RAD18‐ and BRCA1‐dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir
Genes to Cells,
Год журнала:
2024,
Номер
29(11), С. 935 - 950
Опубликована: Авг. 22, 2024
Ganciclovir
(GCV)
is
a
clinically
important
drug
as
it
used
to
treat
viral
infections.
GCV
incorporated
into
the
DNA
during
replication,
where
interferes
with
subsequent
replication
on
GCV-incorporated
templates.
However,
effects
of
host
genome
and
mechanisms
underlying
cellular
tolerance
remain
unclear.
In
this
study,
we
explored
these
using
collection
mutant
DT40
cells.
We
identified
RAD17
Язык: Английский
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir
DNA repair,
Год журнала:
2024,
Номер
144, С. 103773 - 103773
Опубликована: Окт. 9, 2024
Язык: Английский