Food & Function, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Hypobaric hypoxia causes oxidative stress and inflammatory responses disrupts the gut microbiome metabolome. In this study, we developed a synbiotic fermented whey beverage, combining kefir
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1174 - 1174
Опубликована: Янв. 29, 2025
Exploring how early-life nutritional interventions may impact future generations, this study examines the inter- and transgenerational effects of in ovo injection bioactive compounds on gene expression cecal tonsils mucosa using a chicken model. Synbiotic PoultryStar® (Biomin) choline were injected 12th day egg incubation. Three experimental groups established generation F1: (1) control group (C) receiving 0.9% physiological saline (NaCl), (2) synbiotic (SYN) 2 mg/embryo, (3) combined (SYNCH) mg 0.25 per embryo. For generations F2 F3, SYN SYNCH each divided into two subgroups: (A) those solely F1 (SYNs SYNCHs) (B) (SYNr SYNCHr). At 21 weeks posthatching, tonsil samples collected from F1, F2, F3 birds for transcriptomic analysis. Gene profiling revealed distinct intergenerational patterns both tissues. In tonsils, significant was noted following drop F2. contrast, showed more changes indicating effects. While some carried they less pronounced, except SYNs group, which experienced an increase compared to The highlights that epigenetic modifications are dynamic unpredictable, with potentially re-emerging later under certain conditions or fading intensifying over time. This provides valuable insights stimulation during embryonic development regulate processes across multiple generations. Our findings provide evidence supporting phenomenon dynamics
Язык: Английский
Процитировано
1
Metabolites, Год журнала: 2025, Номер 15(2), С. 127 - 127
Опубликована: Фев. 13, 2025
Numerous recent studies have suggested that the composition of intestinal microbiota can trigger metabolic disorders, such as diabetes, prediabetes, obesity, syndrome, sarcopenia, dyslipidemia, hyperhomocysteinemia, and non-alcoholic fatty liver disease. Since then, considerable effort has been made to understand link between well role probiotics in modulation microbiota. The aim this review was summarize reviews individual articles on state art regarding ideal therapy with prebiotics order obtain reversion dysbiosis (alteration microbiota) eubiosis during diseases, diseases. This includes 245 eligible studies. In conclusion, a condition dysbiosis, or general, alteration microbiota, could be implicated development disorders through different mechanisms, mainly linked release pro-inflammatory factors. Several already demonstrated potential using treatment condition, detecting significant improvements specific symptoms These findings reinforce hypothesis lead generalized inflammatory picture negative consequences organs systems. Moreover, confirms beneficial effects diseases are promising, but more research is needed determine optimal probiotic strains, doses, administration forms for conditions.
Язык: Английский
Процитировано
1
World Journal of Microbiology and Biotechnology, Год журнала: 2024, Номер 40(9)
Опубликована: Июль 27, 2024
Язык: Английский
Процитировано
5
Food & Function, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Hypobaric hypoxia causes oxidative stress and inflammatory responses disrupts the gut microbiome metabolome. In this study, we developed a synbiotic fermented whey beverage, combining kefir
Язык: Английский
Процитировано
0