Impact of Physical Activity, Sedentary Behavior, and Basal Metabolic Rate on PTSD, Depression, and Emotional Instability DOI Creative Commons

Tianyi Lyu,

Haonan Qian,

Sung-Pil Chung

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1071 - 1071

Опубликована: Окт. 27, 2024

Objective: This study aimed to investigate the potential associations between physical activity, sedentary behavior, and basal metabolic rate (BMR) with post-traumatic stress disorder (PTSD), major depressive (MDD), emotional instability (EI) using bidirectional Mendelian randomization (MR). Additionally, it sought identify key molecular mechanisms underlying through a comprehensive bioinformatic analysis. Methods: MR analyses utilizing genome-wide association (GWAS) data were conducted estimate effects of BMR on PTSD, MDD, EI. Sensitivity performed assess robustness findings. Concurrently, analysis was executed gene expression datasets (GSE53987 GSE21138) derived from emotionally unstable patients. encompassed differential differentially expressed genes (DEGs), followed by an functional enrichment uncover pathways associated Results: The revealed that increased activity may have protective effect against albeit inconsistent MDD Sedentary behavior demonstrated minimal or identified 114 DEGs EI, YWHAB, SRRM2, MST1, HDAC10, HSPA1A highlighted as significant genes. these unveiled potentially involved in pathology instability. Conclusions: Physical appears protect whereas its EI are less definitive. findings offer deeper understanding pinpointing specific serve therapeutic targets. Further research is warranted elucidate intricate interactions mechanisms.

Язык: Английский

A potentiation of REM sleep-active neurons in the lateral habenula may be responsible for the sleep disturbance in depression DOI

Zehui Zhang,

Wei Zhang,

Yuanyuan Fang

и другие.

Current Biology, Год журнала: 2024, Номер 34(15), С. 3287 - 3300.e6

Опубликована: Июнь 28, 2024

Язык: Английский

Процитировано

5
Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved DOI Creative Commons
Rui Fan, Yingmin Jia, Zhou Chen

и другие.

Foods, Год журнала: 2025, Номер 14(7), С. 1080 - 1080

Опубликована: Март 21, 2025

Insomnia affects one-third of the world’s population; negative effects insomnia are significant, and traditional medications have numerous side cause considerable suffering. This has aroused interest in obtaining sleep-improving substances from foods. study conducted a comprehensive literature review using Web Science PubMed with keywords like “sleep”, “insomnia”, “food”. A subsequent summary revealed that certain foods, including milk, Ziziphus jujuba, Lactuca sativa, ginseng, Schisandra chinensis, Juglans regia, etc., purported to enhance sleep quality by prolonging duration, reducing latency, alleviating anxiety. The mechanisms these foods’ mainly occur via central nervous system, particularly gamma-aminobutyric acid (GABA)ergic 5-hydroxytryptamine (5-HT)ergic systems. Although this supports fact they potential, further research is needed. There also issues such as more limited fewer mechanisms, pharmacokinetic studies, models being involved. These need be addressed future adequately address problem insomnia. It hoped will contribute into foods properties and, future, provide an effective natural alternative for those seeking medication.

Язык: Английский

Процитировано

0
Slumber under pressure: REM sleep and stress response DOI
Bernhard Schaefke,

Jingfei Li,

Binghao Zhao

и другие.

Progress in Neurobiology, Год журнала: 2025, Номер unknown, С. 102771 - 102771

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Mental health: The REM sleep paradox in depression DOI
Emi Hasegawa, Michael Lazarus

Current Biology, Год журнала: 2024, Номер 34(15), С. R739 - R741

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

0
Impact of Physical Activity, Sedentary Behavior, and Basal Metabolic Rate on PTSD, Depression, and Emotional Instability DOI Creative Commons

Tianyi Lyu,

Haonan Qian,

Sung-Pil Chung

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1071 - 1071

Опубликована: Окт. 27, 2024

Objective: This study aimed to investigate the potential associations between physical activity, sedentary behavior, and basal metabolic rate (BMR) with post-traumatic stress disorder (PTSD), major depressive (MDD), emotional instability (EI) using bidirectional Mendelian randomization (MR). Additionally, it sought identify key molecular mechanisms underlying through a comprehensive bioinformatic analysis. Methods: MR analyses utilizing genome-wide association (GWAS) data were conducted estimate effects of BMR on PTSD, MDD, EI. Sensitivity performed assess robustness findings. Concurrently, analysis was executed gene expression datasets (GSE53987 GSE21138) derived from emotionally unstable patients. encompassed differential differentially expressed genes (DEGs), followed by an functional enrichment uncover pathways associated Results: The revealed that increased activity may have protective effect against albeit inconsistent MDD Sedentary behavior demonstrated minimal or identified 114 DEGs EI, YWHAB, SRRM2, MST1, HDAC10, HSPA1A highlighted as significant genes. these unveiled potentially involved in pathology instability. Conclusions: Physical appears protect whereas its EI are less definitive. findings offer deeper understanding pinpointing specific serve therapeutic targets. Further research is warranted elucidate intricate interactions mechanisms.

Язык: Английский

Процитировано

0