bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 10, 2023
Abstract
Coarse
measures
of
socioeconomic
status,
such
as
parental
income
or
education,
have
been
linked
to
differences
in
white
matter
development.
However,
these
do
not
provide
insight
into
specific
aspects
an
individual’s
environment
and
how
they
relate
brain
On
the
other
hand,
educational
intervention
studies
shown
that
changes
context
can
drive
measurable
their
matter.
These
studies,
however,
rarely
consider
factors
results.
In
present
study,
we
examined
unique
effect
opportunity
on
development,
even
when
controlling
known
factors.
To
explore
this
question,
leveraged
rich
demographic
neuroimaging
data
available
ABCD
well
data-crosswalk
between
Stanford
Education
Data
Archive
(SEDA).
We
find
is
related
accelerated
accounting
for
factors,
relationship
most
pronounced
tracts
associated
with
academic
skills.
results
suggest
school
a
child
attends
has
impact
development
years
come.
Developmental Cognitive Neuroscience,
Год журнала:
2024,
Номер
67, С. 101386 - 101386
Опубликована: Апрель 22, 2024
Coarse
measures
of
socioeconomic
status,
such
as
parental
income
or
education,
have
been
linked
to
differences
in
white
matter
development.
However,
these
do
not
provide
insight
into
specific
aspects
an
individual's
environment
and
how
they
relate
brain
On
the
other
hand,
educational
intervention
studies
shown
that
changes
context
can
drive
measurable
their
matter.
These
studies,
however,
rarely
consider
factors
results.
In
present
study,
we
examined
unique
relationship
between
opportunity
development,
when
controlling
known
factors.
To
explore
this
question,
leveraged
rich
demographic
neuroimaging
data
available
ABCD
well
data-crosswalk
Stanford
Education
Data
Archive
(SEDA).
We
find
is
related
accelerated
even
accounting
for
factors,
most
pronounced
tracts
associated
with
academic
skills.
results
suggest
school
a
child
attends
has
development
years
come.
Developmental Cognitive Neuroscience,
Год журнала:
2025,
Номер
unknown, С. 101526 - 101526
Опубликована: Фев. 1, 2025
Research
in
developmental
psychology
suggests
that
self-concept
formation
and
mentalizing
capacities,
along
with
their
neural
foundations,
show
significant
change
during
adolescence.
Perspective-taking
tendencies
are
also
believed
to
increase
adolescence,
supporting
the
refinement
of
prosocial
behavior
demands
increasingly
complex
social
relationships.
To
explore
development
of,
relationship
between,
these
processes
early
adolescent
girls
(N
=
172)
completed
a
measure
perspective-taking
self-evaluation
fMRI
task
at
two
waves,
approximately
18
months
apart
(mean
ages
11.62
13.20,
respectively).
In
line
our
hypothesis,
were
positively
associated
age.
Greater
more
prosocial,
less
antisocial,
self-concept.
addition,
dmPFC
activity
increased
age,
but
this
did
not
survive
correction
for
multiple
comparisons
across
all
regions.
Post
hoc
analyses
showed
an
waves
was
significantly
parts
precuneus
wave
2.
Finally,
while
we
observe
cross-variable
coupling,
Bivariate
Latent
Change
Score
model
lower
1
greater
latent
variable
(and
same
true
mean
brain
regions).
Biological Psychiatry Global Open Science,
Год журнала:
2024,
Номер
4(4), С. 100323 - 100323
Опубликована: Апрель 26, 2024
During
the
course
of
adulthood
and
aging,
white
matter
(WM)
structure
organization
are
characterized
by
slow
degradation
processes
such
as
demyelination
shrinkage.
An
acceleration
aging
has
been
linked
to
development
a
range
diseases.
Thus,
an
accurate
description
healthy
brain
maturation,
particularly
in
terms
WM
features,
is
fundamental
understanding
aging.
Biology of Sex Differences,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 26, 2024
Abstract
Background
Puberty
depicts
a
period
of
profound
and
multifactorial
changes
ranging
from
social
to
biological
factors.
While
brain
development
in
youths
has
been
studied
mostly
an
age
perspective,
recent
evidence
suggests
that
pubertal
measures
may
be
more
sensitive
study
adolescent
neurodevelopment,
however,
studies
on
timing
relation
are
still
scarce.
Methods
We
investigated
if
pre-
vs.
post-menarche
status
can
classified
using
machine
learning
cortical
subcortical
structural
magnetic
resonance
imaging
(MRI)
data
strictly
age-matched
females
the
Adolescent
Brain
Cognitive
Development
(ABCD)
cohort.
For
comparison
identified
menarche-related
patterns
age-related
we
trained
prediction
model
Philadelphia
Neurodevelopmental
Cohort
applied
it
same
ABCD
data,
yielding
differences
between
predicted
chronological
referred
as
gaps.
tested
sensitivity
both
these
frameworks
maturation,
specifically
at
menarche
puberty
status.
Results
The
achieved
moderate
but
statistically
significant
accuracy
classification
task,
for
each
subject
class
probability
0
(pre-)
1
(post-
menarche).
Comparison
predictions
revealed
shared
distinct
neurodevelopment
captured
by
approaches.
Continuous
probabilities
were
positively
associated
with
gaps,
only
probabilities—not
gaps—were
menarche.
Conclusions
This
demonstrates
use
classify
MRI
while
accounting
neurodevelopment.
Given
its
towards
timing,
our
work
developed
toward
objective
brain-based
marker
development.
Developmental Cognitive Neuroscience,
Год журнала:
2025,
Номер
72, С. 101518 - 101518
Опубликована: Фев. 8, 2025
The
Adolescent
Brain
Cognitive
Development®
(ABCD)
Study
provides
a
unique
opportunity
to
investigate
developmental
processes
in
large,
diverse
cohort
of
youths,
aged
approximately
9-10
at
baseline
and
assessed
annually
for
10
years.
Given
the
size
complexity
ABCD
Study,
researchers
analyzing
its
data
will
encounter
myriad
methodological
analytical
considerations.
This
review
an
examination
key
concepts
techniques
related
longitudinal
analyses
data,
including:
(1)
characterization
factors
associated
with
variation
trajectories;
(2)
assessment
how
level
timing
exposures
may
impact
subsequent
development;
(3)
quantification
domains
be
outcomes,
including
mediation
models
reciprocal
relationships.
We
emphasize
importance
selecting
appropriate
statistical
address
these
research
questions.
By
presenting
advantages
potential
challenges
this
seeks
equip
foundational
knowledge
tools
make
informed
decisions
as
they
navigate
effectively
analyze
interpret
multi-dimensional
currently
available.
Developmental Psychobiology,
Год журнала:
2025,
Номер
67(2)
Опубликована: Март 1, 2025
ABSTRACT
Pubertal
development
is
theorized
to
shape
the
brain's
response
socio‐emotional
information
in
environment.
Large‐scale
longitudinal
studies,
such
as
Adolescent
Brain
Cognitive
Development
(ABCD)
study,
provide
opportunity
examine
association
between
pubertal
maturation
and
within‐person
changes
neural
activation
emotional
stimuli
over
time.
Leveraging
ABCD
data
(
n
=
9648),
current
study
examines
coupling
parent‐reported
youth's
brain
faces
an
‐back
task
(during
functional
magnetic
resonance
imaging)
across
two
timepoints
(2
years
apart).
Bivariate
latent
change
score
models
were
fit
regions
of
interest
canonically
involved
face
processing
(fusiform),
emotional/motivational
salience
(amygdala,
nucleus
accumbens,
orbitofrontal
cortex
[OFC]),
social
cognition
(temporoparietal
junction
[TPJ])
determine
associations
baseline
status
response,
rate
either
variable
Results
point
both
concurrent
TPJ,
OFC)
but
not
basic
facial
(fusiform).
These
findings
highlight
a
potential
mechanism
for
during
transition
from
childhood
adolescence.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 23, 2025
ABSTRACT
Background
Earlier
timing
and
faster
tempo
of
puberty
have
been
associated
with
altered
brain
development
increased
mental
health
symptoms
in
adolescents,
particularly
females.
However,
the
role
oestradiol
(E2)
these
associations
is
unclear.
Methods
Using
longitudinal
data
from
US-based
Adolescent
Brain
Cognitive
Development
SM
Study
(ABCD
®)
,
we
investigated
whether,
females
(N
∼
3k),
E2
(at
age
10)
(rate
change
10
to
12)
were
prospectively
at
13
via
structural
12.
Linear
mixed-effects
models
Bayesian
mediation
fitted
investigate
aims
study.
Results
Findings
showed
that
was
not
symptoms.
earlier
a
greater
reduction
total
cortical
volume,
surface
area,
area
superior
middle
temporal
cortex
over
time.
Further,
an
increase
symptoms,
this
association
mediated
by
volume
Conclusion
suggest
contribute
accelerated
gray
matter
structure
adolescent
females,
for
tempo,
such
changes
may
partly
risk.
Brain and Behavior,
Год журнала:
2025,
Номер
15(6)
Опубликована: Май 30, 2025
ABSTRACT
Background
Psychotic‐like
experiences
(PLE)
represent
a
risk
factor
for
later
psychotic
disorders
and
marker
general
mental
distress.
The
connectivity
microstructure
of
key
brain
white
matter
pathways,
including
fronto–temporal
trajectories,
have
been
implicated
in
psychosis
psychosis‐risk.
Although
sex
differences
PLE
prevalence
characteristics
reported,
most
neuroimaging
studies
primarily
included
mixed‐sex,
samples
little
research
has
carried
out
females
only.
This
study
examines
the
associations
between
young
to
middle‐aged
females.
Methods
We
analyzed
cross‐sectional
diffusion
magnetic
resonance
imaging
(dMRI)
self‐reported
data
from
661
aged
9–44
years
using
15‐item
version
Community
Assessment
Psychic
Experiences
(CAPE)
questionnaire.
Associations
CAPE
subscales
other
psychopathology
measures
were
tested.
Using
linked
independent
component
analysis
(LICA),
we
decomposed
voxel‐wise
24
dMRI
metrics
across
five
different
models
into
10
spatially
components.
then
examined
association
LICA
subject
weights
age.
Next,
tested
both
total
scores
Bayesian
statistics.
Results
broadly
associated
with
various
domains
psychosocial
factors.
Moderate
evidence
emerged
an
reflecting
broad
complex
pattern
diffusivity
major
inferior
fronto–
occipital
fasciculus,
anterior
thalamic
radiation,
forceps
minor.
persecutory
ideations
subscale
showed
strongest
effect.
Conclusion
are
distinct
multimodal
microstructural
commissural,
association,
thalamocortical
pathways
findings
support
that
is
valuable
tool
fusing
decomposing
advanced
delineate
patterns
show
sensitivity
