Neonatal febrile seizures: Dimethyl itaconate’s role in behavioral recovery and glutathione enzyme modulation in adult rats
PLoS ONE,
Год журнала:
2025,
Номер
20(3), С. e0318430 - e0318430
Опубликована: Март 25, 2025
Febrile
seizures
are
common
in
children
and
can
lead
to
neurological
deficits
like
motor
impairments,
memory
problems,
cognitive
decline.
Research
on
dimethyl
itaconate
aims
mitigate
these
effects
improve
the
quality
of
life
for
affected
people.
By
exploring
its
potential
as
a
protective
agent
against
oxidative
stress
during
seizures,
this
study
adult
male
rats
measures
activity
key
enzymes
related
behavioral
performance.
Pregnant
were
divided
into
control,
sham,
DMI,
febrile
seizure,
DMI
+
seizure
groups.
Seizure
severity
was
evaluated
through
threshold
frequency
measurements,
while
memory,
function,
balance
assessed
using
shuttle
box,
rotarod,
open
field,
wire
hanging
tests.
After
that,
hippocampus
tissue
removed
from
brain
levels
MDA,
SOD,
GSH,
TAC,
GR,
GPx,
catalase
measured
biochemical
methods.
Results
show
that
raised
reduced
tonic-clonic
seizures.
The
group
also
showed
improved
movement,
compared
(p
<
0.05
all
cases).
Overall,
decreased
outcomes
fever-affected
rats.
Язык: Английский
Post-cerebral ischemia energy crisis: the role of glucose metabolism in the energetic crisis
Brain Injury,
Год журнала:
2025,
Номер
unknown, С. 1 - 11
Опубликована: Апрель 16, 2025
Cells
universally
employ
an
efficiency-driven
metabolic
switch
mechanism
during
nutritional
changes,
growth,
and
differentiation,
transitioning
from
oxidative
phosphorylation
(OXPHOS)
to
glycolysis
ensure
survival
under
hypoxic
conditions
or
high
energy
demands.
In
cerebral
ischemia,
inadequate
blood
supply
causes
oxygen
deprivation,
prompting
brain
cells
initiate
glycolytic
reprogramming
meet
urgent
needs.
While
this
adaptation
is
a
temporary
solution,
it
may
lead
lactic
acidosis,
aggravated
inflammation,
increased
free
radical
production.
Prolonged
reperfusion
with
sustained
can
exacerbate
cell
damage,
potentially
causing
irreversible
harm.
This
review
systematically
examines
the
dynamic
changes
in
glucose
transport
mechanisms
roles
of
immediate,
early,
intermediate,
late
responder
cells,
along
their
regulatory
factors,
reprogramming.
Using
temporal
analysis
framework
based
on
body's
natural
response
sequence
pathological
events,
we
elucidate
how
at
different
stages
collaborate
address
metabolism
conditions.
Reversing
inhibiting
improve
processes
ischemic
stroke,
offering
potential
therapeutic
benefits.
Язык: Английский