Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease

The Lancet Diabetes & Endocrinology, Год журнала: 2023, Номер 11(12), С. 926 - 941

Опубликована: Окт. 18, 2023

Язык: Английский

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Puberty differentially predicts brain maturation in male and female youth: A longitudinal ABCD Study

Developmental Cognitive Neuroscience, Год журнала: 2023, Номер 61, С. 101261 - 101261

Опубликована: Июнь 1, 2023

Research has demonstrated associations between pubertal development and brain maturation. However, existing studies have been limited by small samples, cross-sectional designs, inconclusive findings regarding directionality of effects sex differences. We examined the longitudinal temporal coupling puberty status assessed using Pubertal Development Scale (PDS) magnetic resonance imaging (MRI)-based grey white matter structure. Our sample consisted 8896 children adolescents at baseline (mean age = 9.9) 6099 follow-up 11.9) from Adolescent Brain Cognitive (ABCD) Study cohort. Applying multigroup Bivariate Latent Change Score (BLCS) models, we found that PDS predicted rate change in cortical thickness among females surface area for both males females. also a correlation co-occurring changes over time males. Diffusion tensor (DTI) analyses revealed correlated fractional anisotropy (FA) females, but no significant mean diffusivity (MD). results suggest predicts maturation, strength differ sex. Further research spanning entire duration is needed to understand extent contribution on youth brain.

Язык: Английский

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The role of pubertal development in the association between trauma and internalising symptoms in female youth

Journal of Child Psychology and Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Background Exposure to trauma in childhood is associated with an increased risk for internalising symptoms. Alterations pubertal development has been proposed as a potential mechanism underpinning this association. However, longitudinal studies, which are needed examine over time, scarce. The goal of pre‐registered study was how exposure shapes the timing and tempo development, turn contributes symptoms female youth. Methods Using largest sample date, we characterised profiles across four time points youth from Adolescent Brain Cognitive Development (ABCD) Study ( N = 4,225, age range 9–14 years) using latent profile analysis. Pubertal assessed Scale (at points). Trauma quantified post‐traumatic stress disorder subscale parent‐report Kiddie Schedule Affective Disorders Schizophrenia DSM‐5 baseline), were self‐report Brief Problem Monitor 3‐year follow‐up). Results could be grouped into three classes: early starters (9% sample), typical developers (76%) slow (15%). demonstrated higher levels compared developers, while showed least trauma. Youth greater at ages 12–14 years, association mediated by status 9–10 but not faster tempo. Conclusions Accelerated earlier onset transition late adolescence, may through increases

Язык: Английский

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Children’s early signs and developmental trajectories of psychotic-like experiences

Brain Research, Год журнала: 2024, Номер 1832, С. 148853 - 148853

Опубликована: Март 6, 2024

Язык: Английский

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Functional brain network dynamics mediate the relationship between female reproductive aging and interpersonal adversity

Nature Mental Health, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Abstract Premature reproductive aging is linked to heightened stress sensitivity and psychological maladjustment across the life course. However, brain dynamics underlying this relationship are poorly understood. Here, address issue, we analyzed multimodal data from female participants in Adolescent Brain Cognitive Development (longitudinal, N = 441; aged 9–12 years) Human Connectome-Aging (cross-sectional, 130; 36–60 studies. Age-specific intrinsic functional network mediated link between perceptions of greater interpersonal adversity. The adolescent profile overlapped areas glutamatergic dopaminergic receptor density, middle-aged was concentrated visual, attentional default mode networks. two profiles showed opposite relationships with patterns neural variability cortical atrophy observed psychosis versus major depressive disorder. Our findings underscore divergent maturation senescence, which may explain developmentally specific vulnerabilities distinct disorders.

Язык: Английский

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Linking Oestradiol (E2) Timing and Tempo, Brain Development, and Mental Health in Adolescent Females

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

ABSTRACT Background Earlier timing and faster tempo of puberty have been associated with altered brain development increased mental health symptoms in adolescents, particularly females. However, the role oestradiol (E2) these associations is unclear. Methods Using longitudinal data from US-based Adolescent Brain Cognitive Development SM Study (ABCD ®) , we investigated whether, females (N ∼ 3k), E2 (at age 10) (rate change 10 to 12) were prospectively at 13 via structural 12. Linear mixed-effects models Bayesian mediation fitted investigate aims study. Results Findings showed that was not symptoms. earlier a greater reduction total cortical volume, surface area, area superior middle temporal cortex over time. Further, an increase symptoms, this association mediated by volume Conclusion suggest contribute accelerated gray matter structure adolescent females, for tempo, such changes may partly risk.

Язык: Английский

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The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review

Biological Psychiatry, Год журнала: 2024, Номер 96(7), С. 585 - 603

Опубликована: Июнь 24, 2024

Язык: Английский

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Registered Reports in Child Development: Introduction to the Special Section

Child Development, Год журнала: 2023, Номер 94(5), С. 1093 - 1101

Опубликована: Авг. 21, 2023

Registered Reports (RRs) are an emerging format for publishing empirical journal articles in which the decision to publish article is based on sound conceptualization, methods, and planned analyses rather than specific nature of results. This introduces Special Section Child Development by describing what RRs why they necessary, outlining thought process that guided Section, key thematic insights across eight included collection, providing recommendations developmental researchers interested via RR format. also serves as a formal announcement will be standard option at Development, effective immediately.

Язык: Английский

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The role of pubertal development in the association between trauma and internalising symptoms in female youth

Опубликована: Янв. 15, 2024

ObjectiveExposure to trauma in childhood is associated with an increased risk for internalising symptoms. Alterations pubertal development has been proposed as a potential mechanism underpinning this association. However, longitudinal studies, which are needed examine over time, scarce. The goal of pre-registered study was how exposure shapes the timing and tempo development, turn contributes symptoms female youth. MethodsUsing largest sample date, we characterised profiles across four timepoints youth from Adolescent Brain Cognitive Development (ABCD) Study (N = 4,225, age range 9 14 years) using latent class growth analysis. Pubertal assessed Scale (at timepoints). Trauma quantified post-traumatic stress disorder subscale parent-report Kiddie Schedule Affective Disorders Schizophrenia DSM-5 baseline), were self-report Brief Problem Monitor 3-year follow-up). ResultsPubertal could be grouped into three classes: early starters (9% sample), typical developers (76%), slow (15%). demonstrated higher levels compared developers, while showed least trauma. Youth greater at ages 12–14 years, association mediated by status 9–10 but not faster tempo. Conclusion Accelerated earlier onset transition late adolescence, may through increases

Язык: Английский

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Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Июнь 5, 2024

Depression and Alzheimer’s disease (AD) are prevalent neuropsychiatric disorders with intriguing epidemiological overlaps. Their interrelation has recently garnered widespread attention. Empirical evidence indicates that depressive significantly contribute to AD risk, approximately a quarter of patients have comorbid major disorder, which underscores the bidirectional link between depression. A growing body substantiates pervasive sex differences in both depression: conditions exhibit higher incidence among women than men. However, available literature on this topic is somewhat fragmented, no comprehensive review delineates disparities depression–AD correlation. In review, we bridge these gaps by summarizing recent progress understanding sex-based mechanisms, genetics, therapeutic prospects for depression AD. Additionally, outline key challenges field, holding potential improving treatment precision efficacy tailored male female patients’ distinct needs.

Язык: Английский

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