Neonatal febrile seizures: Dimethyl itaconate’s role in behavioral recovery and glutathione enzyme modulation in adult rats

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0318430 - e0318430

Published: March 25, 2025

Febrile seizures are common in children and can lead to neurological deficits like motor impairments, memory problems, cognitive decline. Research on dimethyl itaconate aims mitigate these effects improve the quality of life for affected people. By exploring its potential as a protective agent against oxidative stress during seizures, this study adult male rats measures activity key enzymes related behavioral performance. Pregnant were divided into control, sham, DMI, febrile seizure, DMI + seizure groups. Seizure severity was evaluated through threshold frequency measurements, while memory, function, balance assessed using shuttle box, rotarod, open field, wire hanging tests. After that, hippocampus tissue removed from brain levels MDA, SOD, GSH, TAC, GR, GPx, catalase measured biochemical methods. Results show that raised reduced tonic-clonic seizures. The group also showed improved movement, compared (p < 0.05 all cases). Overall, decreased outcomes fever-affected rats.

Language: Английский

Post-cerebral ischemia energy crisis: the role of glucose metabolism in the energetic crisis

Brain Injury, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 16, 2025

Cells universally employ an efficiency-driven metabolic switch mechanism during nutritional changes, growth, and differentiation, transitioning from oxidative phosphorylation (OXPHOS) to glycolysis ensure survival under hypoxic conditions or high energy demands. In cerebral ischemia, inadequate blood supply causes oxygen deprivation, prompting brain cells initiate glycolytic reprogramming meet urgent needs. While this adaptation is a temporary solution, it may lead lactic acidosis, aggravated inflammation, increased free radical production. Prolonged reperfusion with sustained can exacerbate cell damage, potentially causing irreversible harm. This review systematically examines the dynamic changes in glucose transport mechanisms roles of immediate, early, intermediate, late responder cells, along their regulatory factors, reprogramming. Using temporal analysis framework based on body's natural response sequence pathological events, we elucidate how at different stages collaborate address metabolism conditions. Reversing inhibiting improve processes ischemic stroke, offering potential therapeutic benefits.

Language: Английский