The spatial periodic computation of hippocampus-entorhinal circuit in navigation DOI Creative Commons
Bo Zhang, Xin Guan, Dean Mobbs

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 31, 2022

To achieve the computational goal of navigating in both physical and mental spaces, human brain employs a cognitive map constructed by global metrics entorhinal cortex local locations hippocampus. However, mechanism which these two areas interact to support navigation remains unclear. Here, we designed an object-matching task where participants unknowingly manipulated object variants arranged ring-like structure around central prototype. Functional MRI revealed 3-fold spatial periodicity hippocampal activity, tracked trajectories from original prototype space. Importantly, this hippocampus was phase-locked with well-documented 6-fold cortex, suggesting periodic connecting areas. In addition, replicated behavior, varied function directions activity. Finally, proposed EC-HPC PhaseSync model, illustrating framework hippocampal-entorhinal network, grid cell populations embeds vector fields that are represented for conceptual navigation.

Language: Английский

What Does the Human Olfactory System Do, and How Does It Do It? DOI Creative Commons
Gülce Nazlı Dikeçligil, Jay A. Gottfried

Annual Review of Psychology, Journal Year: 2023, Volume and Issue: 75(1), P. 155 - 181

Published: Oct. 3, 2023

Historically, the human sense of smell has been regarded as odd stepchild senses, especially compared to sensory bravado seeing, touching, and hearing. The idea that olfaction little contribute our experience world is commonplace, though with emergence COVID-19 there rather a sea change in this understanding. An ever increasing body work convincingly highlighted keen capabilities nose sophistication olfactory system. Here, we provide concise overview neuroscience spanning last 10–15 years, focus on peripheral central mechanisms underlie how odor information processed, packaged, parceled, predicted, perturbed serve odor-guided behaviors. We conclude by offering some guideposts for harnessing next decade research all its shapes forms.

Language: Английский

Citations

10
Predictive coding in the human olfactory system DOI

Sam Lyons,

Jay A. Gottfried

Trends in Cognitive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Grid codes underlie multiple cognitive maps in the human brain DOI
Dong Chen, Nikolai Axmacher, Liang Wang

et al.

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 233, P. 102569 - 102569

Published: Jan. 15, 2024

Language: Английский

Citations

1
Leveraging Multi-echo EPI to Enhance BOLD Sensitivity in Task-based Olfactory fMRI DOI Open Access
Ludwig Sichen Zhao, Clara U. Raithel, M. Dylan Tisdall

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 16, 2024

Abstract Functional magnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (BOLD) contrast relies on gradient echo echo-planar (GE-EPI) to quantify dynamic susceptibility changes associated with the hemodynamic response neural activity. However, acquiring BOLD fMRI in human olfactory regions is particularly challenging due their proximity sinuses where large gradients induce field distortions. of system further complicated by respiratory artifacts that are highly correlated event onsets tasks. Multi-echo EPI (ME-EPI) acquires data at multiple times (TEs) during a single acquisition and can leverage signal evolution over enhance sensitivity reduce artifactual contributions. In current study, we developed ME-EPI protocol for task-based demonstrated significant improvement conventional single-echo (1E-EPI). The observed arose from both an increase through T 2 * -weighted combination reduction non-BOLD application Multi-Echo Independent Components Analysis (ME-ICA) denoising method. This study represents one first direct comparisons between 1E-EPI high-susceptibility provides compelling evidence favor future studies.

Language: Английский

Citations

1
How do mammals convert dynamic odor information into neural maps for landscape navigation? DOI Creative Commons

Anantu Sunil,

Olivia Pedroncini, Andreas T. Schaefer

et al.

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(11), P. e3002908 - e3002908

Published: Nov. 21, 2024

Odors are transported by seemingly chaotic plumes, whose spatiotemporal structure contains rich information about space, with olfaction serving as a gateway for obtaining and processing this spatial information. Beyond tracking odors, provides localization chemical communication cues detecting conspecifics predators, linking external environments to internal cognitive maps. In Essay, we discuss recent physiological, behavioral, methodological advancements in mammalian olfactory research present our current understanding of how can be used navigate the environment. We also examine potential neural mechanisms that might convert dynamic inputs into environmental maps along axis. Finally, consider technological applications odor dynamics developing bio-inspired sensor technologies, robotics, computational models. By shedding light on principles underlying dynamics, will pave way innovative solutions bridge gap between biology technology, enriching natural world.

Language: Английский

Citations

1
SMELLS IN LANDSCAPE ARCHITECTURE AND URBAN SPACES DOI

E. Anoshko,

Tat'yana Malinina

Published: Nov. 14, 2024

This article discusses the significance of odors in landscape architecture and urban spaces, their influence on emotional physiological state people, as well methods using scents to create unique ecological architectural solutions. The study includes analysis various aspects such psychological features odor perception, technologies techniques introducing aromatic elements into environments, recommendations for use planning design spaces.

Language: Английский

Citations

0
An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease DOI Creative Commons
Katarina Biljman, Illana Gozes, Jacqueline C. K. Lam

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2024, Volume and Issue: 8(1), P. 1722 - 1744

Published: July 1, 2024

Elucidating Alzheimer's disease (AD) prodromal symptoms can resolve the outstanding challenge of early diagnosis. Based on intrinsically related substrates olfaction and spatial navigation, we propose a novel experimental framework for their conjoint study. Artificial intelligence-driven multimodal study combining self-collected olfactory motion data with available big clinical datasets potentially promote high-precision screenings to facilitate timely interventions targeting neurodegenerative progression.

Language: Английский

Citations

0
Cognitive maps: Constructing a route with your snout DOI Creative Commons
Mark A. Orloff, Erie D. Boorman

Current Biology, Journal Year: 2023, Volume and Issue: 33(18), P. R963 - R965

Published: Sept. 1, 2023

Language: Английский

Citations

0
The spatial periodic computation of hippocampus-entorhinal circuit in navigation DOI Creative Commons
Bo Zhang, Xin Guan, Dean Mobbs

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 31, 2022

To achieve the computational goal of navigating in both physical and mental spaces, human brain employs a cognitive map constructed by global metrics entorhinal cortex local locations hippocampus. However, mechanism which these two areas interact to support navigation remains unclear. Here, we designed an object-matching task where participants unknowingly manipulated object variants arranged ring-like structure around central prototype. Functional MRI revealed 3-fold spatial periodicity hippocampal activity, tracked trajectories from original prototype space. Importantly, this hippocampus was phase-locked with well-documented 6-fold cortex, suggesting periodic connecting areas. In addition, replicated behavior, varied function directions activity. Finally, proposed EC-HPC PhaseSync model, illustrating framework hippocampal-entorhinal network, grid cell populations embeds vector fields that are represented for conceptual navigation.

Language: Английский

Citations

0