International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 4101 - 4101
Опубликована: Апрель 7, 2024
Skin
aging
is
a
complex
process
involving
structural
and
functional
changes
characterized
by
decrease
in
collagen
content,
reduced
skin
thickness,
dryness,
the
formation
of
wrinkles.
This
underpinned
multiple
mechanisms
including
free
radical
theory,
inflammation
photoaging
metabolic
theory.
The
immune
system,
an
indispensable
part
body’s
defense
mechanism,
comprises
macrophages,
lymphocytes,
dendritic
cells,
mast
cells.
These
cells
play
pivotal
role
maintaining
homeostasis
responding
to
injury
or
infection.
As
age
advances,
along
with
various
internal
external
environmental
stimuli,
may
undergo
senescence
accelerated
aging,
cell
division
capability,
increased
mortality,
gene
expression
patterns
signaling
pathways,
altered
functions.
collectively
impact
overall
function
system.
review
summarizes
relationship
between
immunity
explores
characteristics
composition
effects
these
on
aging.
Immune
dysfunction
plays
significant
suggesting
that
immunoregulation
become
one
important
strategies
for
prevention
treatment
Molecular Therapy,
Год журнала:
2022,
Номер
30(9), С. 2891 - 2908
Опубликована: Авг. 2, 2022
It
is
well
established
that
macrophages
are
key
regulators
of
wound
healing,
displaying
impressive
plasticity
and
an
evolving
phenotype,
from
aggressive
pro-inflammatory
or
"M1"
phenotype
to
a
pro-healing
"M2"
depending
on
the
healing
stage,
ensure
proper
healing.
Because
dysregulated
macrophage
responses
have
been
linked
impaired
diabetic
wounds,
being
considered
as
therapeutic
target
for
improved
In
this
review,
we
first
discuss
role
in
normal
skin
process
aberrations
occur
under
conditions.
Next
provide
overview
recent
macrophage-based
approaches,
including
delivery
ex-vivo-activated
pharmacological
strategies
aimed
at
eliminating
re-educating
local
macrophages.
particular,
focus
silence
regulator
genes
repolarize
M2
discussion
their
potential
future
clinical
translation.
Advanced Functional Materials,
Год журнала:
2021,
Номер
32(12)
Опубликована: Дек. 5, 2021
Abstract
Macrophage
immunotherapy
is
an
emerging
treatment
strategy
that
modulates
the
immune
system
to
promote
wound
healing.
The
functionality
and
regeneration
of
tissue
depend
on
spatially
temporally
regulating
biophysical
biochemical
microenvironmental
with
poorly
understood
mechanisms.
Biomaterials
are
carefully
crafted
display
deliver
macrophage
regulatory
signals
in
a
precise
near‐physiological
way,
serving
as
powerful
artificial
microenvironments
which
explore
direct
fate
macrophages.
review
starts
discussing
classification
function
macrophages,
then
introduces
polarization
macrophages
different
conventional
wounds
chronic
wounds.
Recent
advances
biomaterials
balance
phenotypes
healing
emphasized.
Finally,
looking
ahead,
potential
ability
biomaterial
scaffolds
modulate
signaling
produce
environment
conducive
discussed.
Advanced Functional Materials,
Год журнала:
2022,
Номер
32(51)
Опубликована: Окт. 9, 2022
Abstract
With
an
increasingly
aging
society,
bone
defects
and
fractures
have
become
significant
threats
to
human
health
quality
of
life.
Currently,
autologous
allogeneic
grafts
remain
the
“gold
standard”
for
clinical
treatment
repair.
However,
transplantation
is
still
clinically
insufficient,
owing
its
substantial
limitations,
such
as
graft
rejection,
donor
functional
defects,
risk
infection.
Therefore,
a
variety
biomaterials
been
developed
facilitate
advancement
tissue
engineering,
focus
research
has
transitioned
from
bioinert
bioactive
biomaterials.
many
not
achieved
satisfactory
therapeutic
effects.
In
recent
years,
advancements
in
osteoimmunology
revealed
that
immune
system,
which
macrophages
are
critical
components,
plays
essential
regulatory
role
regeneration.
this
review,
healing
explored
developments
promote
regeneration
by
modulating
macrophage
polarization
improving
osteoimmune
microenvironment
reviewed.
This
review
provides
reference
development
application
repair
immunomodulation
perspective.
Bioactive Materials,
Год журнала:
2023,
Номер
28, С. 273 - 283
Опубликована: Июнь 1, 2023
Diabetes
mellitus
is
a
chronically
inflamed
disease
that
predisposes
to
delayed
fracture
healing.
Macrophages
play
key
role
in
the
process
of
healing
by
undergoing
polarization
into
either
M1
or
M2
subtypes,
which
respectively
exhibit
pro-inflammatory
anti-inflammatory
functions.
Therefore,
modulation
macrophage
subtype
beneficial
for
Exosomes
perform
an
important
improving
osteoimmune
microenvironment
due
their
extremely
low
immunogenicity
and
high
bioactivity.
In
this
study,
we
extracted
M2-exosomes
used
them
intervene
bone
repair
diabetic
fractures.
The
results
showed
significantly
modulate
decreasing
proportion
macrophages,
thereby
accelerating
We
further
confirmed
induced
conversion
macrophages
stimulating
PI3K/AKT
pathway.
Our
study
offers
fresh
perspective
potential
therapeutic
approach
improve
Bioactive Materials,
Год журнала:
2023,
Номер
26, С. 323 - 336
Опубликована: Март 15, 2023
Chronic
diabetic
wounds
remain
a
globally
recognized
clinical
challenge.
They
occur
due
to
high
concentrations
of
reactive
oxygen
species
and
vascular
function
disorders.
A
promising
strategy
for
wound
healing
is
the
delivery
exosomes,
comprising
bioactive
dressings.
Metformin
activates
endothelial
growth
factor
pathway,
thereby
improving
angiogenesis
in
hyperglycemic
states.
However,
multifunctional
hydrogels
loaded
with
drugs
substances
synergistically
promote
repair
has
been
rarely
reported,
mechanism
their
combinatorial
effect
exosome
metformin
remains
unclear.
Here,
we
engineered
dual-loaded
possessing
tissue
adhesive,
antioxidant,
self-healing
electrical
conductivity
properties,
wherein
4-armed
SH-PEG
cross-links
Ag+,
which
minimizes
damage
goods
investigated
promotion
repair.
Multiwalled
carbon
nanotubes
exhibiting
good
were
also
incorporated
into
generate
hydrogen
bonds
thiol
group,
creating
stable
three-dimensional
structure
loading.
The
model
present
study
suggests
that
PEG/Ag/CNT-M
+
E
hydrogel
promotes
by
triggering
cell
proliferation
relieving
peritraumatic
inflammation
injury.
involves
reducing
level
interfering
mitochondrial
fission,
protecting
F-actin
homeostasis
alleviating
microvascular
dysfunction.
Hence,
propose
drug-bioactive
substance
combination
therapy
provide
potential
developing
function-associated
strategies
treating
chronic
wounds.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(28), С. 31737 - 31750
Опубликована: Июль 8, 2022
Chronic
wounds
cannot
proceed
through
the
normal,
orderly,
and
timely
sequence
of
repair.
The
adverse
cycle
between
excess
reactive
oxide
species
(ROS)
a
persistent
inflammatory
response
is
an
important
mechanism
impaired
wound
healing.
Herein,
by
combining
intrinsic
bioactivities
natural
polysaccharides
drugs,
glycosaminoglycan-based
hydrogel
delivery
system
proposed
to
regulate
microenvironment.
Dynamic
supramolecular
cross-linking
enables
easily
encapsulate
drug
fully
fill
area.
As
backbone
hydrogel,
heparin
captures
chemokines
at
site,
while
hyaluronic
acid
mimics
function
ECM.
hydrophobic
curcumin
has
been
ingeniously
encapsulated
in
micellization,
thereby
exerting
good
ROS
scavenging
ability
anti-inflammatory
activity.
Evaluations
diabetic
mice
showed
that
this
antioxidant
was
effective
reducing
influx
immune
cells
site
down-regulating
response.
Accelerated
healing
also
observed,
as
evidenced
faster
re-epithelialization
better
ECM
remodeling.
can
microenvironment
from
multiple
aspects
achieve
regression
repair,
which
may
provide
new
therapeutic
strategy
for
chronic
wounds.
Bioactive Materials,
Год журнала:
2023,
Номер
28, С. 243 - 254
Опубликована: Май 31, 2023
Diabetic
wound
is
a
great
threat
to
patient's
health
and
lives.
The
refractory
diabetic
shows
spatial
inflammation
patterns,
in
which
the
early-wound
pattern
depicts
deprived
acute
inflammatory
response,
long-term
non-healing
delineates
an
excessive
persistent
due
delayed
immune
cell
infiltration
positive
feedback
loop.
In
this
work,
we
give
points
some
strategies
normalize
dysregulated
process
based
on
differences
healing.
First
of
all,
inhibiting
response
avoid
subsequent
for
early
proposed.
However,
wounds
are
unperceptive
trauma
that
makes
patients
miss
best
treatment
time.
Therefore,
also
introduce
two
wound.
One
strategy
about
changing
chronic
ones,
aims
rejuvenate
M1
macrophages
make
spontaneous
M2
polarization
possible.
To
activate
controllable
proinflammatory
western
medicine
delivers
molecules
while
traditional
Chinese
develops
"wound-pus
promoting
granulation
tissue
growth
theory".
Another
solve
seeking
switches
target
M1/M2
transition
directly.
These
investigations
draw
map
enhancing
healing
from
perspective
patterns
systematically.
RSC Advances,
Год журнала:
2023,
Номер
13(31), С. 21345 - 21364
Опубликована: Янв. 1, 2023
Nanoparticle-modified
hydrogels
exhibit
substantial
promise
in
the
realm
of
wound
healing,
with
their
ability
to
expedite
tissue
regeneration,
mitigate
infection
risks,
and
facilitate
enhanced
therapeutic
outcomes.
Abstract
The
inflammatory
response
is
a
key
factor
affecting
tissue
regeneration.
Inspired
by
the
immunomodulatory
role
of
spermidine,
an
injectable
double
network
hydrogel
functionalized
with
spermidine
(DN‐SPD)
developed,
where
first
and
second
networks
are
formed
dynamic
imine
bonds
non‐dynamic
photo‐crosslinked
respectively.
single
before
photo‐crosslinking
exhibits
excellent
injectability
thus
can
be
printed
in
situ
to
form
hydrogels.
DN‐SPD
has
demonstrated
desirable
mechanical
properties
adhesion.
More
importantly,
“operando”
comparison
hydrogels
loaded
or
diethylenetriamine
(DETA),
sham
molecule
resembling
shown
similar
physical
properties,
but
quite
different
biological
functions.
Specifically,
outcomes
3
sets
vivo
animal
experiments
demonstrate
that
not
only
reduce
inflammation
caused
implanted
exogenous
biomaterials
reactive
oxygen
species
also
promote
polarization
macrophages
toward
regenerative
M2
phenotype,
DN‐DETA
hydrogel.
Moreover,
immunoregulation
translate
into
faster
more
natural
healing
both
acute
wounds
diabetic
wounds.
Hence,
local
administration
affords
simple
elegant
approach
attenuate
foreign
body
reactions
induced
treat
chronic
refractory
