What Does the Human Olfactory System Do, and How Does It Do It?
Annual Review of Psychology,
Год журнала:
2023,
Номер
75(1), С. 155 - 181
Опубликована: Окт. 3, 2023
Historically,
the
human
sense
of
smell
has
been
regarded
as
odd
stepchild
senses,
especially
compared
to
sensory
bravado
seeing,
touching,
and
hearing.
The
idea
that
olfaction
little
contribute
our
experience
world
is
commonplace,
though
with
emergence
COVID-19
there
rather
a
sea
change
in
this
understanding.
An
ever
increasing
body
work
convincingly
highlighted
keen
capabilities
nose
sophistication
olfactory
system.
Here,
we
provide
concise
overview
neuroscience
spanning
last
10–15
years,
focus
on
peripheral
central
mechanisms
underlie
how
odor
information
processed,
packaged,
parceled,
predicted,
perturbed
serve
odor-guided
behaviors.
We
conclude
by
offering
some
guideposts
for
harnessing
next
decade
research
all
its
shapes
forms.
Язык: Английский
Predictive coding in the human olfactory system
Trends in Cognitive Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Язык: Английский
Grid codes underlie multiple cognitive maps in the human brain
Progress in Neurobiology,
Год журнала:
2024,
Номер
233, С. 102569 - 102569
Опубликована: Янв. 15, 2024
Язык: Английский
Leveraging Multi-echo EPI to Enhance BOLD Sensitivity in Task-based Olfactory fMRI
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 16, 2024
Abstract
Functional
magnetic
resonance
imaging
(fMRI)
using
blood-oxygenation-level-dependent
(BOLD)
contrast
relies
on
gradient
echo
echo-planar
(GE-EPI)
to
quantify
dynamic
susceptibility
changes
associated
with
the
hemodynamic
response
neural
activity.
However,
acquiring
BOLD
fMRI
in
human
olfactory
regions
is
particularly
challenging
due
their
proximity
sinuses
where
large
gradients
induce
field
distortions.
of
system
further
complicated
by
respiratory
artifacts
that
are
highly
correlated
event
onsets
tasks.
Multi-echo
EPI
(ME-EPI)
acquires
data
at
multiple
times
(TEs)
during
a
single
acquisition
and
can
leverage
signal
evolution
over
enhance
sensitivity
reduce
artifactual
contributions.
In
current
study,
we
developed
ME-EPI
protocol
for
task-based
demonstrated
significant
improvement
conventional
single-echo
(1E-EPI).
The
observed
arose
from
both
an
increase
through
T
2
*
-weighted
combination
reduction
non-BOLD
application
Multi-Echo
Independent
Components
Analysis
(ME-ICA)
denoising
method.
This
study
represents
one
first
direct
comparisons
between
1E-EPI
high-susceptibility
provides
compelling
evidence
favor
future
studies.
Язык: Английский
How do mammals convert dynamic odor information into neural maps for landscape navigation?
PLoS Biology,
Год журнала:
2024,
Номер
22(11), С. e3002908 - e3002908
Опубликована: Ноя. 21, 2024
Odors
are
transported
by
seemingly
chaotic
plumes,
whose
spatiotemporal
structure
contains
rich
information
about
space,
with
olfaction
serving
as
a
gateway
for
obtaining
and
processing
this
spatial
information.
Beyond
tracking
odors,
provides
localization
chemical
communication
cues
detecting
conspecifics
predators,
linking
external
environments
to
internal
cognitive
maps.
In
Essay,
we
discuss
recent
physiological,
behavioral,
methodological
advancements
in
mammalian
olfactory
research
present
our
current
understanding
of
how
can
be
used
navigate
the
environment.
We
also
examine
potential
neural
mechanisms
that
might
convert
dynamic
inputs
into
environmental
maps
along
axis.
Finally,
consider
technological
applications
odor
dynamics
developing
bio-inspired
sensor
technologies,
robotics,
computational
models.
By
shedding
light
on
principles
underlying
dynamics,
will
pave
way
innovative
solutions
bridge
gap
between
biology
technology,
enriching
natural
world.
Язык: Английский
SMELLS IN LANDSCAPE ARCHITECTURE AND URBAN SPACES
Опубликована: Ноя. 14, 2024
This
article
discusses
the
significance
of
odors
in
landscape
architecture
and
urban
spaces,
their
influence
on
emotional
physiological
state
people,
as
well
methods
using
scents
to
create
unique
ecological
architectural
solutions.
The
study
includes
analysis
various
aspects
such
psychological
features
odor
perception,
technologies
techniques
introducing
aromatic
elements
into
environments,
recommendations
for
use
planning
design
spaces.
Язык: Английский
An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease
Journal of Alzheimer s Disease Reports,
Год журнала:
2024,
Номер
8(1), С. 1722 - 1744
Опубликована: Июль 1, 2024
Elucidating
Alzheimer's
disease
(AD)
prodromal
symptoms
can
resolve
the
outstanding
challenge
of
early
diagnosis.
Based
on
intrinsically
related
substrates
olfaction
and
spatial
navigation,
we
propose
a
novel
experimental
framework
for
their
conjoint
study.
Artificial
intelligence-driven
multimodal
study
combining
self-collected
olfactory
motion
data
with
available
big
clinical
datasets
potentially
promote
high-precision
screenings
to
facilitate
timely
interventions
targeting
neurodegenerative
progression.
Язык: Английский
Cognitive maps: Constructing a route with your snout
Current Biology,
Год журнала:
2023,
Номер
33(18), С. R963 - R965
Опубликована: Сен. 1, 2023
Язык: Английский
The spatial periodic computation of hippocampus-entorhinal circuit in navigation
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Янв. 31, 2022
To
achieve
the
computational
goal
of
navigating
in
both
physical
and
mental
spaces,
human
brain
employs
a
cognitive
map
constructed
by
global
metrics
entorhinal
cortex
local
locations
hippocampus.
However,
mechanism
which
these
two
areas
interact
to
support
navigation
remains
unclear.
Here,
we
designed
an
object-matching
task
where
participants
unknowingly
manipulated
object
variants
arranged
ring-like
structure
around
central
prototype.
Functional
MRI
revealed
3-fold
spatial
periodicity
hippocampal
activity,
tracked
trajectories
from
original
prototype
space.
Importantly,
this
hippocampus
was
phase-locked
with
well-documented
6-fold
cortex,
suggesting
periodic
connecting
areas.
In
addition,
replicated
behavior,
varied
function
directions
activity.
Finally,
proposed
EC-HPC
PhaseSync
model,
illustrating
framework
hippocampal-entorhinal
network,
grid
cell
populations
embeds
vector
fields
that
are
represented
for
conceptual
navigation.
Язык: Английский