International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 3991 - 3991
Опубликована: Апрель 23, 2025
Advances
in
medicinal
chemistry
have
led
to
the
development
of
anticancer
and
anti-infectious
drugs.
However,
many
types
cancer
viral
infections
such
as
hepatitis
B
virus
or
SARS-CoV-2
are
still
treated
ineffectively.
Therefore,
further
effective
selective
lead
compounds
potential
drugs
is
highly
demanded.
In
this
study,
we
synthesized
a
novel
series
piperazine-substituted
pyranopyridines
evaluated
their
antiviral
properties.
Antiproliferative
activity
was
determined
panel
various
tumor
cell
lines
well
non-tumor
hepatic
HepaRG
cells.
Mechanisms
cytotoxicity
were
assessed
by
fluorescent
microscopy
techniques.
Antiviral
analyzed
towards
DNA
RNA
viruses
infectious
culture
systems.
Several
showed
antiproliferative
at
micromolar
submicromolar
concentrations.
involve
induction
apoptosis
not
mediated
via
ERK1/2
pathway
oxidative
stress.
exhibit
against
preventing
formation
virion
particles.
This
study
identification
class
with
wide
range
non-toxic
inhibitor
HBV
production.
Molecules,
Год журнала:
2022,
Номер
27(17), С. 5436 - 5436
Опубликована: Авг. 25, 2022
In
past
decades,
anticancer
research
has
led
to
remarkable
results
despite
many
of
the
approved
drugs
still
being
characterized
by
high
systemic
toxicity
mainly
due
lack
tumor
selectivity
and
present
pharmacokinetic
drawbacks,
including
low
water
solubility,
that
negatively
affect
drug
circulation
time
bioavailability.
The
stability
studies,
performed
in
mild
conditions
during
their
development
or
under
stressing
exposure
temperature,
hydrolytic
medium
light
source,
have
demonstrated
sensitivity
parameters.
For
this
reason,
formation
degradation
products
is
assessed
both
pharmaceutical
formulations
environment
as
hospital
waste.
To
date,
numerous
been
developed
for
achieving
tissue-specific
targeting
reducing
toxic
side
effects,
well
improving
stability.
prodrugs
represents
a
promising
strategy
targeted
cancer
therapy
selectivity,
efficacy
active
compounds.
Recent
studies
show
incorporation
into
vesicular
systems,
such
polymeric
micelles
cyclodextrins,
use
nanocarriers
containing
chemotherapeutics
conjugate
monoclonal
antibodies
can
improve
pharmacokinetics,
cellular
absorption
study,
we
summarize
latest
advances
knowledge
regarding
effective
highly
stable
formulated
entrapped
nanosystems.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 976 - 976
Опубликована: Март 17, 2023
Concurrent
developments
in
anticancer
nanotechnological
treatments
have
been
observed
as
the
burden
of
cancer
increases
every
year.
The
21st
century
has
seen
a
transformation
study
medicine
thanks
to
advancement
field
material
science
and
nanomedicine.
Improved
drug
delivery
systems
with
proven
efficacy
fewer
side
effects
made
possible.
Nanoformulations
varied
functions
are
being
created
using
lipids,
polymers,
inorganic
peptide-based
nanomedicines.
Therefore,
thorough
knowledge
these
intelligent
nanomedicines
is
crucial
for
developing
very
promising
systems.
Polymeric
micelles
often
simple
make
high
solubilization
characteristics;
result,
they
seem
be
alternative
other
nanosystems.
Even
though
recent
studies
provided
an
overview
polymeric
micelles,
here
we
included
discussion
on
“intelligent”
from
We
also
summarized
state-of-the-art
most
micellar
respect
treatments.
Additionally,
gave
significant
attention
clinical
translation
potential
treatment
various
cancers.
Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Янв. 19, 2024
Abstract
Humanity
is
suffering
from
cancer
which
has
become
a
root
cause
of
untimely
deaths
individuals
around
the
globe
in
recent
past.
Nanotheranostics
integrates
therapeutics
and
diagnostics
to
monitor
treatment
response
enhance
drug
efficacy
safety.
We
hereby
propose
discuss
all
imaging
diagnostic
tools,
mechanism
targeting
tumor
cells,
current
nanotheranostic
platforms
available
for
cancer.
This
review
discusses
various
agents
novel
molecular
tools
like
MRI,
CT,
PET,
SPEC,
PAT
used
diagnostics.
Emphasis
given
gold
nanoparticles,
silica,
liposomes,
dendrimers,
metal-based
agents.
also
highlight
limitations
different
field
research
treatment.
Due
complexity
this
area,
multifunctional
hybrid
nanoparticles
functionalized
with
targeted
moieties
or
anti-cancer
drugs
show
best
feature
theranostics
that
enables
them
work
on
carrying
delivering
active
materials
desired
area
requirement
early
detection
diagnosis.
Non-invasive
techniques
have
specificity
receptor
binding
internalization
processes
nanosystems
within
cells.
may
provide
appropriate
medicine
at
dose
patient
time.
Graphical
abstract
Pharmaceutics,
Год журнала:
2022,
Номер
14(8), С. 1700 - 1700
Опубликована: Авг. 15, 2022
In
the
last
decade,
nanomedicine
has
arisen
as
an
emergent
area
of
medicine,
which
studies
nanometric
systems,
namely
polymeric
micelles
(PMs),
that
increase
solubility
and
stability
encapsulated
drugs.
Furthermore,
their
application
in
dermal
drug
delivery
is
also
relevant.
PMs
present
unique
characteristics
because
core-shell
architecture.
They
are
colloidal
dispersions
amphiphilic
compounds,
self-assemble
aqueous
medium,
giving
a
structure-type
core-shell,
with
hydrophobic
core
(that
can
encapsulate
drugs),
hydrophilic
shell,
works
stabilizing
agent.
These
features
offer
adequate
steric
protection
determine
hydrophilicity,
charge,
length,
surface
density
properties.
due
to
small
size,
be
absorbed
by
intestinal
mucosa
drug,
they
transport
bloodstream
until
therapeutic
target.
Moreover,
improve
pharmacokinetic
profile
high
load
capacity,
synthesized
reproducible,
easy,
low-cost
method.
silico
approaches
have
been
explored
physicochemical
properties
PMs.
Based
on
this,
computer-aided
strategy
was
developed
validated
enable
poorly
soluble
drugs
established
critical
parameters
maximize
loading,
formulation
stability,
tumor
exposure.
Poly(2-oxazoline)
(POx)-based
display
unprecedented
loading
concerning
water-insoluble
over
60
incorporated
POx
Among
various
stimuli,
pH
temperature
most
widely
studied
for
enhanced
release
at
site
action.
Researchers
focusing
dual
(pH
temperature)
responsive
controlled
improved
systems
mainly
evaluated
cancer
therapy
certain
malignancies
cause
slight
decrease
extracellular
around
site.
This
review
compilation
updated
applications
PMs,
such
based
Pluronics®,
micelleplexes
Pox-based
several
biomedical
applications.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Сен. 15, 2022
Abstract
Gastrointestinal
cancer
(GIC)
is
a
common
malignant
tumour
of
the
digestive
system
that
seriously
threatens
human
health.
Due
to
unique
organ
structure
gastrointestinal
tract,
endoscopic
and
MRI
diagnoses
GIC
in
clinic
share
problem
low
sensitivity.
The
ineffectiveness
drugs
high
recurrence
rates
surgical
drug
therapies
are
main
factors
impact
curative
effect
patients.
Therefore,
there
an
urgent
need
improve
diagnostic
accuracies
treatment
efficiencies.
Nanotechnology
widely
used
diagnosis
by
virtue
its
size
advantages
extensive
modifiability.
In
clinical
GIC,
surface-enhanced
Raman
scattering
(SERS)
nanoparticles,
electrochemical
nanobiosensors
magnetic
intraoperative
imaging
delivery
systems
other
multifunctional
nanoparticles
have
successfully
improved
GIC.
It
important
further
coordinated
development
nanotechnology
treatment.
Herein,
starting
from
this
review
summarizes
which
nanotechnologies
been
applied
recent
years,
cannot
be
practice.
We
also
point
out
challenges
must
overcome
discuss
how
quickly
safely
combine
latest
developed
laboratory
with
applications.
Finally,
we
hope
can
provide
valuable
reference
information
for
researchers
who
conducting
cross-research
on
nanotechnology.
Graphical
Polymers,
Год журнала:
2022,
Номер
14(22), С. 4839 - 4839
Опубликована: Ноя. 10, 2022
Polymeric
micelles,
nanosized
assemblies
of
amphiphilic
polymers
with
a
core–shell
architecture,
have
been
used
as
carriers
for
various
therapeutic
compounds.
They
gained
attention
due
to
specific
properties
such
their
capacity
solubilize
poorly
water-soluble
drugs,
biocompatibility,
and
the
ability
accumulate
in
tumor
via
enhanced
permeability
retention
(EPR).
Moreover,
additional
functionality
can
be
provided
micelles
by
further
modification.
For
example,
micelle
surface
modification
targeting
ligands
allows
accumulation.
The
introduction
stimuli-sensitive
groups
leads
drug’s
release
response
environment
change.
This
review
highlights
progress
development
multifunctional
polymeric
field
cancer
therapy.
will
also
cover
some
examples
that
are
applied
imaging
theragnosis.
Nutrients,
Год журнала:
2023,
Номер
15(14), С. 3136 - 3136
Опубликована: Июль 13, 2023
Polyphenols
derived
from
fruits,
vegetables,
and
plants
are
bioactive
compounds
potentially
beneficial
to
human
health.
Notably,
such
as
quercetin,
curcumin,
epigallocatechin-3-gallate
(EGCG),
resveratrol
have
been
highlighted
antiproliferative
agents
for
cancer.
Due
their
low
solubility
limited
bioavailability,
some
alternative
nanotechnologies
applied
encapsulate
these
compounds,
aiming
improve
efficacy
against
In
this
comprehensive
review,
we
evaluate
the
main
nanotechnology
approaches
therapeutic
potential
of
polyphenols
cancer
using
in
vitro
studies
vivo
preclinical
models,
highlighting
recent
advancements
field.
It
was
found
that
polymeric
nanomaterials,
lipid-based
inorganic
carbon-based
nanomaterials
most
used
classes
nanocarriers
encapsulating
polyphenols.
These
delivery
systems
exhibit
enhanced
antitumor
activity
pro-apoptotic
effects,
particularly
breast,
lung,
prostate,
cervical,
colorectal
cells,
surpassing
performance
free
compounds.
Preclinical
trials
xenograft
animal
models
revealed
decreased
tumor
growth
after
treatment
with
polyphenol-loaded
systems.
Moreover,
interaction
polyphenol
co-delivery
polyphenol–drug
is
a
promising
approach
increase
anticancer
decrease
chemotherapy
side
effects.
innovative
hold
significant
implications
advancement
clinical
research.
Heliyon,
Год журнала:
2023,
Номер
9(11), С. e21227 - e21227
Опубликована: Окт. 20, 2023
The
past
decade
has
witnessed
a
breakthrough
in
novel
strategies
to
treat
cancer.
One
of
the
most
common
cancer
treatment
modalities
is
chemotherapy
which
involves
administering
anti-cancer
drugs
body.
However,
these
can
lead
undesirable
side
effects
on
healthy
cells.
To
overcome
this
challenge
and
improve
cell
targeting,
many
nanocarriers
have
been
developed
deliver
directly
cancerous
cells
minimize
tissues.
majority
research
studies
conclude
that,
using
encapsulated
much
safer
more
effective
alternative
than
delivering
drug
alone
its
free
form.
This
review
provides
summary
types
mainly
studied
for
delivery,
namely:
liposomes,
polymeric
micelles,
dendrimers,
magnetic
nanoparticles,
mesoporous
gold
carbon
nanotubes
quantum
dots.
In
review,
synthesis,
applications,
advantages,
disadvantages,
previous
nanomaterials
are
discussed
detail.
Furthermore,
future
opportunities
possible
challenges
translating
materials
into
clinical
applications
also
reported.
