Presynaptic inhibition selectively suppresses leg proprioception in behavingDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 23, 2023

Controlling arms and legs requires feedback from proprioceptive sensory neurons that detect joint position movement. Proprioceptive must be tuned for different behavioral contexts, but the underlying circuit mechanisms remain poorly understood. Using calcium imaging in behaving

Язык: Английский

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Divergent neural circuits for proprioceptive and exteroceptive sensing of theDrosophilaleg

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 28, 2024

Abstract Somatosensory neurons provide the nervous system with information about mechanical forces originating inside and outside body. Here, we use connectomics from electron microscopy to reconstruct analyze neural circuits downstream of largest somatosensory organ in Drosophila leg, femoral chordotonal (FeCO). The FeCO has been proposed support both proprioceptive sensing fly’s femur-tibia joint exteroceptive substrate vibrations, but it was unknown which sensory central contribute each these functions. We found that different subtypes feed into distinct pathways. Position- movement-encoding connect local leg motor control ventral nerve cord (VNC), indicating a function. In contrast, signals vibration-encoding are integrated across legs transmitted mechanosensory regions brain, an Overall, our analyses reveal structure specialized for processing fly leg. These findings consistent growing body work invertebrate vertebrate species demonstrating existence limb pathways external vibrations.

Язык: Английский

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Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

Опубликована: Март 20, 2025

Walking animals must maintain stability in the presence of external perturbations, despite significant temporal delays neural signaling and muscle actuation. Here, we develop a 3D kinematic model with layered control architecture to investigate how sensorimotor constrain robustness walking behavior fruit fly, Drosophila. Motivated by anatomical insect locomotor circuits, our consists three component layers: network that generates realistic joint kinematics for each leg, an optimal controller executes while accounting delays, inter-leg coordinator. The simulated resembles real fly sustains even when subjected unexpected generalizing beyond its training data. However, found model’s perturbations deteriorates delay parameters exceed physiological range. These results suggest circuits operate close limit at which they can detect respond perturbations. More broadly, show modular, be used constraints on animal behavior.

Язык: Английский

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Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 22, 2024

Abstract Walking animals must maintain stability in the presence of external perturbations, despite significant temporal delays neural signaling and muscle actuation. Here, we develop a 3D kinematic model with layered control architecture to investigate how sensorimotor constrain robustness walking behavior fruit fly, Drosophila. Motivated by anatomical insect locomotor circuits, our consists three component layers: network that generates realistic joint kinematics for each leg, an optimal controller executes while accounting delays, inter-leg coordinator. The simulated resembles real fly sustains even when subjected unexpected generalizing beyond its training data. However, found model’s perturbations deteriorates delay parameters exceed physiological range. These results suggest circuits operate close limit at which they can detect respond perturbations. More broadly, show modular, be used constraints on animal behavior.

Язык: Английский

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The Fly Disco: Hardware and software for optogenetics and fine-grained fly behavior analysis

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract In the fruit fly, Drosophila melanogaster , connectome data and genetic tools provide a unique opportunity to study complex behaviors including navigation, mating, aggression, grooming in an organism with tractable nervous system of 140,000 neurons. Here we present Fly Disco, flexible for high quality video collection, optogenetic manipulation, fine-grained behavioral analysis freely walking socializing fly groups. The collection hardware software automates videos synced programmable stimuli. Key pipeline features include based on trajectories 21 keypoints optogenetic-specific summary statistics visualization. We created multifly dataset pose estimation that includes 9701 examples enriched behaviors. All designs, software, are available.

Язык: Английский

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Alkoholtest für Würmer

Nachrichten aus der Chemie, Год журнала: 2024, Номер 72(12), С. 98 - 98

Опубликована: Дек. 1, 2024

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