Genes & Diseases,
Год журнала:
2023,
Номер
12(1), С. 101175 - 101175
Опубликована: Ноя. 23, 2023
Exosomes,
extracellular
vesicles
originating
from
endosomes,
were
discovered
in
the
late
1980s
and
their
function
intercellular
communication
has
since
garnered
considerable
interest.
Exosomes
are
lipid
bilayer-coated
that
range
size
30
to
150
nm
appear
as
sacs
under
electron
microscope.
Exosome
secretion
is
crucial
for
cell-to-cell
contact
both
normal
physiology
development
spread
of
tumors.
Furthermore,
cancer
cells
can
secrete
more
exosomes
than
cells.
Scientists
believe
complex
tissue
environment
human
body
an
important
reason
cell
invasion
metastasis.
For
example,
some
particles
containing
regulatory
molecules
secreted
tumor
microenvironment,
including
exosomes.
Then
contents
be
released
by
donor
into
interact
with
recipient
promote
migration
Therefore,
this
review,
we
summarized
biogenesis
exosome,
well
exosome
cargo
related
roles.
More
importantly,
review
introduces
discusses
factors
have
been
reported
affect
tumors
highlights
role
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Апрель 22, 2024
Abstract
Cancer-associated
fibroblasts
(CAFs),
the
main
stromal
component
of
tumor
microenvironment
(TME),
play
multifaceted
roles
in
cancer
progression
through
paracrine
signaling,
exosome
transfer,
and
cell
interactions.
Attractively,
recent
evidence
indicates
that
CAFs
can
modulate
various
forms
regulated
death
(RCD)
adjacent
cells,
thus
involving
proliferation,
therapy
resistance,
immune
exclusion.
Here,
we
present
a
brief
introduction
to
basic
knowledge
RCD,
including
apoptosis,
autophagy,
ferroptosis,
pyroptosis.
In
addition,
further
summarize
different
types
RCD
tumors
are
mediated
by
CAFs,
as
well
effects
these
modes
on
CAFs.
This
review
will
deepen
our
understanding
interactions
between
might
offer
novel
therapeutic
avenues
for
future
treatments.
Cancer-associated
fibroblasts
(CAFs)
are
a
diverse
stromal
cell
population
within
the
tumour
microenvironment,
where
they
play
fundamental
roles
in
cancer
progression
and
patient
prognosis.
Multiple
lines
of
evidence
have
identified
that
CAFs
critically
involved
shaping
structure
function
microenvironment
with
numerous
functions
regulating
behaviours,
such
as
metastasis,
invasion,
epithelial-mesenchymal
transition
(EMT).
can
interact
extensively
cells
by
producing
extracellular
vesicles
(EVs),
multiple
secreted
factors,
metabolites.
Notably,
CAF-derived
EVs
been
critical
mediators
therapy
resistance,
constitute
novel
targets
biomarkers
management.
This
review
aimed
to
summarize
biological
detailed
molecular
mechanisms
mediating
resistance
chemotherapy,
targeted
agents,
radiotherapy,
immunotherapy.
We
also
discussed
therapeutic
potential
clinical
management,
thereby
providing
strategy
for
enhancing
efficacy
improving
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Фев. 23, 2024
Gastrointestinal
(GI)
tumors
are
a
significant
global
health
threat,
with
high
rates
of
morbidity
and
mortality.
Exosomes
contain
various
biologically
active
molecules
like
nucleic
acids,
proteins,
lipids
can
serve
as
messengers
for
intercellular
communication.
They
play
critical
roles
in
the
exchange
information
between
tumor
cells
microenvironment
(TME).
The
TME
consists
mesenchymal
components
extracellular
matrix
(ECM),
fibroblasts
being
most
abundant
cell
type
mesenchyme.
Cancer-associated
(CAFs)
derived
from
normal
stem
that
activated
TME.
CAFs
secrete
exosomes
to
modulate
proliferation,
invasion,
migration,
drug
resistance,
other
biological
processes
tumors.
Additionally,
manipulate
function
behavior
through
direct
cell-cell
interactions.
This
review
provides
summary
crosstalk
GI
exosomes,
along
potential
underlying
mechanisms.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 10, 2024
Resistance
of
cancer
cells
to
anticancer
drugs
remains
a
major
challenge
in
modern
medicine.
Understanding
the
mechanisms
behind
development
chemoresistance
is
key
developing
appropriate
therapies
counteract
it.
Nowadays,
with
advances
technology,
we
are
paying
more
and
attention
role
tumor
microenvironment
(TME)
intercellular
interactions
this
process.
We
also
know
that
important
elements
TME
not
only
themselves
but
other
cell
types,
such
as
mesenchymal
stem
cells,
cancer-associated
fibroblasts,
stromal
macrophages.
can
communicate
each
indirectly
(via
cytokines,
chemokines,
growth
factors,
extracellular
vesicles
[EVs])
directly
gap
junctions,
ligand-receptor
pairs,
adhesion,
tunnel
nanotubes).
This
communication
appears
be
critical
for
chemoresistance.
EVs
seem
particularly
interesting
structures
regard.
Within
these
structures,
lipids,
proteins,
nucleic
acids
transported,
acting
signaling
molecules
interact
numerous
biochemical
pathways,
thereby
contributing
Moreover,
drug
efflux
pumps,
which
responsible
removing
from
transported
via
EVs.
International Journal of Oncology,
Год журнала:
2024,
Номер
65(4)
Опубликована: Авг. 30, 2024
The
use
of
antitumor
drugs
represents
a
reliable
strategy
for
cancer
therapy.
Unfortunately,
drug
resistance
has
become
increasingly
common
and
contributes
to
tumor
metastasis
local
recurrence.
immune
microenvironment
(TME)
consists
cells,
cytokines
immunomodulators,
collectively
they
influence
the
response
treatment.
Epigenetic
changes
including
DNA
methylation
histone
modification,
as
well
increased
exportation
have
been
reported
contribute
development
in
cancers.
In
past
few
years,
majority
studies
on
tumors
only
focused
progression
from
mechanistic
standpoint;
examined
whether
TME
can
also
affect
growth
resistance.
Recently,
emerging
evidence
raised
more
concerns
regarding
role
present
review,
it
was
discussed
how
suppressive
adapts
characterized
by
cooperation
cytokines,
stromal
cells
extracellular
matrix.
Furthermore,
reviewed
these
immunological
or
metabolic
alter
immuno‑surveillance
thus
facilitate
addition,
potential
targets
developing
novel
therapeutic
strategies
improve
individualized
therapy
treatment
were
revealed.
Epigenetics & Chromatin,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 15, 2025
Colorectal
cancer
(CRC)
remains
one
of
the
most
common
causes
cancer-related
mortality
worldwide.
Its
progression
is
influenced
by
complex
interactions
involving
genetic,
epigenetic,
and
environmental
factors.
Non-coding
RNAs
(ncRNAs),
including
microRNAs
(miRNAs),
long
non-coding
(lncRNAs),
circular
(circRNAs),
have
been
identified
as
key
regulators
gene
expression,
affecting
diverse
biological
processes,
notably
programmed
cell
death
(PCD).
This
review
aims
to
explore
relationship
between
ncRNAs
PCD
in
CRC,
focusing
on
how
influence
survival,
proliferation,
treatment
resistance.
A
comprehensive
literature
analysis
was
conducted
examine
recent
findings
role
modulating
various
mechanisms,
apoptosis,
autophagy,
necroptosis,
pyroptosis,
their
impact
CRC
development
therapeutic
response.
were
found
significantly
regulate
pathways,
impacting
tumor
growth,
metastasis,
sensitivity
CRC.
Their
these
pathways
highlights
potential
biomarkers
for
early
detection
targets
innovative
interventions.
Understanding
involvement
regulation
offers
new
insights
into
biology.
The
targeted
modulation
ncRNA-PCD
presents
promising
avenues
personalized
treatment,
which
may
improve
patient
outcomes
enhancing
effectiveness
reducing
