Molecular mechanisms and consequences of mitochondrial permeability transition

Nature Reviews Molecular Cell Biology, Год журнала: 2021, Номер 23(4), С. 266 - 285

Опубликована: Дек. 8, 2021

Язык: Английский

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The landscape of aging

Science China Life Sciences, Год журнала: 2022, Номер 65(12), С. 2354 - 2454

Опубликована: Сен. 2, 2022

Язык: Английский

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Macrophage Related Chronic Inflammation in Non-Healing Wounds

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Июнь 16, 2021

Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction considered as major contributor thereof. In this review, we describe the origin heterogeneity macrophages during wound healing, compare function in healing non-healing wounds. We consider extrinsic intrinsic factors driving dysregulation, review systemic topical therapeutic approaches for restoration response. Multidimensional analysis highlighted through integration various high-throughput technologies, used to assess diversity activation states well cellular communication wound. This research fills gaps current literature provides promising interventions

Язык: Английский

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Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I

Nature, Год журнала: 2022, Номер 607(7920), С. 756 - 761

Опубликована: Июль 20, 2022

Oocytes form before birth and remain viable for several decades fertilization

Язык: Английский

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Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution

Cell Metabolism, Год журнала: 2024, Номер 36(1), С. 209 - 221.e6

Опубликована: Янв. 1, 2024

Язык: Английский

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A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 8, 2024

Neutrophils are the most abundant innate immune cells. Multiple mechanisms allow them to engage a wide range of metabolic pathways for biosynthesis and bioenergetics mediating biological processes such as development in bone marrow antimicrobial activity ROS production NET formation, inflammation tissue repair. We first discuss recent work on neutrophil functions regulate granulopoiesis, migration trafficking well effector functions. then syndromes with impaired that influenced by genetic environmental factors nutrient availability usage. Here, we particularly focus role specific macronutrients, glucose, fatty acids, protein, micronutrients vitamin B3, regulating biology how this regulation impacts host health. A special section review primarily discusses ways deficiencies could impact increase infection susceptibility. emphasize biochemical approaches explore metabolism relation Lastly, opportunities challenges neutrophil-centered therapeutic immune-driven diseases highlight unanswered questions guide future discoveries.

Язык: Английский

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Mitochondrial heterogeneity and adaptations to cellular needs

Nature Cell Biology, Год журнала: 2024, Номер 26(5), С. 674 - 686

Опубликована: Май 1, 2024

Язык: Английский

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IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs

Nature Immunology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Язык: Английский

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Stem cell quiescence: the challenging path to activation

Development, Год журнала: 2021, Номер 148(3)

Опубликована: Фев. 1, 2021

Quiescence is a cellular state in which cell remains out of the cycle but retains capacity to divide. The unique ability adult stem cells maintain quiescence crucial for life-long tissue homeostasis and regenerative capacity. has long been viewed as an inactive recent studies have shown that it fact actively regulated process are highly reactive extrinsic stimuli. This fuelled hopes boosting reactivation potential improve function during ageing. In this Review, we provide perspective quiescent discuss how transition into cycle. We also current challenges field, highlighting technical advances could help overcome some these challenges.

Язык: Английский

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Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function

Cell stem cell, Год журнала: 2021, Номер 29(1), С. 149 - 159.e7

Опубликована: Окт. 22, 2021

Язык: Английский

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