Biosensors,
Год журнала:
2024,
Номер
14(10), С. 473 - 473
Опубликована: Окт. 2, 2024
Urine
analysis
represents
a
crucial
diagnostic
technique
employed
in
clinical
laboratories.
Creatinine
and
uric
acid
urine
are
essential
biomarkers
the
human
body
widely
utilized
analysis.
Research
has
demonstrated
correlation
between
normal
physiological
concentrations
of
creatinine
an
increased
risk
hypertension,
cardiovascular
diseases,
kidney
disease.
Furthermore,
pH
indicates
body’s
metabolic
processes
homeostatic
balance.
In
this
study,
integrated
multi-channel
electrochemical
sensing
system
was
developed,
combining
techniques,
microelectronic
design,
nanomaterials.
The
architecture
intelligent
medical
detection
production
interactive
interface
for
smartphones
were
accomplished.
Initially,
selective
electrodes
designed
creatinine,
acid,
detection.
range
10
nM
to
100
μM
500
4
9
pH.
interference
experiments
also
conducted
verify
specificity
sensors.
Subsequently,
double-sided
function-integrated
hardware
designed,
with
standard
equations
target
analytes
stored
system’s
read-only
memory.
Moreover,
WeChat
mini-program
platform
developed
smartphone
interaction,
enabling
off-body
real-time
display
through
smartphones.
Finally,
aforementioned
smart
wirelessly
interfaced
smartphones,
allowing
primary
healthcare
individual
household
settings.
Micromachines,
Год журнала:
2023,
Номер
14(9), С. 1746 - 1746
Опубликована: Сен. 7, 2023
Natural
enzymes
are
used
as
special
reagents
for
the
preparation
of
electrochemical
(bio)sensors
due
to
their
ability
catalyze
processes,
improving
selectivity
detection.
However,
some
drawbacks,
such
denaturation
in
harsh
experimental
conditions
and
rapid
de-
gradation,
well
high
cost
difficulties
recycling
them,
restrict
practical
applications.
Nowadays,
use
artificial
enzymes,
mostly
based
on
nanomaterials,
mimicking
functions
natural
products,
has
been
growing.
These
so-called
nanozymes
present
several
advantages
over
enhanced
stability,
low
cost,
easy
production,
activity.
outstanding
features
responsible
widespread
areas
catalysis,
energy,
imaging,
sensing,
or
biomedicine.
materials
can
be
divided
into
two
main
groups:
metal
carbon-based
nanozymes.
The
latter
provides
additional
compared
nanozymes,
i.e.,
stable
tuneable
activity
good
biocompatibility,
enzyme
activities
those
peroxidase,
catalase,
oxidase,
superoxide
dismutase,
nuclease,
phosphatase.
In
this
review
article,
we
have
focused
(bio)sensors.
most
recent
applications
revised
illustrated
with
examples
selected
from
literature
last
four
years
(since
2020).
Chemosensors,
Год журнала:
2024,
Номер
12(12), С. 266 - 266
Опубликована: Дек. 17, 2024
In
this
paper,
the
application
of
NiO
nanosheets
(NiO
NSs)
for
detection
methotrexate
(MTX)
is
described.
The
NSs
were
synthesized
using
a
hydrothermal
method.
electrocatalytic
activity
two
modifiers,
ionic
liquid
(IL)
and
NSs,
was
examined
on
carbon
paste
electrode
(CPE)
in
relation
to
MTX,
utilizing
voltammetry
methods
such
as
cyclic
(CV),
linear
sweep
(LSV),
differential
pulse
(DPV),
chronoamperometry
at
0.1
M
phosphate
buffer
solution
(PBS)
pH
=
7.0.
anodic
peak
currents
MTX
NSs/IL/CPE
approximately
3.5
times
greater
than
those
unmodified
CPE.
Based
DPV
measurements,
electrochemical
sensor
demonstrated
response
concentration
range
(LDR:
0.01
µM
160.0
µM),
with
limit
(LOD:
0.003
µM).
Moreover,
good
stability,
repeatability,
reproducibility,
selectivity,
which
importance
electroanalysis
compounds.
Lastly,
practicality
assessed
by
analyzing
levels
urine
samples
pharmaceutical
formulation,
yielding
satisfactory
recovery
rates
97.1%
103.3%.
