DomeVR: Immersive virtual reality for primates and rodents DOI Creative Commons
Katharine A. Shapcott, Marvin Weigand,

Mina Glukhova

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0308848 - e0308848

Опубликована: Янв. 16, 2025

Immersive virtual reality (VR) environments are a powerful tool to explore cognitive processes ranging from memory and navigation visual processing decision making-and do so in naturalistic yet controlled setting. As such, they have been employed across different species, by diverse range of research groups. Unfortunately, designing implementing behavioral tasks such often proves complicated. To tackle this challenge, we created DomeVR, an immersive VR environment built using Unreal Engine 4 (UE4). UE4 is game engine supporting photo-realistic graphics containing scripting language designed for use non-programmers. result, easily drag-and-drop elements. DomeVR aims make these features accessible neuroscience experiments. This includes logging synchronization system solve timing uncertainties inherent UE4; interactive GUI scientists observe subjects during experiments adjust task parameters on the fly, dome projection full immersion non-human subjects. These key modular can be added individually into other projects. Finally, present proof-of-principle data highlighting functionality three species: human, macaque mouse.

Язык: Английский

Separating cognitive and motor processes in the behaving mouse DOI
Munib A. Hasnain, Jaclyn E Birnbaum,

Juan Luis Ugarte Nunez

и другие.

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Язык: Английский

Процитировано

1
Active vision during prey capture in wild marmoset monkeys DOI Creative Commons

Victoria Ngo,

Julia C. Gorman, María Fernanda De la Fuente

и другие.

Current Biology, Год журнала: 2022, Номер 32(15), С. 3423 - 3428.e3

Опубликована: Июнь 23, 2022

A foundational pressure in the evolution of all animals is ability to travel through world, inherently coupling sensory and motor systems. While this relationship has been explored several species,

Язык: Английский

Процитировано

31
Cross-modal representation of identity in the primate hippocampus DOI
Timothy J. Tyree, Michael Metke, Cory T. Miller

и другие.

Science, Год журнала: 2023, Номер 382(6669), С. 417 - 423

Опубликована: Окт. 26, 2023

Faces and voices are the dominant social signals used to recognize individuals among primates. Yet, it is not known how these integrated into a cross-modal representation of individual identity in primate brain. We discovered that, although single neurons marmoset hippocampus exhibited selective responses when presented with face or voice specific individual, parallel mechanism for representing identities multiple was evident within at population level. Manifold projections likewise showed separability as well clustering others' families, which suggests that learned categories encoded related dimensions hippocampus. Neural representations thus both modality independent reflect network.

Язык: Английский

Процитировано

17
Bioelectric control of locomotor gaits in the walking ciliate Euplotes DOI Creative Commons
Hannah Laeverenz-Schlogelhofer, Kirsty Y. Wan

Current Biology, Год журнала: 2024, Номер 34(4), С. 697 - 709.e6

Опубликована: Янв. 17, 2024

Diverse animal species exhibit highly stereotyped behavioral actions and locomotor sequences as they explore their natural environments. In many such cases, the neural basis of behavior is well established, where dedicated circuitry contributes to initiation regulation certain response sequences. At microscopic scale, single-celled eukaryotes (protists) also remarkably complex behaviors yet are completely devoid nervous systems. Here, address question how single cells control behavior, we study patterning in exemplary hypotrich ciliate Euplotes, a polarized cell, which actuates large number leg-like appendages called cirri (each bundle ∼25-50 cilia) swim fluids or walk on surfaces. As it navigates its surroundings, walking Euplotes cell routinely observed perform side-stepping reactions, one most sophisticated maneuvers ever organism. These spontaneous reorientation events involving transient fast backward motion followed by turn. Combining high-speed imaging with simultaneous time-resolved electrophysiological recordings, show that this coordinated sequence tightly regulated rapid membrane depolarization events, orchestrate activity different cell. Using machine learning computer vision methods, map detailed measurements dynamics cell's bioelectrical activity, revealing differential front back cirri. We integrate these minimal model understand Euplotes-a unicellular organism-manipulates potential achieve real-time over motor apparatus.

Язык: Английский

Процитировано

8
Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice DOI

Yizhak Sofer,

Noga Zilkha,

Elena Gimpel

и другие.

Nature Neuroscience, Год журнала: 2024, Номер 27(8), С. 1565 - 1573

Опубликована: Июль 5, 2024

Язык: Английский

Процитировано

8
Ecological brain: reframing the study of human behaviour and cognition DOI Creative Commons
Gabriella Vigliocco, Laura Convertino, Sara De Felice

и другие.

Royal Society Open Science, Год журнала: 2024, Номер 11(11)

Опубликована: Ноя. 1, 2024

The last decade has seen substantial advances in the capacity to record behaviour and neural activity humans real-world settings, simulate situations laboratory settings apply sophisticated analyses large-scale data. Along with these developments, a growing number of groups begun advocate for neuroscience cognitive science. Here, we review arguments available methods research outline an overarching framework that embeds key ideas proposed literature integrating them into cyclic process 'bringing lab real world' (recording behavioural settings) lab' (manipulating environments which behaviours occur laboratory) combines exploratory confirmatory is interdisciplinary (including those sciences concerned natural, built or virtual environment). We highlight benefits brought by this emphasizing greater potential novel discovery, theory development human-centred applications environment.

Язык: Английский

Процитировано

8
Molecular circadian rhythms are robust in marine annelids lacking rhythmic behavior DOI Creative Commons
N. Sören Häfker, Laurenz Holcik,

Audrey M. Mat

и другие.

PLoS Biology, Год журнала: 2024, Номер 22(4), С. e3002572 - e3002572

Опубликована: Апрель 11, 2024

The circadian clock controls behavior and metabolism in various organisms. However, the exact timing strength of rhythmic phenotypes can vary significantly between individuals same species. This is highly relevant for rhythmically complex marine environments where organismal diversity likely permits occupation different microenvironments. When investigating locomotor Platynereis dumerilii , a model system molecular chronobiology, we found strain-specific, high variability individual worms. patterns were maintained several weeks. A diel head transcriptome comparison behaviorally versus arrhythmic wild-type worms showed that 24-h cycling core transcripts identical both behavioral phenotypes. While similar total number compared to their counterparts, annotation categories transcripts, however, differed substantially. Consistent with phenotype, exhibit an enrichment related neuronal/behavioral processes. In contrast, increased metabolism- physiology-related transcripts. prominent role neuropeptide pigment-dispersing factor (PDF) Drosophila prompted us test possible functional involvement pdf . Differing from its loss impacts overall activity levels but shows only indirect effects on rhythmicity. Our results show given process rhythmicity others. Across population, exist as continuum, no distinct “boundaries” arrhythmicity. We suggest such rhythm breadth important biodiversity resource enabling species quickly adapt heterogeneous or changing environments. times massive sequencing, our work also emphasizes importance time series tests.

Язык: Английский

Процитировано

7
Centering cognitive neuroscience on task demands and generalization DOI
Matthias Nau, Alexandra C. Schmid, Simon M. Kaplan

и другие.

Nature Neuroscience, Год журнала: 2024, Номер 27(9), С. 1656 - 1667

Опубликована: Июль 29, 2024

Язык: Английский

Процитировано

7
Visuo-frontal interactions during social learning in freely moving macaques DOI Creative Commons
Melissa Franch,

Sudha Yellapantula,

Arun Parajuli

и другие.

Nature, Год журнала: 2024, Номер 627(8002), С. 174 - 181

Опубликована: Фев. 14, 2024

Abstract Social interactions represent a ubiquitous aspect of our everyday life that we acquire by interpreting and responding to visual cues from conspecifics 1 . However, despite the general acceptance this view, how information is used guide decision cooperate unknown. Here, wirelessly recorded spiking activity populations neurons in prefrontal cortex conjunction with wireless recordings oculomotor events while freely moving macaques engaged social cooperation. As animals learned cooperate, executive areas refined representation variables, such as conspecific or reward, distributing socially relevant among each area. Decoding population showed viewing influences cooperate. Learning increased coordinated between cortical neurons, which was associated improved accuracy neural encode These results indicate visual-frontal network prioritizes sensory facilitate learning interact naturalistic environment.

Язык: Английский

Процитировано

6
The neurobiology of vocal communication in marmosets DOI Creative Commons
Dori M. Grijseels,

Brendan Prendergast,

Julia C. Gorman

и другие.

Annals of the New York Academy of Sciences, Год журнала: 2023, Номер 1528(1), С. 13 - 28

Опубликована: Авг. 24, 2023

Abstract An increasingly popular animal model for studying the neural basis of social behavior, cognition, and communication is common marmoset ( Callithrix jacchus ). Interest in this New World primate across neuroscience now being driven by their proclivity prosociality repertoire, high volubility, rapid development, as well amenability to naturalistic testing paradigms freely moving recording imaging technologies. The complement these characteristics set marmosets up be a powerful brain years come. Here, we focus on vocal because it area that has both made most progress illustrates prodigious potential species. We review current state field with various areas networks involved perception production, comparing findings from other animals, including humans.

Язык: Английский

Процитировано

15