Olfactory testing in infants with perinatal asphyxia: enhancing encephalopathy risk stratification for future health outcomes

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106029 - 106029

Опубликована: Янв. 1, 2025

Язык: Английский

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A nasal chemosensation–dependent critical window for somatosensory development

Science, Год журнала: 2024, Номер 384(6696), С. 652 - 660

Опубликована: Май 9, 2024

Nasal chemosensation is considered the evolutionarily oldest mammalian sense and, together with somatosensation, crucial for neonatal well-being before auditory and visual pathways start engaging brain. Using anatomical functional approaches in mice, we reveal that odor-driven activity propagates to a large part of cortex during first postnatal week enhances whisker-evoked activation primary whisker somatosensory (wS1). This effect disappears adult animals, line loss excitatory connectivity from olfactory wS1. By performing odor deprivation, followed by electrophysiological behavioral work identify key transient regulation nasal chemosensory information necessary development wS1 sensory-driven dynamics somatosensation. Our uncovers cross-modal critical window chemosensation-dependent maturation.

Язык: Английский

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Differences in Cajal-Retzius cell density and postnatal persistence across cortical areas revealed by a novel intersectional genetic labeling approach

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

ABSTRACT Cajal-Retzius (CR) cells are glutamatergic neurons that transiently populate the most superficial layer of isocortex and allocortex during development, serving an essential role both prenatal early postnatal brain development. Notably, these disappear from cortical areas by day 14, but persist for much longer in hippocampus. We developed a novel intersectional genetic labeling approach CR captures almost all TRP73-positive throughout allocortex. This strategy offers several advantages over previous methods commonly used cell targeting. Here, we applied this new to investigate distribution persistence whole mouse brain, at four different ages. observed initial density rate their disappearance varies substantially across Strikingly, variation death even between adjacent subregions: comparing medial lateral entorhinal cortex, former retains high months contrast latter. Our results present necessary revision phenomenon persistence, showing that, addition hippocampus, other maintain beyond first two weeks.

Язык: Английский

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A long-term mixed eosinophilic and neutrophilic chronic rhinosinusitis C57BL/6 mouse model with neuroinflammation, olfactory dysfunction and anxiety-like behaviors

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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D2 receptor activation modulates NMDA receptor antagonist-enhanced high-frequency oscillations in the olfactory bulb of freely moving rats

Psychopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Язык: Английский

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Protosequences in human cortical organoids model intrinsic states in the developing cortex

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 30, 2023

Neuronal firing sequences are thought to be the basic building blocks of neural coding and information broadcasting within brain. However, when emerge during neurodevelopment remains unknown. We demonstrate that structured present in spontaneous activity human murine brain organoids ex vivo neonatal slices from somatosensory cortex. observed a balance between temporally rigid flexible patterns emergent phenomena early postnatal cortex, but not primary dissociated cortical cultures. Our findings suggest temporal do arise an experience-dependent manner, rather constrained by innate preconfigured architecture established neurogenesis. These highlight potential for further explore how exogenous inputs can used refine neuronal circuits enable new studies into genetic mechanisms govern assembly functional circuitry development.

Язык: Английский

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Olfactory bulb-medial prefrontal cortex theta synchronization is associated with anxiety

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 27, 2024

Abstract Anxiety is among the most fundamental mammalian behaviors. Despite physiological and pathological importance, its underlying neural mechanisms remain poorly understood. Here, we recorded activity of olfactory bulb (OB) medial prefrontal cortex (mPFC) rats, which are critical structures to brain’s emotional processing network, while exploring different anxiogenic environments. Our results show that presence in contexts increases OB mPFC regional theta activities. Also, these local changes associated with enhanced OB-mPFC power- phase-based functional connectivity as well OB-to-mPFC information transfer. Interestingly, effects more prominent unsafe zones environments, compared safer zones. This consistent trend diverse behavioral environments long-range features suggest dynamics circuit oscillations might underlie types anxiety behaviors, possible implications for disorders.

Язык: Английский

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Modifying Alzheimer’s disease pathophysiology with photobiomodulation: model, evidence, and future with EEG-guided intervention

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Авг. 23, 2024

This manuscript outlines a model of Alzheimer’s Disease (AD) pathophysiology in progressive layers, from its genesis to the development biomarkers and then symptom expression. Genetic predispositions are major factor that leads mitochondrial dysfunction subsequent amyloid tau protein accumulation, which have been identified as hallmarks AD. Extending beyond these accumulations, we explore broader spectrum pathophysiological aspects, including blood–brain barrier, blood flow, vascular health, gut-brain microbiodata, glymphatic metabolic syndrome, energy deficit, oxidative stress, calcium overload, inflammation, neuronal synaptic loss, brain matter atrophy, reduced growth factors. Photobiomodulation (PBM), delivers near-infrared light selected regions using portable devices, is introduced therapeutic approach. PBM has potential address each with data provided by various studies. They provide mechanistic support for largely small published clinical studies demonstrate improvements memory cognition. inform PBM’s treat AD pending validation large randomized controlled The presentation network waveform changes on electroencephalography (EEG) opportunity use guide application parameters improve outcomes. These include wavelength, power density, treatment duration, LED positioning, pulse frequency. Pulsing at specific frequencies found influence expression waveforms modifications networks. stems modulation cellular structures revealed recent findings an EEG-based artificial intelligence personalize through EEG feedback.

Язык: Английский

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Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 30, 2024

Olfactory dysfunction has emerged as a hallmark feature shared among several neurological conditions, including both neurodevelopmental and neurodegenerative disorders. While diseases of categories have been extensively studied for decades, their association with olfaction only recently gained attention. deficits often manifest already during prodromal stages these diseases, yet it remains unclear whether common pathophysiological changes along olfactory pathways cause such impairments. Here we probe into the intricate relationship between disorders, shedding light on commonalities underlying mechanisms. We begin by providing brief overview circuit its connections to higher-associated brain areas. Additionally, discuss in focusing potential mechanisms that may contribute across types further debate disease propagation or are simply an epiphenomenon. conclude emphasizing significance function pre-clinical diagnostic tool identify individuals disorders offers opportunity preventive intervention before other symptoms manifest.

Язык: Английский

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Developmental olfactory dysfunction and abnormal odor memory in immune-challenged Disc1+/- mice

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 17, 2024

Abstract Neuronal activity in the olfactory bulb (OB) drives coordinated hippocampal-prefrontal network during early development. Inhibiting OB output neonatal mice disrupts functional development of hippocampal formation as well cognitive abilities. These impairments manifest life and resemble dysfunctions hippocampus prefrontal cortex that have been linked to neuropsychiatric disorders. Thus, we investigated a disease mouse model asked whether might be altered, thereby contributing dysfunctional network. We addressed this question by combining vivo electrophysiology with behavioral assessment immune-challenged Disc1 +/- mimic dual genetic-environmental etiology In wildtype mice, found high DISC1 expression levels projection neurons Furthermore, neuronal OB, drive from were reduced This deficit did not affect odor-evoked odor perception but resulted impaired long-term memory. propose endogenous developing contributes altered maturation network, leading memory impairment mice.

Язык: Английский

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