Short
bursts
stimulation,
sham,
led
increase
improvement
over
time,
likely
due
attention‐inducing
sensory
modulation
electrical
stimulation.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(9), С. 5028 - 5028
Опубликована: Апрель 30, 2022
For
decades,
numerous
seminal
studies
have
built
our
understanding
of
the
locus
coeruleus
(LC),
vertebrate
brain’s
principal
noradrenergic
system.
Containing
a
numerically
small
but
broadly
efferent
cell
population,
LC
provides
brain-wide
modulation
that
optimizes
network
function
in
context
attentive
and
flexible
interaction
with
sensory
environment.
This
review
turns
attention
to
LC’s
roles
during
sleep.
We
show
these
go
beyond
down-scaled
versions
ones
wakefulness.
Novel
dynamic
assessments
noradrenaline
signaling
activity
uncover
rich
diversity
patterns
establish
as
an
integral
portion
sleep
regulation
function.
The
could
be
involved
beneficial
functions
for
sleeping
brain,
even
minute
alterations
its
functionality
may
prove
quintessential
disorders.
Brain Sciences,
Год журнала:
2023,
Номер
13(3), С. 451 - 451
Опубликована: Март 6, 2023
Characterized
by
high
morbidity,
mortality,
and
disability,
stroke
usually
causes
symptoms
of
cerebral
hypoxia
due
to
a
sudden
blockage
or
rupture
brain
vessels,
it
seriously
threatens
human
life
health.
Rehabilitation
is
the
essential
treatment
for
post-stroke
patients
suffering
from
functional
impairments,
through
which
hemiparesis,
aphasia,
dysphagia,
unilateral
neglect,
depression,
cognitive
dysfunction
can
be
restored
various
degrees.
Noninvasive
stimulation
(NIBS)
popular
neuromodulatory
technology
rehabilitation
focusing
on
local
cortex,
improve
clinical
functions
regulating
excitability
corresponding
neurons.
Increasing
evidence
has
been
obtained
application
NIBS,
especially
repetitive
transcranial
magnetic
(rTMS)
direct
current
(tDCS).
However,
without
standardized
protocol,
existing
studies
NIBS
show
wide
variation
in
terms
site,
frequency,
intensity,
dosage,
other
parameters.
Its
neurorehabilitation
still
limited.
With
advances
neuronavigation
technologies,
near-infrared
spectroscopy,
MRI,
specific
regions
precisely
located
stimulation.
On
basis
our
further
understanding
neural
circuits,
neuromodulation
also
evolved
single-target
co-stimulation
two
more
targets,
even
circuits
network.
The
present
study
aims
review
findings
research,
discuss
future
directions
application,
finally
promote
use
rehabilitation.
Brain stimulation,
Год журнала:
2023,
Номер
16(5), С. 1252 - 1258
Опубликована: Авг. 17, 2023
Vagus
nerve
stimulation
(VNS)
has
gained
enormous
traction
as
a
promising
bioelectronic
therapy.
In
particular,
the
delivery
of
VNS
paired
with
training
to
promote
neural
changes
demonstrated
clinical
success
for
stroke
recovery
and
found
far-reaching
application
in
other
domains,
from
autism
psychiatric
disorders
normal
learning.
The
been
extensively
documented.
Here,
we
consider
more
unusual
question:
why
does
have
such
broad
utility,
perhaps
importantly,
when
not
work?
We
present
discussion
concepts
that
underlie
therapy
an
anthology
studies
describe
conditions
which
these
are
violated
fails.
focus
specifically
on
mechanisms
engaged
by
implanted
VNS,
how
parameters
stimulation,
method,
pharmacological
manipulations,
accompanying
comorbidities,
specifics
concurrent
interact
impact
efficacy
As
is
increasing
translated
implementation,
clear
understanding
it
does,
critically,
work
fundamental
this
approach.
