Genetics,
Год журнала:
2017,
Номер
208(2), С. 605 - 622
Опубликована: Ноя. 30, 2017
Ecdysteroids
are
steroid
hormones
that
control
many
aspects
of
development
and
physiology.
During
larval
development,
ecdysone
is
synthesized
in
an
endocrine
organ
called
the
prothoracic
gland
through
a
series
ecdysteroidogenic
enzymes
encoded
by
Halloween
genes.
The
expression
genes
highly
restricted
dynamic,
indicating
their
spatiotemporal
regulation
mediated
tight
transcriptional
control.
In
this
study,
we
report
three
zinc
finger-associated
domain
(ZAD)-C2H2
finger
transcription
factors-Séance
(Séan),
Ouija
board
(Ouib),
Molting
defective
(Mld)-cooperatively
biosynthesis
fruit
fly
Drosophila
melanogaster
Séan
Ouib
act
cooperation
with
Mld
to
positively
regulate
neverland
spookier,
respectively,
two
Remarkably,
loss-of-function
mutations
séan,
ouib,
or
mld
can
be
rescued
neverland,
both,
respectively.
These
results
suggest
factors
have
distinct
roles
coordinating
just
Given
spookier
located
constitutive
heterochromatin,
Séan,
Ouib,
represent
first
example
factor
subset
regulates
heterochromatin.
Current Biology,
Год журнала:
2022,
Номер
32(7), С. 1548 - 1562.e6
Опубликована: Март 3, 2022
Nutrition
is
one
of
the
most
important
influences
on
growth
and
timing
maturational
transitions
including
mammalian
puberty
insect
metamorphosis.
Childhood
obesity
associated
with
precocious
puberty,
but
assessment
mechanism
that
links
body
fat
to
early
maturation
unknown.
During
development,
intake
nutrients
promotes
signaling
through
insulin-like
systems
govern
cells
tissues
also
regulates
timely
production
steroid
hormones
initiate
juvenile-adult
transition.
We
show
here
dietary
lipid
cholesterol,
which
required
as
a
component
cell
membranes
substrate
for
biosynthesis,
governs
in
Drosophila
via
promoting
expression
release
peptides.
This
nutritional
input
acts
nutrient
sensor
TOR,
regulated
by
Niemann-Pick-type-C
1
(Npc1)
cholesterol
transporter,
glia
blood-brain
barrier
adipose
tissue
remotely
drive
systemic
insulin
growth.
Furthermore,
increasing
intracellular
levels
steroid-producing
prothoracic
gland
strongly
endoreduplication,
leading
an
accelerated
attainment
checkpoint
normally
ensures
animals
do
not
prematurely.
These
findings,
therefore,
Npc1-TOR
system
couples
sensing
cellular
control
timing,
may
help
explain
both
link
between
cancer
well
connection
(obesity)
puberty.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Май 14, 2024
Abstract
Vesicular
transport
is
essential
for
delivering
cargo
to
intracellular
destinations.
Evi5
a
Rab11-GTPase-activating
protein
involved
in
endosome
recycling.
In
humans,
high-risk
locus
multiple
sclerosis,
debilitating
disease
that
also
presents
with
excess
iron
the
CNS.
insects,
prothoracic
gland
(PG)
requires
entry
of
extracellular
synthesize
steroidogenic
enzyme
cofactors.
The
mechanism
peripheral
uptake
insect
cells
remains
controversial.
We
show
Evi5-depletion
Drosophila
PG
affected
vesicle
morphology
and
density,
blocked
recycling
impaired
trafficking
transferrin-1,
thus
disrupting
heme
synthesis
due
reduced
cellular
concentrations.
ferritin
delivers
as
well,
interacts
physically
Evi5.
Further,
ferritin-injection
rescued
developmental
delays
associated
Evi5-depletion.
To
summarize,
our
findings
critical
via
transferrin-1
ferritin,
implicate
altered
homeostasis
etiology
sclerosis.
Genetics,
Год журнала:
2017,
Номер
208(2), С. 605 - 622
Опубликована: Ноя. 30, 2017
Ecdysteroids
are
steroid
hormones
that
control
many
aspects
of
development
and
physiology.
During
larval
development,
ecdysone
is
synthesized
in
an
endocrine
organ
called
the
prothoracic
gland
through
a
series
ecdysteroidogenic
enzymes
encoded
by
Halloween
genes.
The
expression
genes
highly
restricted
dynamic,
indicating
their
spatiotemporal
regulation
mediated
tight
transcriptional
control.
In
this
study,
we
report
three
zinc
finger-associated
domain
(ZAD)-C2H2
finger
transcription
factors-Séance
(Séan),
Ouija
board
(Ouib),
Molting
defective
(Mld)-cooperatively
biosynthesis
fruit
fly
Drosophila
melanogaster
Séan
Ouib
act
cooperation
with
Mld
to
positively
regulate
neverland
spookier,
respectively,
two
Remarkably,
loss-of-function
mutations
séan,
ouib,
or
mld
can
be
rescued
neverland,
both,
respectively.
These
results
suggest
factors
have
distinct
roles
coordinating
just
Given
spookier
located
constitutive
heterochromatin,
Séan,
Ouib,
represent
first
example
factor
subset
regulates
heterochromatin.
